ID U3KB59_FICAL Unreviewed; 769 AA.
AC U3KB59;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase 3 {ECO:0000313|Ensembl:ENSFALP00000012263.2};
GN Name=ENPP3 {ECO:0000313|Ensembl:ENSFALP00000012263.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012263.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000012263.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000012263.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; U3KB59; -.
DR Ensembl; ENSFALT00000012312.2; ENSFALP00000012263.2; ENSFALG00000011732.2.
DR eggNOG; KOG2645; Eukaryota.
DR GeneTree; ENSGT00940000159640; -.
DR HOGENOM; CLU_012256_0_1_1; -.
DR Proteomes; UP000016665; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 3.30.1360.180; -; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF107; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 3; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 2.
DR Pfam; PF01033; Somatomedin_B; 2.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 43..86
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 87..131
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 769 AA; 87492 MW; 56A9175E46DA84E5 CRC64;
APHSLALPGH ESSHFSLQPT SMICLTDLPG TGLSEHSASL LLPTASCRHR CSEPHGKGVP
GCQCDSSCKE RQDCCWDYED TCVEPTRSWK CTNFRCGETR IPGSYCSCSD DCLQKKDCCV
NYYSICKGET SWVEEPCMSI ETSQCPAGFP HPPLILFSMD GFRAEYLETW SSLLPNIEKL
KMCGTHSKYM RAVYPTKTFP NHYTIVTGLY PESHGIIDNN MYDVGLNAHF SLSGEEKFKP
AWWKGQPVWL TAMYQNLTAG TFFWPGSDVP IEGTYPTLYT IYNGPDIYTL YIEEPDSSGH
SFGPVSAGVI KALQAADQAL GMLMDGLKQR NLHKCVNLIV LADHGMEKTY CEQLEYMTNY
FKEVDFYMYA GPAARIRAQN VPDNYYTFDS EGIVKNLTCR RSPQHFKPYL TPDLPKRFHY
ANNVRIDKVH LLVDRQWLAV RDESYTFCGG GDHGYNNEFK SMEAIFLAYG PNFKEKTEVD
AFENIEVYNL MCVNKASSSH LPYGRPKVLQ KENVYCLLSH HQYVSGYSSD IWMPLWTAYT
VNKPENTSPL PPTVSDCLRA DVRIPAAWSQ NCSDYPEGLT LTHSFLYPPN YNSSVLEQYD
ALLTSNIVPM YKAFKEIWDY FHDVLLQKYA RERNGVNVIS GPVFDYNYDG HFDSPEEIKQ
YVNNTKIPVP THYYVILTSC KNTSYTPLNC SGSLDALSFI IPHRPDNTES CAENKMPSEW
VEERVQAHAA RVRDVELLTG LDFYQERNES VSEILRLKTF LPIFEIESN
//