ID U3JZV8_FICAL Unreviewed; 924 AA.
AC U3JZV8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Diaphanous related formin 3 {ECO:0000313|Ensembl:ENSFALP00000008312.2};
GN Name=DIAPH3 {ECO:0000313|Ensembl:ENSFALP00000008312.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008312.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008312.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008312.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR AlphaFoldDB; U3JZV8; -.
DR STRING; 59894.ENSFALP00000008312; -.
DR Ensembl; ENSFALT00000008346.2; ENSFALP00000008312.2; ENSFALG00000007940.2.
DR eggNOG; KOG1924; Eukaryota.
DR GeneTree; ENSGT00940000157767; -.
DR HOGENOM; CLU_002356_0_0_1; -.
DR Proteomes; UP000016665; Chromosome 1.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF9; PROTEIN DIAPHANOUS HOMOLOG 3; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 1..343
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 462..855
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 878..905
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 381..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..424
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 924 AA; 106349 MW; 6444D41FD577CA65 CRC64;
MNLNEDKKMP LREKDFNTKK EMVMQYISTA SKSGSLKNSR KISPQEFIQD LKSGSTDERL
VTCLESLRVS LTSNPVSWVE NFGREGLGLL LDVLERLVET KNQDRLVKRS QHKVIQCLRA
FMNNKYGLER ILGEERSLLL LAKAIDPKQT NMMTDIVKLL SAMCIVGEEN ILEKILEVVT
AAAEEKNVDR FSPIVEGLQD NSVQLQVACM QLINALVTSP DDLDFRLHIR NEFMRTGLKE
ILPQLQCIKN EALDIQLKVF NEHKEEDMIE FSHRLEDIRS ELEYPFEGWC DLYSFKDTSA
EGYFLSILQH LLLIRNDYFI RPQYFKLIEE CVSQIVLHRN GTDPDFTYRK RLDINFSHLL
EYFPYQYGSV PPGFLPSTHG DASVVPLEGA GPHQFPPPPP PPLPSNGAIP PPPPPPPLPP
PLLNSLGAPL GFGGAPPPPP LPGLPGLQWS PPSCALPFGM KPKKEFKPEV TMKRLNWSKI
RPQEMTESCF WVKAEEEKYE NADMLCKLEL TFCCQKREEE DFEEKKSIKK RIKELKVLDP
KIAQNLSIFL GSFRVPYEEI KMMILEVDET QLSESMIQNL IKHLPEQEQL NALSKFKNEY
NNLSEPEQFG VVMSNVKRLR PRLSAILFKL QFEEQVNSIK PDIMAVSAAC EEIKKSKSFS
KLLELVLLMG NYMNAGSRNA QTFGYNLSSL CKLKDTKSAD QKTTLLHFLV EVCEESYQDV
LNFVEDFQHL DKASKVSAEN LEKSLKHMER QLQQLEKDLK TFPVPEDKHD KFVAKIFLVN
AKEDFQKVSR MHENMEKLYQ NVMGYYAIDL KKVSVEEFLT DLNNFRMMFM QAVKENIRRR
EAEEKQRRAK IAKEKAEKEK LERQQKKKRL LEMKTEGEET GVMDSLLEAL QSGAAFRDRR
RRTPSPTTQR PVLKACNHGN EPYS
//
