ID U3K520_FICAL Unreviewed; 1760 AA.
AC U3K520;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Tubulin gamma complex associated protein 6 {ECO:0000313|Ensembl:ENSFALP00000010124.2};
GN Name=TUBGCP6 {ECO:0000313|Ensembl:ENSFALP00000010124.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010124.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000010124.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000010124.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337}.
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DR STRING; 59894.ENSFALP00000010124; -.
DR Ensembl; ENSFALT00000010164.2; ENSFALP00000010124.2; ENSFALG00000009698.2.
DR eggNOG; KOG2000; Eukaryota.
DR GeneTree; ENSGT00940000157810; -.
DR HOGENOM; CLU_002518_0_0_1; -.
DR Proteomes; UP000016665; Chromosome 1A.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000931; C:gamma-tubulin ring complex; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0007020; P:microtubule nucleation; IEA:Ensembl.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR045818; GCP6_N.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF70; GAMMA-TUBULIN COMPLEX COMPONENT 6; 1.
DR Pfam; PF19340; GCP6_N; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 444..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..344
FT /note="Gamma-tubulin complex component 6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19340"
FT DOMAIN 355..617
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 1436..1719
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 258..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1760 AA; 199995 MW; A846EAFBDB3CDBDD CRC64;
MESITQLFSD LCEAHLTGLP WKVHLGRQKI SKRRAKQNLK RIAYNALFMN LFQDEARKLQ
SNVSRLPVKN KILMLSFNLR VAGLGAQADR LENLVEELET AECLPFTEVN SVLDLLVQLA
GTGPPQLVPQ KKDYFLNNKY VGRNVKYQGY DYYDVSVFEA DIQSLITNEE CQFNDTIQQT
LQIMEAAPGT GLPAIGLFSQ SCPAGDKFEK ETRVSLFGAL VHSRTYDMDI KLDLPPVPDN
ADLSGLAIKV PQSIDQSEDE GFQSASNLTP DSQSEPSITP DIDLWDAVLT YGPSKRRCWE
RIGYPPGKKE EPYLTEAGRE AFDKFYKLRE GELQLFTNTV LQLPQLVLVK EPELVKDVLN
VLIGVVSTTF SLNQAAQSFV IREGVYVSGT SPETMHNLLS EVAEYGTYYT RLSRFSLQPV
LDSSYSKGLV FQAFTSGLRK YLQYYRACVL STPPTLSLLT ISFLFRKLGR QLRYLAELCG
IGTTALVISG GAGASFPTGV KLLSYLYKEA LNNCSNEHYP VLLSLLKTSC EPYTRFIYDW
VYSGVFRDVY GEFMIQVNED YLCFRDKHYW THGYVLISKE VEDCVPVFLK HIANDVYICG
KTINLLKLCC PRHYICWSDI PVPRISVIFS LEELKEIERD CAVYVGRMER IARYSSISKE
EKDLRMEIAK QELIVHARET ASKVLKAISD KQISERMALD AKKREQFQKL KEQFAKDQER
RLAIKQEEID DDFSYARELR EREKRLKALE EELEKKARQE LIDHYSKLSD DAARREQRTL
WKIQRHKLET ARLKFLLEDQ KRIEEMLEKL PDGNYRRKLD IIPYKECQLA LDKNPVEKDP
PSQVSFVKPL HSNETVGRKE PEPEQGYAAS ADKALPTAEP ENNNADEHFQ PKATGSESNL
QNSEEACSAE PLPESNVNIE DFLSKSQDEQ SIAVRVQGSL LDEAFQNINS DLSETLQVSE
SQPVLRGAPE EDNAPLHQQS EYDFNTVLRP SAAWQGHVGV GENVFDVDNR RPRWNIHGHA
SDSNIRVGEY VPQVDAYQPH PSPHGHSSDS HIKSSSYTSE VEPRRPRWNI HGHVSEAHIK
IGEYASETAT SRPRWNVHGH ASEANIKIGE YVSNVAPTRP RWSSHGHASD ANIKIGENVS
EVVSARPRWN IHGHASQSHI KIGELVSDTE PVKSRWSPFG HASQSSIQIG KWAPSVENDP
IPHRKTISGS SSDSTVQTLL YSEELPPAEG SRKEAEPSQV KEETLPPSQI SDSVTDFPDA
NIKDDKKENS KEKNQEVIAD VVNKDPSPDS SQNLQREEPE KAVPQDTVPQ ETLSSEANAP
TTKEEDGEEE DTWKKEQAYL KALSDQYCIE KYQDSYDLMS EPPVSHLLHH VIPRSYTFPV
DPMVQSATDE TAVQLSELLS LPVLMKRSIT APLVSHVSLV NKAIVDYYFV ELNVEKHFEA
LRHFLLMEDG EFAQSLSDLL FEKLGSGQTP GELLNPLVLN SILNKALQYS LHGDTQLASN
LSFALKYLPE MFKPNAPDVL SCLELRYKVD WPLNIVITES CMNKYNKIFS FLLQLKHMVW
TLKDVWFHLK RTALVSSASN SVQFRQLQLY KHEMQHFVKV IQGYIANQIL HVTWCEFGNK
LSSVGNLEEI HRTHAEYLNK AIFRGLLTEK AAPVMNIIHS IFSLILKFRS QLISQSWSFD
AGKQMAVHPN FGLMQQSYNT FKYYSHFLFK GCPKMVSKDQ KQIFQDELEW LLPNSTGNQN
TCGSHLSPYY EIYACFMDRD
//
