ID U3KA61_FICAL Unreviewed; 638 AA.
AC U3KA61;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
GN Name=TUBGCP4 {ECO:0000313|Ensembl:ENSFALP00000011915.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000011915.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000011915.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000011915.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC at the centrosome. {ECO:0000256|RuleBase:RU363050}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
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DR AlphaFoldDB; U3KA61; -.
DR STRING; 59894.ENSFALP00000011915; -.
DR Ensembl; ENSFALT00000011964.2; ENSFALP00000011915.2; ENSFALG00000011417.2.
DR eggNOG; KOG2065; Eukaryota.
DR GeneTree; ENSGT00940000156677; -.
DR HOGENOM; CLU_012029_0_0_1; -.
DR OrthoDB; 226505at2759; -.
DR Proteomes; UP000016665; Chromosome 10.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF27; GAMMA-TUBULIN COMPLEX COMPONENT 4; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 2..347
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 350..600
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 208..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 73288 MW; EADEFE343CCAB48E CRC64;
MIHELLLALS GYPGAAFTWS KRGGLQVSQE LPFLHPSETS VLNRLCRLGT DYIRFAEFVE
QYTGHVQQQD HHPSQQNQSG LHGIYLRAFC TGLDSVLQPY RQALLDLEQE FLADPHLSIS
HVNYSLDQFQ LLFPSVMVMV EQIKTQKIHG CQILETVHKH SCGGLPPVRS ALEKILAVCH
GVMYKQLSAW MLHGLLLDQH EEFFIKQGPS SGNVPSQPED DDDDLGIGGL TGKQLRELQD
LRLIEEENML APSLKQFSLR VEMLPSYIPV RVAEKILFVG ESVQMFENQN VNLTRKGSIL
KNQEDTFAAE LHRLKQQPLF SLVDFESVVD WIRSTVAEHL WKLMVEESDL LGQLKIIKDF
YLLGRGELFQ AFIDTAQHML KTPPTAVTEH DVNIAFQQSA HKVLLDDDNL LPLLHLTIEY
HGKEHKDTCQ SREGPSRELS PREAPTSGWA ALGLSYKVQW PLHILFTPAV LEKYNVVFKY
LLSVRRVQAE LQHCWALQMQ RKHLKSNRTD AIKWRLRDHM AFLVDNLQYY LQVDVLESQF
SQLLQQINAT RDFESIRLAH DHFLSNLLAQ SFILLKPVFH CLNEILDLCH SFCSLVSQNL
GPLDERGAAQ LSILVKFSLS WKFFVHRKAE RGKYWNRR
//
