ID U3JWL3_FICAL Unreviewed; 844 AA.
AC U3JWL3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN Name=LOC101812848 {ECO:0000313|Ensembl:ENSFALP00000007167.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007167.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000007167.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000007167.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_005054760.1; XM_005054703.2.
DR RefSeq; XP_016157791.1; XM_016302305.1.
DR AlphaFoldDB; U3JWL3; -.
DR Ensembl; ENSFALT00000007199.2; ENSFALP00000007167.2; ENSFALG00000006869.2.
DR GeneID; 101812848; -.
DR KEGG; fab:101812848; -.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00950000183101; -.
DR HOGENOM; CLU_017821_1_0_1; -.
DR Proteomes; UP000016665; Chromosome 15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR PANTHER; PTHR24043:SF5; SCAVENGER RECEPTOR CLASS F MEMBER 2; 1.
DR Pfam; PF00053; Laminin_EGF; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00180; EGF_Lam; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 319..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 440..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 136..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 844 AA; 90751 MW; AEEB05F0376846A7 CRC64;
MCTCHPNGQC EDVTGQCTCN ANRWGPKCES ICLCKHGKCD QRTGKCTCEP NWWGPQCSNS
CYCSHNSQCD QQTGNCRCQP GWWGRGCNNQ CSCNNSPCEQ FTGRCQCRER TFGPRCDRYC
QCYRGKCSQV DGTCTCEPGY RGKYCREPCP AGFYGQGCRR RCGQCKSLQP CTVADGRCLT
CEAGWNGTKC DQPCSPGFYG EGCEKLCPPC KDGHTCNHIN GKCSHCNPGW IGDRCETKCR
NGTYGENCAF VCSDCVNGQC HFETGQCLCH PGSHGTYCNL TCPPGRHGAN CAEVCGCHDG
ACDPLTGACH MEANQRMGVI GAGALLALLL ILLLSLLCCC CVYRKKDEAS GSSQEPAAAK
KPPRRLCGRF SRIGMKLPRI PLRRQKLPKV MVAHHDLENT LNCSFIEPLS VVEQPSPSWS
SRGSFSSFDT TDEGPVYCVP HEESMGDSRD RGTPASPGDK LVVPISGEEA GEYTFLKETG
SVRAFPTDSS ETPLLKSSDS ERSSCGSGSA GAALYARVAR LSKQSKEEED ATAEPRSPEK
PPSPERTKPR PPDPATKPKV SWIHGRFSSG QSNSLPAPSQ PPEQVGARSG SPEQEQSLAR
RKRSPSETSA NVQGRAEEKG GSRGKEKAQK QPKEPGIPEG KSSLCGEPQS PSKPKQRSKA
GSEPMETING AVQNAFRKMG AFQPERRAGD TRDAPCSPGT SKPRSEPLYP QLASELAAQL
KEKTQSLNKG DGGIRANGVG AQREKPTPPQ KAKRSAAAGG QKTSKPLLPT SPHLQKLIPA
AAETAAGEPK WVEKPSAGSG QDQTLPTDQT AKKTPIKKPP RKKSREASLE PPRAAAAVPA
QAVQ
//
