ID U3K723_FICAL Unreviewed; 216 AA.
AC U3K723;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Tissue factor pathway inhibitor 2 {ECO:0000313|Ensembl:ENSFALP00000010827.2};
GN Name=TFPI2 {ECO:0000313|Ensembl:ENSFALP00000010827.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010827.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000010827.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000010827.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3K723; -.
DR STRING; 59894.ENSFALP00000010827; -.
DR Ensembl; ENSFALT00000010870.2; ENSFALP00000010827.2; ENSFALG00000010381.2.
DR eggNOG; KOG4295; Eukaryota.
DR GeneTree; ENSGT00940000159917; -.
DR HOGENOM; CLU_058441_1_0_1; -.
DR Proteomes; UP000016665; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd22615; Kunitz_TFPI1_TFPI2_3-like; 1.
DR CDD; cd22616; Kunitz_TFPI2_1-like; 1.
DR CDD; cd22617; Kunitz_TFPI2_2-like; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 3.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008296; TFPI-like.
DR PANTHER; PTHR10083; KUNITZ-TYPE PROTEASE INHIBITOR-RELATED; 1.
DR PANTHER; PTHR10083:SF217; PROTEIN CBG23496; 1.
DR Pfam; PF00014; Kunitz_BPTI; 3.
DR PIRSF; PIRSF001620; TFPI; 2.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 3.
DR SUPFAM; SSF57362; BPTI-like; 3.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 3.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 24..74
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 84..134
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 144..194
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 216 AA; 24399 MW; 8FA10CA40A319025 CRC64;
DLPAVPGPGP SPAAAVSAEK QRACLLPPDD GPCRALVPRW YYDRHTQSCQ QFTYGGCYGN
ANNFLTFDDC EKSCWTIKKV PKLCRMEADG GPCRSYLRRY AFNLSSMRCE EFIYGGCYGN
ANNFRDLQSC VDHCLPEKTG PLLCYSPKDE GLCSSSVPRY YYDIKTKSCK EFRYTGCGGN
ANNFVTETDC YNVCRNGKDR EKHNCMLLPR TFRKHA
//
