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Database: UniProt
Entry: U3K751_FICAL
LinkDB: U3K751_FICAL
Original site: U3K751_FICAL 
ID   U3K751_FICAL            Unreviewed;       636 AA.
AC   U3K751;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=Mitochondrial-processing peptidase subunit beta {ECO:0000256|ARBA:ARBA00020510};
DE            EC=3.4.24.64 {ECO:0000256|ARBA:ARBA00012299};
DE   AltName: Full=Beta-MPP {ECO:0000256|ARBA:ARBA00031018};
GN   Name=PMPCB {ECO:0000313|Ensembl:ENSFALP00000010855.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010855.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000010855.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000010855.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of N-terminal transit peptides from precursor proteins
CC         imported into the mitochondrion, typically with Arg in position P2.;
CC         EC=3.4.24.64; Evidence={ECO:0000256|ARBA:ARBA00001098};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBUNIT: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits,
CC       forming the mitochondrial processing protease (MPP) in which PMPCA is
CC       involved in substrate recognition and binding and PMPCB is the
CC       catalytic subunit. {ECO:0000256|ARBA:ARBA00011587}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|RuleBase:RU004447}.
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DR   AlphaFoldDB; U3K751; -.
DR   STRING; 59894.ENSFALP00000010855; -.
DR   Ensembl; ENSFALT00000010899.2; ENSFALP00000010855.2; ENSFALG00000010410.2.
DR   eggNOG; KOG0960; Eukaryota.
DR   GeneTree; ENSGT00940000156608; -.
DR   HOGENOM; CLU_009902_4_2_1; -.
DR   Proteomes; UP000016665; Chromosome 1A.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IEA:Ensembl.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   PANTHER; PTHR11851:SF103; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT BETA; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          220..365
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          371..555
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  69906 MW;  E2A2313164E5EC3F CRC64;
     MAAGGRVWGY GEPRPHGGTA SGLPARSAPG GRTAPRHRRK GSAQLCSRPV PMGGKRCLQS
     RLGALECSDR QVLRRKFPGL GSQQSGVLPP SPAVPALTGH ELSGRGHPPA EQSALQAPVS
     LRPWEEAHRY SHASQSASDV PKANMEANVF KVVEKCPQHC YLLMNREGMN QRIKEWWLSW
     LSEQCVHVGT GRLTVSKAAT EVILNVPETR VSPLENGLQV ASEDSGLSTC TVGLWIDAGS
     RYENEKNNGT AHFLEHMAFK GTKKRSQLDL ELEIENMGAH LNAYTSREQT VYYAKAFSKD
     LPRAVEILAD IIQNSTLGEA EIERERGVIL REMQEVETNL QEVVFDYLHA TAYQNTALGR
     TILGPTENIK SINRNDLVEY ITTHYKGPRM VLAAAGGVSH DELLDLAKCH FGNLPSAPEG
     GLPPLPPCSF TGSEIRIRDD KMPLAHLAIA VEAAGWADPD TIPLMVANTL IGNWDRSFGG
     GVNLSSKLAQ TACHGNLCHS FQSFNTCYTD TGLWGLYMVC EPSTIEDMVH FVQREWIRLC
     TSVTENEVAR AKNLLKTNML LQLDGSTPIC EDIGRQMLCY KRRIPIPELE ARIEAIDAQT
     IREICTKYIC DKHPAVAAVG PIEQLPEYSK ICSGMN
//
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