ID U3K093_FICAL Unreviewed; 451 AA.
AC U3K093;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Solute carrier family 39 member 8 {ECO:0000313|Ensembl:ENSFALP00000008447.2};
GN Name=SLC39A8 {ECO:0000313|Ensembl:ENSFALP00000008447.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008447.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008447.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008447.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR AlphaFoldDB; U3K093; -.
DR STRING; 59894.ENSFALP00000008447; -.
DR Ensembl; ENSFALT00000008485.2; ENSFALP00000008447.2; ENSFALG00000008104.2.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000158926; -.
DR HOGENOM; CLU_015114_13_0_1; -.
DR Proteomes; UP000016665; Chromosome 4.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0140412; F:zinc:bicarbonate symporter activity; IEA:Ensembl.
DR GO; GO:0006525; P:arginine metabolic process; IEA:Ensembl.
DR GO; GO:0070574; P:cadmium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:1990079; P:cartilage homeostasis; IEA:Ensembl.
DR GO; GO:0098849; P:cellular detoxification of cadmium ion; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:Ensembl.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:Ensembl.
DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0061757; P:leukocyte adhesion to arterial endothelial cell; IEA:Ensembl.
DR GO; GO:0015694; P:mercury ion transport; IEA:Ensembl.
DR GO; GO:1990540; P:mitochondrial manganese ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0097080; P:plasma membrane selenite transport; IEA:Ensembl.
DR GO; GO:0006487; P:protein N-linked glycosylation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IEA:Ensembl.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191:SF2; METAL CATION SYMPORTER ZIP8; 1.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR Pfam; PF02535; Zip; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 48348 MW; 5AAB0E43F8C62B53 CRC64;
PPPPPPPPPP PPPPPPPPPP PPPPPPPPPP PSAGQLSALL QRLGAAPALG SALPLAHLHH
NQCLTSEEIF SLHGIPNDSL VSNSSFSTIC PAVLQQLIFH PCDPQESFAD ASKPHSLQVW
GFGFLAVSII NLASLLGLIL TPLLKKSYFP KVLTYFVGLA IGTLFSNAIF QLIPEAFGFD
PKVDNYVEKA VAVFGGFYIL FFVERVLKVI LKLYNKTDHN YFENGEENHS QDKTDSPKPP
SPSNGGTCYA NSAVIEGNGN LGFDSISVVS AQEEATQSSL CKCLKGRPLS KIGTIAWMVT
LSDAVHNFID GLAIGASFTL SLLQGLSTSI AILCEEFPHE LGDFVILLNA GMSTRQALFF
NFLSACSCYV GLAFGILVGN NFAPNIIFAI AGGMFLYISL ADMFPEMNDM VREKVTGRKT
DLTFFLIQNA GLLTGFTAIL MITLYAGNIE L
//
