ID U3K8H3_FICAL Unreviewed; 763 AA.
AC U3K8H3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Leucine rich repeat and fibronectin type III domain containing 2 {ECO:0000313|Ensembl:ENSFALP00000011327.1};
GN Name=LRFN2 {ECO:0000313|Ensembl:ENSFALP00000011327.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000011327.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000011327.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000011327.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_005043281.1; XM_005043224.1.
DR AlphaFoldDB; U3K8H3; -.
DR STRING; 59894.ENSFALP00000011327; -.
DR Ensembl; ENSFALT00000011372.2; ENSFALP00000011327.1; ENSFALG00000010855.2.
DR GeneID; 101810930; -.
DR KEGG; fab:101810930; -.
DR CTD; 57497; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156417; -.
DR HOGENOM; CLU_016998_1_0_1; -.
DR OMA; ELMDFSA; -.
DR OrthoDB; 2942402at2759; -.
DR Proteomes; UP000016665; Chromosome 3.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0099175; P:regulation of postsynapse organization; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR CDD; cd05764; IgI_SALM5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF6; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..763
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004646219"
FT TRANSMEM 520..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 288..374
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 412..509
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 383..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 84718 MW; D501001D61F56141 CRC64;
MEKLLCGILV FGMAVTVNAC PKYCVCQNLS ESLGTLCPSK GLLFVPLDID RRTVELRLGG
NFIINISRQD FANMSGLVDL TLSRNTISYI QPYSFTDLES LRSLHLDSNR LPEIEEDTLR
GLINLQHLIL NNNQLSSISD DAFEDFLLTL EDLDLSYNNL RSIPWESIRK MINLHQLSLD
HNLIDYITEG TFADLQKLAR LDLTSNRLQK LPPDPIFARS QVIPLVVTPF SPPLSLSFGG
NPLHCNCELL WLRRLDRDDD METCASPPSL KGRYFWYIRE EEFVCEPPLI TQHTHKLLVL
EGQTATLKCK AIGDPTPIIH WVAPDDRLIG NSSRTAVYDN GTLDIHITTS KDYGTFTCIA
ANAAGESTAT IELSIVQLPH LSNGTGKAAP PKSRLSDITS STKSNRGETK GPPERAVLVS
DVTTTSALVK WTVSKSAPRV KMYQLQYNCS DDEVLIYRMI PATNKAFVVT NLVSGTGYDL
CVLAMWDDTA TTLTATNIVG CAQFFTKEDY PQCQSMHSQF LGGTMILIIG GIIVATLLVF
IVILMVRYKV CSNSQGKMSN VSNVYSQTNG AQPVQNGVLP QVNPKVVVRN ELMEFNCQSA
RSSISSSSSS ANSRDCDNYS LQSEQGTLSS KWRPPSRSKH NIDRLMGAFA SLELKCQKKE
EMTDSRTSTV ARHSDKEPLL GQTESKFRSF LMLPLEGKTK RSHSFDMGDF ATSQCCTYPK
KITNIWTKRS LSVNGMLLQY DDSDLTGAKG TFGSSEWVME STV
//
