ID U3K1J5_FICAL Unreviewed; 1524 AA.
AC U3K1J5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
GN Name=ATP7B {ECO:0000313|Ensembl:ENSFALP00000008899.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008899.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008899.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008899.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR RefSeq; XP_016156068.1; XM_016300582.1.
DR STRING; 59894.ENSFALP00000008899; -.
DR Ensembl; ENSFALT00000008937.2; ENSFALP00000008899.2; ENSFALG00000008513.2.
DR GeneID; 101818277; -.
DR KEGG; fab:101818277; -.
DR CTD; 540; -.
DR eggNOG; KOG0207; Eukaryota.
DR GeneTree; ENSGT00940000155749; -.
DR HOGENOM; CLU_001771_0_1_1; -.
DR Proteomes; UP000016665; Chromosome 1.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR GO; GO:0043682; F:P-type divalent copper transporter activity; IEA:Ensembl.
DR GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0015677; P:copper ion import; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006878; P:intracellular copper ion homeostasis; IEA:Ensembl.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:Ensembl.
DR GO; GO:0015680; P:protein maturation by copper ion transfer; IEA:Ensembl.
DR GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR GO; GO:0051208; P:sequestering of calcium ion; IEA:Ensembl.
DR CDD; cd00371; HMA; 6.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 6.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR00003; copper ion binding protein; 5.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 6.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 6.
DR PROSITE; PS50846; HMA_2; 6.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT TRANSMEM 709..728
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 748..770
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 782..808
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 814..835
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 978..1001
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1021..1045
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1385..1406
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1412..1430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 126..192
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 211..277
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 323..389
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 421..487
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 543..609
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 619..685
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 493..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1524 AA; 164166 MW; 229AF0C99C9C2941 CRC64;
MERKLDNKMK RELSYLATLN DRNISLVAIR KQQAACDVPE LLIIGEKSKT ASPVKARRSL
QKEEKLLQSY SMGKTEVNTV ERQALSNIDS PPDCELKPTM KHNFAFDNMG YEESSETVPS
PPSQEHTVVV NIVGMTCQSC VQSIEGQISK VKGILRIKVS LEQNNAVIKY LQSEINPEQI
CQEILGMGFD ASVAEEKSTA ATVNLPSLKE AVVKLRVEGM TCQSCVTNIE GKIRKMHGVA
KIKVSLDNQE AIIAYHPYII QPDDLKRHIS DMGYDCTIKS KSAPLKLGAL DLQRLQNAKS
RETPASLESD GLDLLVTELG STATVTLQIE GMHCKSCVRN IEGNISDLPG IKSIEVSLEH
KCAVVEYSPD LITLSALQQA IEALPPGNFK VSLLNGSEAN KAPSGAFAYS ITRQPPQGTA
HTAVIKIGGM TCNSCAQSIE GAVSQRQGVQ RVAVSLAGGT GTIHYDPAVT SAEELRAAIE
DMGFDASVLT DTAAGEHRRQ PDGSKAAVQP RAPEPPRQGD ASDALPSSPH PDGSNQLSGA
TEEKCVLQIT GMTCASCVST IERNLQKEDG IVSVLVALMA GKAEIKYKPE LIQPLEIAQL
IQNLGFEATI MENDAETEGQ VELLITGMTC ASCVHNIESK LMRTNGIFSA SVALATSKAH
IQFDPEIIGP RDIIKVIKEI GFHASVAKRA PNAHNLDHKK EIQQWRKSFL FSLVFGIPVV
VIMIYMQIPN GEDHGSKVLE QNLIPGLSIL NLLFFILCTF VQFLGGWYFY VQAYKSLRHK
TANMDVLIVL ATTIAYLYSC VILIVAIIEK AEKSPVTFFD TPPMLFVFIA LGRWLEHIAK
GKTSEALAKL MSLQATEATV VTLGPGHSIV KEEQVPVELV QRGDIIKVVP GGKFPVDGKV
IDGSSMADES LITGEPMPVI KKPGSTVIAG SINAHGSLLV NATHVGNDTT LAQIVKLVEE
AQMSKAPIQQ LADKFSGYFV PFIIIISTVT LIVWITIGFV NFDIIKKYFP NQSKNISKAE
IILRFAFQTS ITVLSIACPC SLGLATPTAV MVGTGVAAQN GILIKGGKPL EMAHQIKTVM
FDKTGTITYG VPKVMRVLLM GDTAVLPLKK VLAVVGTAEA SSEHPLGMAV TKYCKEELGT
ESLGYCTDFQ AIPGCGISCK VGGVEAVLGT AEEGPNKQDA NRSAALGDKA AITPLESQGP
SASQKYSVLI GNREWMRRNG LNITNDVNDA MTNHEMKGQT AILVAIDGVL CGMIAIADTV
KQEAALAVHT LQSMGIDVVL LTGDNRKTAK AIATQVGIRK VFAEVLPSHK VAKVQELQSG
KKKVAMVGDG VNDSPALARA DVGIAIGTGT DVAIEAADVV LIRNDLLDVV ASIHLSKRTV
RRIRINLILA LIYNMLGIPI AAGVFMPVGL VLQPWMGSAA MAASSVSVLL SSLQLKCYKK
PDTESYEAQA QGRMKPLTPS QISVHIGMDD RRRDPSKPSP WDQTSQVSLS SLASDKLPKR
HGLLEEERGK WSSLINAADE EQYI
//