ID U3JPS2_FICAL Unreviewed; 546 AA.
AC U3JPS2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Peroxisomal targeting signal 1 receptor {ECO:0000256|ARBA:ARBA00018416};
DE AltName: Full=PTS1-BP {ECO:0000256|ARBA:ARBA00030232};
DE AltName: Full=Peroxin-5 {ECO:0000256|ARBA:ARBA00032505};
GN Name=PEX5 {ECO:0000313|Ensembl:ENSFALP00000004776.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000004776.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000004776.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000004776.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Peroxisome matrix
CC {ECO:0000256|ARBA:ARBA00004253}.
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000256|ARBA:ARBA00005348}.
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DR AlphaFoldDB; U3JPS2; -.
DR STRING; 59894.ENSFALP00000004776; -.
DR Ensembl; ENSFALT00000004800.2; ENSFALP00000004776.2; ENSFALG00000004586.2.
DR eggNOG; KOG1125; Eukaryota.
DR GeneTree; ENSGT00940000156605; -.
DR HOGENOM; CLU_013516_4_0_1; -.
DR Proteomes; UP000016665; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130:SF2; PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR; 1.
DR PANTHER; PTHR10130; PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 275..308
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 395..428
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 429..462
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 546 AA; 61661 MW; 46C3B7F67E62978B CRC64;
MLMFSSGKPF FHTPWLCLFI FCAMFVIHLC IWQLVGEFLQ AQNAPLLSRA PQTFKMDDLL
AEMQEIEQSS FRQAPQRAPG VAALALSENW TQEFLAAADN AGDVSSDYNE ADWSQEFIAE
VTDPLSVSPA KWAEEYLEQS EEKLWLGESE DQSLADKWYE EYQPEDDLKK TVTDFLSKVD
DPKLKNTESD VEFWDKLQAE CEEMAKRDAE AHPWLSEYED LNSSSYDKGY QFEEDNPMRD
HPDAFEEGRK RLEEGDLPNA VLLFEAAVQQ RPDHMEAWQY LGTTQAENEQ ELLAISALRR
CLELQPGNLT ALMALAVSFT NESLQKQACE TLRDWLRHKP DYAHLLNKEP EESVSATSLG
PSKRVLSSLL SDSLFMEVKE LFLAAVRSNP STVDPDVQCG LGVLFNLSGE YEKAVDCFSA
ALSVRPNDHL LWNKLGATLA NGNRSEEAVA AYRRALELQP GYIRSRYNLG ISCINLGAHR
EAVEHFLEAL HMQQKSRGPR GQQGAMSDNI WSTLRMALSM LGQSDLYGAA DARDLPTLLR
AFGLQQ
//
