GenomeNet

Database: UniProt
Entry: U3K4Q0_FICAL
LinkDB: U3K4Q0_FICAL
Original site: U3K4Q0_FICAL 
ID   U3K4Q0_FICAL            Unreviewed;       721 AA.
AC   U3K4Q0;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=Rho guanine nucleotide exchange factor 16 {ECO:0000313|Ensembl:ENSFALP00000010004.1};
GN   Name=ARHGEF16 {ECO:0000313|Ensembl:ENSFALP00000010004.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010004.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000010004.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000010004.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; U3K4Q0; -.
DR   STRING; 59894.ENSFALP00000010004; -.
DR   Ensembl; ENSFALT00000010044.2; ENSFALP00000010004.1; ENSFALG00000009597.2.
DR   eggNOG; KOG3523; Eukaryota.
DR   GeneTree; ENSGT01030000234571; -.
DR   HOGENOM; CLU_012820_2_1_1; -.
DR   OMA; FHPYVVY; -.
DR   Proteomes; UP000016665; Chromosome 21.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR   GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   CDD; cd01221; PH_ephexin; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11938; SH3_ARHGEF16_26; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR047270; PH_ephexin.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12845:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          298..482
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          515..632
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          641..701
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          1..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  80211 MW;  B2BD2A4E6E4DD369 CRC64;
     MSPSTAGAPQ PDLCPWEAQL HPGSQCHPAV PTGLPHLGRA PPHHPQHREP GRAQGGDAAA
     HPQKLGRLLQ AQEQPLPAPE LRGEPGAPEP RAEAGALKVG TQQLIPKSLA VSSKPKSSPS
     RPQSFGASRE PLSPEPKLAA VPVLDPEAED EDEDDGGGAL KRSLRNMSYR AAMKGLGAEL
     EPAKAAASLK PVSEDGSALP NRSPGRSKRT LGRKRVQKRG GSFKDQPRLY QEIRERGLNS
     VSHESDEDLL EESLPEEPSP LGTAIVVQSY RPAQVTWSQL PEVLESGILQ RISAEERKRQ
     EAMFEIITSE YSYMHSLSIL VGHFMRSEEL KETMTQTEHH HLFSNIGDIL TVSTSFFEDL
     EKRHQEHLLI PDISDIVEEH ASKHFNPYIS YCSNEVYQQR TLDKLLTTNP LFKETLKQIE
     RKPECGGLPM ISFLILPMQR VTRLPLLLDT VQQKTNAHTA AYGAATRAVK AISKLVKSCN
     DGARAMERTE QMYTLQKQLE FGKKKPFPLV SVSRWLLKRG ELQLLLSEEA GLFRRGAGRL
     CHLFLFNDVL IITKKKSEES YTVMNYATLD QVTVEKVESS DPPSPPPGKA GGHLLRVVLE
     RDSEGRREEV LLSAETLSDR ARWMAALMHR EKEKPDTTPK GDLSQVEVTR AYLAKEADEL
     SLQQADVVLV LGEEDGWCWG ERLRDGERGW FPQACARPIT SRVAAEGNVR RMERLRIETD
     V
//
DBGET integrated database retrieval system