ID U3KCS1_FICAL Unreviewed; 577 AA.
AC U3KCS1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN Name=MCCC2 {ECO:0000313|Ensembl:ENSFALP00000012825.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012825.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000012825.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000012825.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR RefSeq; XP_005061119.1; XM_005061062.1.
DR STRING; 59894.ENSFALP00000012825; -.
DR Ensembl; ENSFALT00000012875.2; ENSFALP00000012825.1; ENSFALG00000012282.2.
DR Ensembl; ENSFALT00000028305.1; ENSFALP00000028832.1; ENSFALG00000012282.2.
DR Ensembl; ENSFALT00000043383.1; ENSFALP00000030905.1; ENSFALG00000012282.2.
DR GeneID; 101821035; -.
DR KEGG; fab:101821035; -.
DR CTD; 64087; -.
DR eggNOG; KOG0540; Eukaryota.
DR GeneTree; ENSGT00940000155949; -.
DR HOGENOM; CLU_018822_0_1_1; -.
DR OMA; AYLPIMS; -.
DR OrthoDB; 5474505at2759; -.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000016665; Chromosome Z.
DR GO; GO:0002169; C:3-methylcrotonyl-CoA carboxylase complex, mitochondrial; IEA:Ensembl.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0004485; F:methylcrotonoyl-CoA carboxylase activity; IEA:Ensembl.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 63..320
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 320..569
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 62490 MW; F935527FD54F67AB CRC64;
MEERSRGAAG RGESPSARAW PSLRAEPSGT GERRGLPRRG CLGAVRSACQ LLLPVRLENY
ERMKALVTEL QEQAEKIRLG GGEKARKLHT SRGKLLPRER IDKLIDPGSP FLEFSQFAGH
QLYGNEEVPA GGIITGIGRV SGTECLIVAN DATVKGGTYY PITVKKHLRA QEIAMQNHLP
CLYLVDSGGA NLPRQAEVFP DRDHFGRIFY NQAVMSSQGI PQIAVVMGSC TAGGAYVPAM
ADESIIVGKQ GTIFLGGPPL VKAATGEQVS AEDLGGADLH CRKSGVTDHY ALDDNHALHL
ARKVVRSLNL QKKVDVTIEP SEEPLFPADE IYGIVGDQLK RNFDVKEVIA RIVDGSRFDE
FKALYGDTLV TGFARIFGYP VGIIGNNGVL FSESAKKGTH FIQLCCQRNI PIVFLQNITG
FMVGREYEAG GIAKDGAKMV TAVACANVPK ITVIIGGSYG AGNYGMCGRA YSPRFLYMWP
NARISVMGGE QAATVLATIA KDQKAREGKQ LSEADEAALK EPIIRRFEEE GNPYYSSARL
WDDGIIDPAD TRLVLGLSLS AALNAPTKKT EFGVFRM
//
