ID   U3KD77_FICAL            Unreviewed;       632 AA.
AC   U3KD77;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=SHC adaptor protein 3 {ECO:0000313|Ensembl:ENSFALP00000012981.1};
GN   Name=SHC3 {ECO:0000313|Ensembl:ENSFALP00000012981.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012981.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000012981.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000012981.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_005061026.1; XM_005060969.1.
DR   AlphaFoldDB; U3KD77; -.
DR   STRING; 59894.ENSFALP00000012981; -.
DR   Ensembl; ENSFALT00000013033.2; ENSFALP00000012981.1; ENSFALG00000012426.2.
DR   GeneID; 101820104; -.
DR   KEGG; fab:101820104; -.
DR   CTD; 53358; -.
DR   eggNOG; KOG3697; Eukaryota.
DR   GeneTree; ENSGT00950000182870; -.
DR   HOGENOM; CLU_029532_2_0_1; -.
DR   OMA; NTQRIPQ; -.
DR   OrthoDB; 2903566at2759; -.
DR   Proteomes; UP000016665; Chromosome Z.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd01209; PTB_Shc; 1.
DR   CDD; cd09925; SH2_SHC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006019; PID_Shc-like.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035676; SHC_SH2.
DR   PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR   PANTHER; PTHR10337:SF4; SHC-TRANSFORMING PROTEIN 3; 1.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00629; SHCPIDOMAIN.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          171..337
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          537..628
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          508..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  69503 MW;  D66C246AC0602AF3 CRC64;
     MLQRTKYNRF RNDSVTSVDD LFHNLPMNSK ISAVATTSAS PSYLVSPEVL HKDQEDGPTT
     LCTLIHKVSH LKLSSTGSLL GIKNLSSAVK ELAVSKLQGS SSASSSAAGA SDNTCNLVSA
     TSCSQQDVSK MSMGKKARSE EMHLGSEDWN QTSSFVDKSS RGWLHSSEKI LGPGVTYIVK
     YLGCIEVLRS MRSLDFSTRM QVAREAISRV CEAMPGAKRA FKKRKPPSKV LSSILGKSNL
     QFAGTSIMLN ISTSSLNLMN PDTKQIIANH HMQSISFASG GDPDTSDYIA YVAKDPVNRR
     ACHILECCDG LAQDVISTIG QAFELRFKQY LQCPSKTPTF PDRMQSFEDP WMEEDNEATE
     HHYYNNIPNK MPPPGGFLDA RLKARLATAA DTAHSASGVG GEQIYYQSHH LGEKFSEEWH
     HKPVKQGSLD ICSMSEEKSE VAPAAELPIY VNTQHINRED LLALQADAES TFSGTAEDAE
     ASSPGKDLFD MKPFEDALKS QTSEAMMKKS TSTGCTSPPL SRAPVWTEAE ELSTEPWYQG
     EMSRKEAEQL LKKCGDFLVR KSTTNPGSYV LTGMHKGQAK HLLLVDPEGT VRTKDRVFDS
     ISHLINYHLE NNLPIVSSVS ELCLQQPAER KQ
//