ID U3K7B2_FICAL Unreviewed; 467 AA.
AC U3K7B2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=FA complementation group I {ECO:0000313|Ensembl:ENSFALP00000010916.2};
GN Name=FANCI {ECO:0000313|Ensembl:ENSFALP00000010916.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010916.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000010916.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000010916.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4
CC family. {ECO:0000256|ARBA:ARBA00010884}.
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DR AlphaFoldDB; U3K7B2; -.
DR MEROPS; S33.A56; -.
DR Ensembl; ENSFALT00000010960.2; ENSFALP00000010916.2; ENSFALG00000010491.2.
DR eggNOG; KOG1838; Eukaryota.
DR GeneTree; ENSGT00390000005855; -.
DR HOGENOM; CLU_032487_5_0_1; -.
DR OrthoDB; 4242155at2759; -.
DR Proteomes; UP000016665; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000952; AB_hydrolase_4_CS.
DR InterPro; IPR012020; ABHD4.
DR InterPro; IPR029305; FANCI_S1-cap.
DR PANTHER; PTHR10794; ABHYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10794:SF45; MONOACYLGLYCEROL LIPASE ABHD2; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF14674; FANCI_S1-cap; 1.
DR PIRSF; PIRSF005211; Ab_hydro_YheT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01133; UPF0017; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT DOMAIN 127..383
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT DOMAIN 399..423
FT /note="FANCI solenoid 1 cap"
FT /evidence="ECO:0000259|Pfam:PF14674"
SQ SEQUENCE 467 AA; 52484 MW; FA5AAD672433D73F CRC64;
MSAILETSEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPELIYQDSA LARFLLKSCP
LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGLRKY LTMPDGATAT FDLFEPRSEH
CTADDVTMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG
CTWEFGAMVN YIKKTYPQTQ LVVVGFSLGG NIVCKYLGES QANQERVLCC VSVCQGYSAL
RAQETFMQWD HCRRFYNFLM ADNMKKIILS HRQVLFGDNN MKKPQSLSDA DLGKLYTATS
LMQIDDNVMR KFHGYSSLKE YYEEESCLQY LHRIYVPLLL VNAADDPLVH ESLLSIPRAL
SEKRENVMHV LPLHGGHLGF FEGSVLFPEP LTWMDKLVLG DMVTRQALKG RETAALLRGI
FKGGRCVSCA RCVQHREVSL VVRNPLLRAV AGKHDILKYV RGGSKPD
//
