ID U3KF63_FICAL Unreviewed; 705 AA.
AC U3KF63;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Receptor interacting serine/threonine kinase 1 {ECO:0000313|Ensembl:ENSFALP00000013667.1};
GN Name=RIPK1 {ECO:0000313|Ensembl:ENSFALP00000013667.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000013667.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000013667.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000013667.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005041561.1; XM_005041504.1.
DR AlphaFoldDB; U3KF63; -.
DR STRING; 59894.ENSFALP00000013667; -.
DR Ensembl; ENSFALT00000013723.2; ENSFALP00000013667.1; ENSFALG00000013093.2.
DR GeneID; 101806351; -.
DR KEGG; fab:101806351; -.
DR CTD; 8737; -.
DR eggNOG; KOG0192; Eukaryota.
DR GeneTree; ENSGT00940000159347; -.
DR HOGENOM; CLU_017229_0_0_1; -.
DR OMA; DIIEHCP; -.
DR OrthoDB; 3997405at2759; -.
DR Proteomes; UP000016665; Chromosome 2.
DR GO; GO:0031264; C:death-inducing signaling complex; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0097342; C:ripoptosome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0070513; F:death domain binding; IEA:Ensembl.
DR GO; GO:0005123; F:death receptor binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:1990000; P:amyloid fibril formation; IEA:Ensembl.
DR GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0060546; P:negative regulation of necroptotic process; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1900119; P:positive regulation of execution phase of apoptosis; IEA:Ensembl.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0070105; P:positive regulation of interleukin-6-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; IEA:Ensembl.
DR GO; GO:1903800; P:positive regulation of miRNA processing; IEA:Ensembl.
DR GO; GO:0060545; P:positive regulation of necroptotic process; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR GO; GO:1901026; P:ripoptosome assembly involved in necroptotic process; IEA:Ensembl.
DR GO; GO:0070231; P:T cell apoptotic process; IEA:Ensembl.
DR CDD; cd08777; Death_RIP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR025735; RHIM_dom.
DR InterPro; IPR037934; RIP1_Death.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF983; RECEPTOR INTERACTING SERINE_THREONINE KINASE 1; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF12721; RHIM; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 13..284
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 617..703
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 421..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 80266 MW; 60CDADB395196DE4 CRC64;
MSLEDIHMNT KDLLEKKQLD AGGFGTISLC FHKKHGYVVL KKVYTGPQRT EYNVSLLEEG
RIMRRLQHDR VVKLLGVILE DGNYSLVMEY VDRGNMMKVL QNLSLPLSVK GRFVLEITEG
MLYLHEQGFV HKDLKPENIL VDRDFHIKIA DLGVASFKSW SRLTQEETVR QKQMKSTYQN
NAGTLFYMAP EHLRCVNTKP VEKSDVYSFG IVIWAIFANK EPYENAINES HICFGIINGN
RPDIKEISDK CPVEIIDLMK QCWDEESKKR PTFAEISERY EPFYYQNLGK NIEEDLKNLK
KMWPESNELL HSMESLQIDA VPEDTSNGQI DQPNSLHSSQ GPMTNEVNEA LFTASPENQP
IESCETSFAL PDNLERKLQH EYNYHAFGSR MDKETPPLAQ NFSVEWSPGI IQEKTVKVFS
DPFAKPSPTS QRSEQYPRAE KAASNTNPYF HANTDPNFWS QAAAKTLKWG NADTFYRPSP
NSLPVGNPGD AYGLSSASNF SLSKPPVPES GQNWQPQTNV NWYSKNADTD TGYRDSTSFT
RGTFAYHPST SRGSSVPYTD DSIKYNISNS SGIQIGSYNH MKIEEQNPHA STSPVAMQEI
YADYEARGVF DNTTVLTEKH LNLVREKLAK QWKHCARKLG FSDPEIDEID HDYERDGLKE
KVYQMLLKWV MREGSKGATV GKLAKALFGC QRLDLLGSLM QIQEE
//
