ID U3K303_FICAL Unreviewed; 908 AA.
AC U3K303;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 4 {ECO:0000313|Ensembl:ENSFALP00000009407.1};
GN Name=FGD4 {ECO:0000313|Ensembl:ENSFALP00000009407.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000009407.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000009407.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000009407.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR AlphaFoldDB; U3K303; -.
DR STRING; 59894.ENSFALP00000009407; -.
DR Ensembl; ENSFALT00000009447.2; ENSFALP00000009407.1; ENSFALG00000009018.2.
DR eggNOG; KOG4424; Eukaryota.
DR GeneTree; ENSGT00940000155765; -.
DR HOGENOM; CLU_011755_1_0_1; -.
DR OMA; EEWIKTL; -.
DR Proteomes; UP000016665; Chromosome 1A.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd15741; FYVE_FGD1_2_4; 1.
DR CDD; cd15791; PH1_FDG4; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037742; FDG4_N_PH.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF98; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 347..534
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 563..662
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 701..757
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 702..752
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 785..882
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 104..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 101928 MW; 178847924D4B254E CRC64;
MQAGGERGAA LGAVRGALRT PRPLPQSAFL RFSAAPRTSG ADGADFRRVA FRRKCSAAPG
PGPARSTPAG SSVCPKPLIL SRACAASATA RLVEQNVRNE AAQGINGSVP LKKSPHSASS
PKPQVPPKPI HLQKATYQTP RHKALANQKP RMEEERPAAV SSVTKEKSSK VSDLINRFEG
GSSLNPSDLK KDSPVLHITK SQGRYASPQP KLPFQHSLQK QGNSNTDKTQ VAQLPTANGV
VAQEQPEDED QGLLDHGSAM SSPVLDDATD SSLINGEGES TRRESLQSVT VCEEQMLNSC
HRTPSSDTLL PSESEPLEIN TSVNEEPAEE SSKQEQPVEA KETDEQKRHK IANELLQTEK
AYVSRLDLLD GVFYSRLLEE ANRGSFPPEV INKIFSNISS INAFHSKFLL PELEKRMQEW
TTTPRIGDIL QKLAPFLKMY GEYVKNFDNA MELVKTWTER SPQFKFIIQD IQKEKVCGNL
TLQHHMLEPV QRIPRYEMLL KDYLRKLPQD SLDWKDAEKS LEIISTAASH SNGAIRKMEN
LKKLLEIYEM LGEEEDIVNP SNELIKEGQI LKLAARNTSA QERYLFLFNN MLLYCVPKFS
LVGSKFSVRT RVGIDGMKII ETHNEEYPHT FQVSGKERTL ELQASSEQDK EEWIKALQST
IEAFQQRNET FRNAIAKEYE DMPVEVSNAE LGKRAPRWIR DNEVTMCMKC KEPFNALTRR
RHHCRACGHV VCWKCSDYKA HLEYDGNKLN KVCKDCYHVI IGCTDSEEKK RKGILEIESA
EVSGNSVICS FLQYMEKSKP WQKAWCVIPK QEALVLYMYG APQDVKALAT IPLLGYTVDD
TPKSSDLPHS FKLTQSKSVH SFAADNEELK QKWLKVIHLA VKGETPECQN ELQVNLEEQP
ESSKRSEC
//
