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Database: UniProt
Entry: U3K1H7_FICAL
LinkDB: U3K1H7_FICAL
Original site: U3K1H7_FICAL 
ID   U3K1H7_FICAL            Unreviewed;      1108 AA.
AC   U3K1H7;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   SubName: Full=Transient receptor potential cation channel subfamily A member 1 {ECO:0000313|Ensembl:ENSFALP00000008881};
GN   Name=TRPA1 {ECO:0000313|Ensembl:ENSFALP00000008881};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008881, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000008881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N.,
RA   Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K.,
RA   Qvarnstrom A., Uebbing S., Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula
RT   flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000008881}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000008881}.
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DR   EMBL; AGTO01021040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFALT00000008919; ENSFALP00000008881; ENSFALG00000008479.
DR   GeneTree; ENSGT00900000140877; -.
DR   OMA; YYIEYNF; -.
DR   OrthoDB; EOG091G01BG; -.
DR   Proteomes; UP000016665; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0032421; C:stereocilium bundle; IEA:Ensembl.
DR   GO; GO:0015278; F:calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0097604; F:temperature-gated cation channel activity; IEA:Ensembl.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050968; P:detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR   GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR   GO; GO:0042493; P:response to drug; IEA:Ensembl.
DR   GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   GO; GO:0050955; P:thermoception; IEA:Ensembl.
DR   CDD; cd00204; ANK; 5.
DR   Gene3D; 1.25.40.20; -; 6.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR030288; TRPA1/painless.
DR   PANTHER; PTHR24190; PTHR24190; 1.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF12796; Ank_2; 5.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 14.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 9.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    708    730       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    750    768       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    812    832       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    852    874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    918    944       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       49    566       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT       84    116       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      151    183       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      225    257       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      295    327       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      328    360       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      399    431       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      432    464       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      468    493       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      534    566       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   1108 AA;  125242 MW;  DA9B524062ED55CF CRC64;
     SAYQGVVCEA DAASVASQDV FKVISDGSAC RLRSFIKKNR SGLTKVDELN ATPLHHAAEG
     GQIELMQLII DDSSCEALNV MDSSGNTPLH WATKKNQVES VRLLLSRGAN PNILNSNMMA
     PLHMAVQSLH NEIVKILVQH SSTDVNLEGE AGNTPIIVAC YKDNPEALTL LIENGGKICK
     ANKTGCMPIH AAAFSGAKTC LEILLKKGEE LGHSAKTHIN FTNNGKCSPL HLAVQSGDLE
     MIKMCIEFGA QIDLKQNEKC TALHFAATQG ATEIVKLMMS SYAGEESIID AVDGNKETLL
     HRTALFDHYE LAEYLISMGA NIDSVDIEGR SPLLLATSCA SWKIVNLLLS KGANVSLKDH
     LGRNFLHLTV LQPGGLQHLN EKYLQMEHIK NLVVDEDNEG CTPLHYACRQ GVALSVNNLL
     SLNVSIYSKS RDKKSPLHFA ASYGRINTCQ RLIRDMKDTR LLNEGDKKGM TPLHLAAQNG
     HEKVVQFLLK RGALFLCDYK GWTALHHAAF GGYTRTMQII LDTNVKCTDR VDEEGNTALH
     LAAREGHAKA VRLLLDYGAK ILFNKAVASF FHEAIHNRRK DVVSAVILHK RWEEAVVTFS
     HYSTANKCPL LEMVEYLPDS FKLVLDNCII ESSEEKTSRD FYIEYNFRYL QCPLTLNRKL
     KDGEDIFYEP LTTLNAMVRH NRMELLSHPV CKEYLLMKWM AYGFRAHLMN LGIYSLGLIP
     LTLLVTHIQP GRPLNGTELY EDFHSKKDSY FTRVCMCLVL IMSLLGICKE IFQLIQQKLK
     YLLDYSNLLD WTIYTTSIIF VSSLFINTPA HLQWECGAIA VYLSWMNFLL YLQRFENYGI
     YVVMFWEILR TLIRIAVVFF FLILAFGLSF FVLLGSQQQT YSTPLLSVMK TFAMMLGDIN
     YHDAFLDPLL SSELPYPFLS YTVLIIFTLL IPILLMNLLI GLAVGDIAEV QKYAALKRIA
     MQVNLHTNLE KKLPFWFLSR VDQESITVYP NRPRYCGFMS VFQYCFGCED STTYAQSPDT
     TLELEVLKQK YRLKDISTLL EKQHDLIKLI IQKMEIVSEA EDEDSNDLFQ HKFRKRQLEH
     KNSKWDTVLK AVKTNVPNPS TEKNNSFF
//
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