ID U3JYH2_FICAL Unreviewed; 953 AA.
AC U3JYH2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Rubicon autophagy regulator {ECO:0000313|Ensembl:ENSFALP00000007826.2};
GN Name=RUBCN {ECO:0000313|Ensembl:ENSFALP00000007826.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007826.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000007826.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000007826.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3JYH2; -.
DR STRING; 59894.ENSFALP00000007826; -.
DR Ensembl; ENSFALT00000007858.2; ENSFALP00000007826.2; ENSFALG00000007498.2.
DR eggNOG; KOG1829; Eukaryota.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000160658; -.
DR HOGENOM; CLU_013778_0_0_1; -.
DR OrthoDB; 126314at2759; -.
DR Proteomes; UP000016665; Chromosome 9.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd17686; RUN_RUBCN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR048569; RUBC_PIKBD.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF21054; RUBC_PIKBD; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 1..129
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 226..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 500..527
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 226..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 105750 MW; B6A960C44E1F21F3 CRC64;
MHSILYHGLI HDKVCCRQKD YWQFVKDIRW LSPGSAHHLE KFISLQESSQ RDPEGPGDQA
LAQLWLQHSL QCHCLSAQLR PLLGNRQYIR KFYADTAFLL SDAHVTAMLQ CLEAVEQNNP
RLLAQIDTSM LAGTSLPSLC VSDPSAGTRE MCDHSGEGHK SRLPGALGCL DHFTESLLTR
KSDNPSPVTK SQSLTALPAS PCVPAAACSQ QRCFGSFSSL QHPASSDRRL MSSCGSSNSS
QPQERCPSTR SSSFSEGRSP LEQPSSVTRF HVPSPKDPFS PASEMSSSTT SQSEDTWTGS
QDDPQSDVND GPEYLAIGNL GRRGRAGSST STSSTKSSSS KLFSSSSSQK LDSVSSLGEQ
GASGGGSRGL SLLRRSSFSE GQSSAPQGIL KKSHMRSHSD TNVTSGKLHE SHGDPGGGRG
PVSASTQSSE LSTPSSLYME YDSGQYLSSG EGMFRRPSEG QSLISYLSEQ DFGSCADLEK
ENAHFSISES LIAAIELMKC NMMSRQLEEE EEDSDKEIQE LKQKIRIRRQ QIRTRHLFPT
CQEMGSDSLM ATDSGSQFSS HGSMRLSDSG SAEDVEEYEI RDADIKRNPD SSRKSFLSSD
SISHSFLNSN SAEAVAMGLL KQFEGMQLPA ASELEWLVPE HDAPQKLLPI PDSLPISPDD
GEHADIYKLR IRVRGNLEWA PPRPQIIFNV HSALTRKVAV AKQNYRCAGC GIRTDPDYIK
RLRYCEYLGK YFCQCCHENA QTVIPSRILR KWDFSKYYVS NFSKDLLSKI WSDPLFNVQA
INPGLYQKVK ALNQVRLLRI QLFHMKNMFK TCRLAKDLLD SFDTVPGHLT EDLHLYSLSD
FSAIKKGDLM PRLTELLKAG SMHVDKCMLC QAKGFICEFC QNEDDIIFPF ELNKCRTCED
CKACYHKSCF KSTPCPRCER LQARRELMDK QSTEPYSSDC EDKLEQPEAV AAT
//
