ID   U3K945_FICAL            Unreviewed;       866 AA.
AC   U3K945;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Regulatory factor X6 {ECO:0000313|Ensembl:ENSFALP00000011549.2};
GN   Name=RFX6 {ECO:0000313|Ensembl:ENSFALP00000011549.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000011549.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000011549.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000011549.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_005043898.1; XM_005043841.1.
DR   AlphaFoldDB; U3K945; -.
DR   STRING; 59894.ENSFALP00000011549; -.
DR   Ensembl; ENSFALT00000011596.2; ENSFALP00000011549.2; ENSFALG00000011057.2.
DR   GeneID; 101819153; -.
DR   KEGG; fab:101819153; -.
DR   CTD; 222546; -.
DR   eggNOG; KOG3712; Eukaryota.
DR   GeneTree; ENSGT01050000244879; -.
DR   HOGENOM; CLU_013981_0_0_1; -.
DR   Proteomes; UP000016665; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0003310; P:pancreatic A cell differentiation; IEA:Ensembl.
DR   GO; GO:0003311; P:pancreatic D cell differentiation; IEA:Ensembl.
DR   GO; GO:0090104; P:pancreatic epsilon cell differentiation; IEA:Ensembl.
DR   GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:0003309; P:type B pancreatic cell differentiation; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619:SF28; DNA-BINDING PROTEIN RFX6; 1.
DR   PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          63..138
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000259|PROSITE:PS51526"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   866 AA;  95936 MW;  E6307EF663D80890 CRC64;
     MPLGVSSCPP RRSETRLGSE ALSSEEEDAD ARDGALTAAD QSPSSKKSIT QIMKDKKKQT
     QLTLQWLEEN YIVCEGVCLP RCILYAHYLD FCRKEKLEPA CAATFGKTIR QKFPLLTTRR
     LGTRGHSKYH YYGIGIKESS AYYHSVYSGK GLTRFSGSKL KNEGGFTRKY SLSSKTGTLL
     PEFPSAQHLL LQGCISKDKV DTLIMMYKTH CQCVLDNAIN GNFEEIQHFL LHFWQGMPDH
     LLPLLENPII IDIFCVCDSI LYKVLTDVLI PATMQEMPES LLADIRSFAK NWEQWVASSL
     ENLPESLIDK KLPIARRFVS SLKRQTSFLH LAQIARPALF DQHVVNSMVS DIEKVDLNSI
     GSQALLAVSG STDSDGEVYS EYDSITVFQE LKDLLKKNAT VESFIEWLDT VVEQRVIKAS
     KQNGRSLKKR AQDFLLKWSF FGARVMHNLT LNNASSFGSF HLIRMLLDEY ILLAMETQFN
     NDKEQELQNL LDKYMKNLDA SKATFTASPS SCFLANRNKA APLPSDTSVK NECLGEQTYM
     SLPAGQPSSA PSGLNPFTTG DGESMQLTDQ MELSQSTGHL MTPPISPAMV SRGSVINQGP
     MAVRPPSVGP MLSTHSQCSS YSEPLYQALS QTNQNYYGNN SNYQAMFRTQ AHSASGVYDH
     RAEPGRFNAL SEQQFSRDYF SNSCSVSPYN ARSPSSYGPS SMSQDTHNMQ FLNTGSFNFL
     NNSVSTCPGA AYPANASNGY YGNSINYSES HRLGTMVDQH VSVISSVSSI RPLPSYSDIH
     DPLNILDDSR RKQTGSYYTE SSPSIVCRTP MPSNLQTTSA SQCMYGTSGQ FPSQENLEVL
     APPSRDMVPS LPPINTVFMG AAAGGT
//