GenomeNet

Database: UniProt
Entry: U3K159_FICAL
LinkDB: U3K159_FICAL
Original site: U3K159_FICAL 
ID   U3K159_FICAL            Unreviewed;      1640 AA.
AC   U3K159;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSFALP00000008763};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008763, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000008763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N.,
RA   Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K.,
RA   Qvarnstrom A., Uebbing S., Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula
RT   flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000008763}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000008763}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTO01001611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFALT00000008801; ENSFALP00000008763; ENSFALG00000008409.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000016665; Unplaced.
DR   GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0019227; P:neuronal action potential propagation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     21     48       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    378    402       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    414    435       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    497    525       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    584    610       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    853    871       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    892    911       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    967    995       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1093   1117       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1176   1194       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1206   1224       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1236   1256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1293   1321       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1397   1420       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1     55       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      134    336       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      387    614       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      624    847       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      851   1125       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1175   1430       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       45     83       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1640 AA;  186632 MW;  705149143EFA90DF CRC64;
     MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATMEEAE
     QKEAEFQQML EQLKKQQEAA QSAAVAAAAV TASAESREPS AGGEAGGLSE SSSDASKLSS
     KSAKERRNRR KKRKQKEQSG GEEKDEDEFH KSESEDSIRR KGFRLSIEGN RLTYEKKYSS
     PHQSLLSIRG SLFSPRRNSR TSLFSFRGRA KDVGSENDFA DDEHSTFEDN DSRRDSLFVP
     RRHGERRNSN ISQASRSSRM LAVFPVNGKM HSTVDCNGVV SLVGGPSVPT SPVGQLLPEG
     TTTEPEMRKR ISGSFHVSMD FLEDPALRER AMSIASILTN TVEELEESRQ KCPPCWYKFA
     NIFLIWDCSP HWLKVKHIVN LVVMDPFVDL AITICIVLNT LFMAMEHYPM TDEFNNVLSV
     GNLVFTGIFT AEMFLKIIAM DPYYYFQEGW NIFDGFIVTL SLVELGLADV EGLSVLRSFR
     LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKSYKECVCK
     ISSDCELPRW HMHDFFHSFL IVFRVLCGEW IETMWDCMEV AGQAMCLIVF MLVMVIGNLV
     VLNLFLALLL SSFSADNLAV TDDDNEMNNL QIAVARMQKG IDYVKRKVRE FIQKAFVRKQ
     KVLDEIKPLE DLNNKKQKAL DEIKPLEDLN NKNSCISNHT TVELSKDHDY IKDANGTTSG
     IGTGSSVEKY IIDESDYMSF INNPSLTVTV PIAVGESDFE NLNTEEFSSE SDLEESKEKL
     NSSSSSEGST VDIGLPAEEQ PEAEPEEAQE PEACFTEGCV RRFKCCQVSI EEGRGKQWWN
     LRKTCFRIVE HNWFETFIVF MILLSSGALA FEDIYIEQRK TIKTMLEYAD KVFTYIFILE
     MLLKWVAYGY QTYFTNAWCW LDFLIVDVSL VSLTANALGY SELGAIKSLR TLRALRPLRA
     LSRFEGMRVV VNALLGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFYYC VNTTTDERFE
     VDQINNFSQC EELIKNNQSA RWKNVKVNFD NVGFGYLSLL QVATFKGWMD IMYAAIDSRD
     VLLQPKYEDN LYMYLYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKFGGQ DIFMTEEQKK
     YYNAMKKLGS KKPQKPIPRP GNKFQGMVFD FVTQQVFDIS IMILICLNMV TMMVETDDQS
     EEMENILYWI NLVFIVLFTG ECVLKLISLR HYYFTIGWNI FDFVVVILSI VGMFLAEMIE
     KYFVSPTLFR VIRLARIGRI LRLIKGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYAI
     FGMSNFAYVK REAGIDDMFN FETFGNSMIC LFQITTSAGW DGLLAPILNS GEPDCDPHKD
     HPGSSVKGDC GNPSVGIFFF VSYIIISFLV VVNMYIAVIL ENFSVATEES AEPLSEDDFE
     MFYEVWEKFD PDATQFMEFE KLSDFAAALD PPLHLPKPNK VQLIAMDLPM VSGDRIHCLD
     ILFAFTKRVL GESGEMDALR IQMEDRFMAA NPSKVSYEPI TTTLKRKQEE VSAVIIQRAY
     RRHLLKRTVK QASFIYNKNK TEGGAGQGMK DEILIDKLNE NSFTEKTDIT ASTAVCPPSY
     DRVMRPVKEK HEKEDKDGQK
//
DBGET integrated database retrieval system