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Database: UniProt
Entry: U3K1J5_FICAL
LinkDB: U3K1J5_FICAL
Original site: U3K1J5_FICAL 
ID   U3K1J5_FICAL            Unreviewed;      1524 AA.
AC   U3K1J5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE            EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
GN   Name=ATP7B {ECO:0000313|Ensembl:ENSFALP00000008899.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008899.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000008899.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000008899.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC       {ECO:0000256|RuleBase:RU362081}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC       ECO:0000256|RuleBase:RU362081}.
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DR   RefSeq; XP_016156068.1; XM_016300582.1.
DR   STRING; 59894.ENSFALP00000008899; -.
DR   Ensembl; ENSFALT00000008937.2; ENSFALP00000008899.2; ENSFALG00000008513.2.
DR   GeneID; 101818277; -.
DR   KEGG; fab:101818277; -.
DR   CTD; 540; -.
DR   eggNOG; KOG0207; Eukaryota.
DR   GeneTree; ENSGT00940000155749; -.
DR   HOGENOM; CLU_001771_0_1_1; -.
DR   Proteomes; UP000016665; Chromosome 1.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0043682; F:P-type divalent copper transporter activity; IEA:Ensembl.
DR   GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0015677; P:copper ion import; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0006878; P:intracellular copper ion homeostasis; IEA:Ensembl.
DR   GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:Ensembl.
DR   GO; GO:0015680; P:protein maturation by copper ion transfer; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   GO; GO:0051208; P:sequestering of calcium ion; IEA:Ensembl.
DR   CDD; cd00371; HMA; 6.
DR   CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR   Gene3D; 3.30.70.100; -; 6.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006122; HMA_Cu_ion-bd.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 2.
DR   NCBIfam; TIGR00003; copper ion binding protein; 5.
DR   PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR   PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00403; HMA; 6.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00942; CUATPASEI.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS01047; HMA_1; 6.
DR   PROSITE; PS50846; HMA_2; 6.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU362081};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362081};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362081};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT   TRANSMEM        709..728
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        748..770
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        782..808
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        814..835
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        978..1001
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        1021..1045
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        1385..1406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        1412..1430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   DOMAIN          126..192
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          211..277
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          323..389
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          421..487
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          543..609
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          619..685
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   REGION          493..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1468..1494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1479..1493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1524 AA;  164166 MW;  229AF0C99C9C2941 CRC64;
     MERKLDNKMK RELSYLATLN DRNISLVAIR KQQAACDVPE LLIIGEKSKT ASPVKARRSL
     QKEEKLLQSY SMGKTEVNTV ERQALSNIDS PPDCELKPTM KHNFAFDNMG YEESSETVPS
     PPSQEHTVVV NIVGMTCQSC VQSIEGQISK VKGILRIKVS LEQNNAVIKY LQSEINPEQI
     CQEILGMGFD ASVAEEKSTA ATVNLPSLKE AVVKLRVEGM TCQSCVTNIE GKIRKMHGVA
     KIKVSLDNQE AIIAYHPYII QPDDLKRHIS DMGYDCTIKS KSAPLKLGAL DLQRLQNAKS
     RETPASLESD GLDLLVTELG STATVTLQIE GMHCKSCVRN IEGNISDLPG IKSIEVSLEH
     KCAVVEYSPD LITLSALQQA IEALPPGNFK VSLLNGSEAN KAPSGAFAYS ITRQPPQGTA
     HTAVIKIGGM TCNSCAQSIE GAVSQRQGVQ RVAVSLAGGT GTIHYDPAVT SAEELRAAIE
     DMGFDASVLT DTAAGEHRRQ PDGSKAAVQP RAPEPPRQGD ASDALPSSPH PDGSNQLSGA
     TEEKCVLQIT GMTCASCVST IERNLQKEDG IVSVLVALMA GKAEIKYKPE LIQPLEIAQL
     IQNLGFEATI MENDAETEGQ VELLITGMTC ASCVHNIESK LMRTNGIFSA SVALATSKAH
     IQFDPEIIGP RDIIKVIKEI GFHASVAKRA PNAHNLDHKK EIQQWRKSFL FSLVFGIPVV
     VIMIYMQIPN GEDHGSKVLE QNLIPGLSIL NLLFFILCTF VQFLGGWYFY VQAYKSLRHK
     TANMDVLIVL ATTIAYLYSC VILIVAIIEK AEKSPVTFFD TPPMLFVFIA LGRWLEHIAK
     GKTSEALAKL MSLQATEATV VTLGPGHSIV KEEQVPVELV QRGDIIKVVP GGKFPVDGKV
     IDGSSMADES LITGEPMPVI KKPGSTVIAG SINAHGSLLV NATHVGNDTT LAQIVKLVEE
     AQMSKAPIQQ LADKFSGYFV PFIIIISTVT LIVWITIGFV NFDIIKKYFP NQSKNISKAE
     IILRFAFQTS ITVLSIACPC SLGLATPTAV MVGTGVAAQN GILIKGGKPL EMAHQIKTVM
     FDKTGTITYG VPKVMRVLLM GDTAVLPLKK VLAVVGTAEA SSEHPLGMAV TKYCKEELGT
     ESLGYCTDFQ AIPGCGISCK VGGVEAVLGT AEEGPNKQDA NRSAALGDKA AITPLESQGP
     SASQKYSVLI GNREWMRRNG LNITNDVNDA MTNHEMKGQT AILVAIDGVL CGMIAIADTV
     KQEAALAVHT LQSMGIDVVL LTGDNRKTAK AIATQVGIRK VFAEVLPSHK VAKVQELQSG
     KKKVAMVGDG VNDSPALARA DVGIAIGTGT DVAIEAADVV LIRNDLLDVV ASIHLSKRTV
     RRIRINLILA LIYNMLGIPI AAGVFMPVGL VLQPWMGSAA MAASSVSVLL SSLQLKCYKK
     PDTESYEAQA QGRMKPLTPS QISVHIGMDD RRRDPSKPSP WDQTSQVSLS SLASDKLPKR
     HGLLEEERGK WSSLINAADE EQYI
//
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