ID U3K4Q0_FICAL Unreviewed; 721 AA.
AC U3K4Q0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Rho guanine nucleotide exchange factor 16 {ECO:0000313|Ensembl:ENSFALP00000010004.1};
GN Name=ARHGEF16 {ECO:0000313|Ensembl:ENSFALP00000010004.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010004.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000010004.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000010004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3K4Q0; -.
DR STRING; 59894.ENSFALP00000010004; -.
DR Ensembl; ENSFALT00000010044.2; ENSFALP00000010004.1; ENSFALG00000009597.2.
DR eggNOG; KOG3523; Eukaryota.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_012820_2_1_1; -.
DR OMA; FHPYVVY; -.
DR Proteomes; UP000016665; Chromosome 21.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 298..482
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 515..632
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 641..701
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 80211 MW; B2BD2A4E6E4DD369 CRC64;
MSPSTAGAPQ PDLCPWEAQL HPGSQCHPAV PTGLPHLGRA PPHHPQHREP GRAQGGDAAA
HPQKLGRLLQ AQEQPLPAPE LRGEPGAPEP RAEAGALKVG TQQLIPKSLA VSSKPKSSPS
RPQSFGASRE PLSPEPKLAA VPVLDPEAED EDEDDGGGAL KRSLRNMSYR AAMKGLGAEL
EPAKAAASLK PVSEDGSALP NRSPGRSKRT LGRKRVQKRG GSFKDQPRLY QEIRERGLNS
VSHESDEDLL EESLPEEPSP LGTAIVVQSY RPAQVTWSQL PEVLESGILQ RISAEERKRQ
EAMFEIITSE YSYMHSLSIL VGHFMRSEEL KETMTQTEHH HLFSNIGDIL TVSTSFFEDL
EKRHQEHLLI PDISDIVEEH ASKHFNPYIS YCSNEVYQQR TLDKLLTTNP LFKETLKQIE
RKPECGGLPM ISFLILPMQR VTRLPLLLDT VQQKTNAHTA AYGAATRAVK AISKLVKSCN
DGARAMERTE QMYTLQKQLE FGKKKPFPLV SVSRWLLKRG ELQLLLSEEA GLFRRGAGRL
CHLFLFNDVL IITKKKSEES YTVMNYATLD QVTVEKVESS DPPSPPPGKA GGHLLRVVLE
RDSEGRREEV LLSAETLSDR ARWMAALMHR EKEKPDTTPK GDLSQVEVTR AYLAKEADEL
SLQQADVVLV LGEEDGWCWG ERLRDGERGW FPQACARPIT SRVAAEGNVR RMERLRIETD
V
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