ID U3KEF3_FICAL Unreviewed; 1516 AA.
AC U3KEF3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Zinc finger FYVE domain-containing protein {ECO:0000256|PIRNR:PIRNR037289};
GN Name=ZFYVE16 {ECO:0000313|Ensembl:ENSFALP00000013407.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000013407.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000013407.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000013407.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037289}. Early
CC endosome membrane {ECO:0000256|PIRNR:PIRNR037289}.
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DR RefSeq; XP_005061340.1; XM_005061283.1.
DR RefSeq; XP_005061341.1; XM_005061284.2.
DR STRING; 59894.ENSFALP00000013407; -.
DR Ensembl; ENSFALT00000013463.2; ENSFALP00000013407.1; ENSFALG00000012844.2.
DR GeneID; 101812605; -.
DR KEGG; fab:101812605; -.
DR CTD; 9765; -.
DR eggNOG; KOG1841; Eukaryota.
DR GeneTree; ENSGT00940000154290; -.
DR HOGENOM; CLU_004326_0_0_1; -.
DR OMA; GIDKYVC; -.
DR OrthoDB; 3061552at2759; -.
DR Proteomes; UP000016665; Chromosome Z.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR CDD; cd15729; FYVE_endofin; 1.
DR Gene3D; 3.30.500.40; -; 1.
DR Gene3D; 3.30.1360.220; Domain of unknown function (DUF3480), N-terminal subdomain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR022557; SARA-like_C.
DR InterPro; IPR035438; SARA/endofin.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46319; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46319:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 16; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF11979; SARA_C; 1.
DR PIRSF; PIRSF037289; SARA/endofin; 1.
DR SMART; SM01421; DUF3480; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037289};
KW Endosome {ECO:0000256|PIRNR:PIRNR037289};
KW Membrane {ECO:0000256|PIRNR:PIRNR037289};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR037289};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 720..778
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 266..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1516 AA; 163554 MW; F1F82181A3048C12 CRC64;
MDSYFKAAVC DLDKLLDEFE RNTDECECFR TPQNPYDSKL SSVLDCLEHA DPRAGQPEDP
ARCPAPEQSS LCAPADTGDV LSYSPPREKG VAGPDLLSTV DSGPLSETQA LKLGRCSIPV
CDLVSDTANL KHSVAAAEGP QKLQPDHLQC SQAGCGVSCV PVPACVTSPG CSGAASTKHS
DGDSVLQDAG HLTAEQSNNL ALKSESYAAG AVLDLCDDQH RTEPVKCNEI LDHPEQTAAL
DTECVTVAPQ SWSAHSPKDE KACEKLPFTP QDDSARSAAS TEVCGGNAIG KVDPNHESNA
DSMPSDLPKR HLLHSSNAAS PGNGVLPGSS CQIGAEAELE KRGAEDNVDS EELNSRERVS
SSEIVSSVSS SCMSAEDVQT SLSCLSLPVS MCGSLVATEE KVNPLPQNAV AEVISDTVAI
HAGEPKAHLP GRESCESTSW REQEDLAEIS ESIAEKGSDG EKYSTENVTD DGDSQQIKGF
ASAFLDLGAE PYSVGVDTFY DESMSSVMAD FTVEENVIKS DILISDAELD DFLYGQSLQS
SVLKSSDSDG NLMEADADGG DLTDLNNLVF TEISEELVQT KLEEITSINS NLKASVPDNE
VEAAAKVSMS HGQGVTESGS GALASDVCIK GARPKQLLDL SQGAAGQKQL NRTSEPEREN
QESGSVTAEA PLSGISVNAG NNYDPGESSC EAGGNQTSES AESRRTPPAL SWKQPLWVPD
SEAPNCMNCQ AKFTFTKRRH HCRACGKVFC GSCCKRKCKL QYMEKEARVC TGCYDDINKA
QAFERMMSPT GPVPNSSVSS EHSSAVPPVE EGQVPAGASS PSPSALLPTS ALKQPGPEGL
CPREQKRVWF ADGILPNGEV ADTAKLSSGA KRSQDCSPVT PELPQTPTAA NPEEDDLITD
VNQKLKEEID KIPRMEELHP SVPSDSTQQA TPGQSEVTPG YKSGGEECSP AAAEESSPSS
VEQSTQGVPV TASSYRALCG VENWVPREIS LLPDGDQLPP LLLALGERGK DILVEEHPFH
QKVTLLLGEG GPNPLTFILN ANLLVNVKLI TYSSEKCWCF STNGLHGLGQ AEIVILLQRL
PDEDVFPSEI FKLFLDIYKD AMKGRFIKNM ENITFTENFL SNKEHGGFLF VSPTFQKLDD
QILPDKPFLY GILIHKLEIP WAKVFPIRLM LRLGAEYGAC PTPVVSVRHR KPLFGDIGHT
IMNLLVDLRN YQYTLHTIDN LFVHVEMGRS CIKIPLRRYN EVMRVINSSN EYVISIGASF
NTEADSHLVC VQNKQGLYHT QAISATGQPR KVTGASFVVF NGALKTSSGF LAKSSIVEDG
LMVQITRETM ESLRQALRDK KDFKITCGKM DAGDVKEYVD ICWVENEEKT NQGILSPVDG
KSMEGTQSEK APQYRDFERD GKVMKCTEVY YFVKDHELPG AVAHQFAKEI AIACSTALCP
HLKTLKNNGM NKIGLRVSID SDMVEYLAGS GGYLLPQNYL NDLDSALIPV IHGGMSDPAA
LPLKMELVFF IIEHLL
//
