ID U3JZX3_FICAL Unreviewed; 634 AA.
AC U3JZX3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Aspartyl-tRNA synthetase 2, mitochondrial {ECO:0000313|Ensembl:ENSFALP00000008327.1};
GN Name=DARS2 {ECO:0000313|Ensembl:ENSFALP00000008327.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008327.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008327.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008327.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Type 1 subfamily. {ECO:0000256|ARBA:ARBA00006303}.
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DR RefSeq; XP_016155898.1; XM_016300412.1.
DR AlphaFoldDB; U3JZX3; -.
DR STRING; 59894.ENSFALP00000008327; -.
DR Ensembl; ENSFALT00000008361.2; ENSFALP00000008327.1; ENSFALG00000007984.2.
DR GeneID; 101806245; -.
DR KEGG; fab:101806245; -.
DR CTD; 55157; -.
DR eggNOG; KOG2411; Eukaryota.
DR GeneTree; ENSGT01030000234618; -.
DR HOGENOM; CLU_014330_3_1_1; -.
DR OMA; YQLDVEM; -.
DR OrthoDB; 1046261at2759; -.
DR Proteomes; UP000016665; Chromosome 8.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004815; F:aspartate-tRNA ligase activity; IEA:Ensembl.
DR GO; GO:0050560; F:aspartate-tRNA(Asn) ligase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0070145; P:mitochondrial asparaginyl-tRNA aminoacylation; IEA:Ensembl.
DR CDD; cd00777; AspRS_core; 1.
DR CDD; cd04317; EcAspRS_like_N; 1.
DR Gene3D; 3.30.1360.30; GAD-like domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00044; Asp_tRNA_synth_type1; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004524; Asp-tRNA-ligase_1.
DR InterPro; IPR047089; Asp-tRNA-ligase_1_N.
DR InterPro; IPR002312; Asp/Asn-tRNA-synth_IIb.
DR InterPro; IPR047090; AspRS_core.
DR InterPro; IPR004115; GAD-like_sf.
DR InterPro; IPR029351; GAD_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR NCBIfam; TIGR00459; aspS_bact; 1.
DR PANTHER; PTHR22594:SF5; ASPARTATE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22594; ASPARTYL/LYSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF02938; GAD; 1.
DR Pfam; PF00152; tRNA-synt_2; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR PRINTS; PR01042; TRNASYNTHASP.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF55261; GAD domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..634
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004646007"
FT DOMAIN 176..594
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 634 AA; 70857 MW; 35D120B7599A8765 CRC64;
MALPRLLLLR ALHRAAAAAA PAAPPAAPAA PDFNSFVTRT NTCGELRSAH VGQKVTLYGW
VQYQRQGLFL VLRDFQGLTQ VIIPQDEAHS QVKELLSSAP VESVVRVTGT VSPRPLGQQN
PKMPTGDIEV KAETAEILNS CKKLPFEIKD FIKKSEALRM QYRYLDLRSA RLQSNLRLRS
RVVMRMRHYL CNLHGFVDVE TPTLFKRTPG GAKEFLVPSR EAGKFYSLPQ SPQQFKQLLM
VGGLDRYFQV ARCYRDEGSR PDRQPEFTQI DIEMSFVDQA GIQRLIEGLL QHSWPEERGS
IRTPFPSMTY EEALAEYGTD KPDTRFGMKI VDISDVLRGS NIHFVQNALS YPHGSVRAIC
IPQGVRYLTN KDLESLKESA KSQFNQEIME IICRPDGSLK SLLTKFLGEK EQSELIQALN
MQEDDVVLLA AGGHKQVCSA LGALRLLSAD LLEAAGLALR DPTAFHFLWV VDFPLFLPKA
ENPTELESAH HPFTAPHPSD ASLLYSDPTK VRSQHYDLVL NGNEVGGGSI RIHSAEQQRF
VLEKVLKEDS EVLSHLIEAL EFGAPPHGGI ALGLDRLISL IVDAPSIRDV IAFPKSFRGR
DLMGNAPDYV TPEELEPYHI QVSWPLEEKE AKKN
//
