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Database: UniProt
Entry: U3KG58_FICAL
LinkDB: U3KG58_FICAL
Original site: U3KG58_FICAL 
ID   U3KG58_FICAL            Unreviewed;      4972 AA.
AC   U3KG58;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   22-NOV-2017, entry version 30.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSFALP00000014012};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSFALP00000014012};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000014012, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000014012}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N.,
RA   Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K.,
RA   Qvarnstrom A., Uebbing S., Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula
RT   flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000014012}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000014012}.
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DR   EMBL; AGTO01010158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFALT00000014069; ENSFALP00000014012; ENSFALG00000013270.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000016665; Unplaced.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4281   4299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4502   4522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4579   4598       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4715   4736       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4773   4794       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4849   4872       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    217       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      225    280       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      286    343       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      351    408       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      611    809       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1025   1222       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1350   1563       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4024   4059       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4972 AA;  566085 MW;  9FFD8E2BEDE8E9FF CRC64;
     LLLPGQGNRK SIYAVIDDEV VLQCTATVHK EQQKLCLAAE GFGNRLCFLE STSNSKNVPP
     DLSICTFVLE QSLSVRALQE MLANTEEKAE GLVDVEKWKF MMKSAQGGGH RTLLYGHAIL
     LRHSYSGMYL CCLSTSRSSM DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD
     LILVSVSSER YLHLSYGNGS LHVDAAFQQT LWSVAPISSG SEVAQGYLIG GDVLRLLHGH
     MDECLTVPSG EHGEEQRRTV HYEGGAVSIH ARSLWRLETL RVAWSGSHIR WGQPFRLRHI
     TTGKYLSLLD DKSLLLTDKE KADVKSTAFC FRSSKEKLDI GTRKEVDGMG APEIKYGDSI
     CFIQHVDTGL WLTYQSADAK SVRMGSLQRK AIMHHEGHMD DGLTLSRSQN EESRTARVIR
     STVFLFNRFI RGLDSLSKKV KSSTIDLPIE SVSLSLQDLI GYFHPPDEHL EHENKQNRLR
     ALKNRQNLFQ EEGMINLVLE CIDRLNVYSS AAHFADVAGK EAGEAWKSIL NSLYELLAAL
     IRGNRKNCAQ FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIICL
     LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN HVSSMRPNIF
     LGISEGSAQY RKWYYELMVD HLEPFVTAES THLRVGWAST EGYSPYPGGG AEWGGNGVGD
     DLYSYGFDGL HLWSGCVART VNSPNQHLLR TDDVISCCLD LSAPSISFRI NGQPVQGMFE
     NFNIDGLFFP VVSFSAGIKV RFLLGGRHGE FKFLPPPGYA PCFEAVLPKE KLKVEHSREY
     KQDRSYTRDL LGPTVSLSQA AFTPVPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL
     GWQYGPVRDD NKRQHPCLVE FSKLPEQERN YNLQMSLETL KTLLALGCHV GIADERAEEK
     VKKMKLPKNY QLLSGYKPAP MDLSFIKLTP SQEAMVDKLA ENAHNVWARD RIRQGWTYGI
     QQDVKNRRNP RLVPYALLDD RTKKSNKDSL REAVRTLLGY GYNLEAPDQD HATRLDMCSG
     IMEKFRIFRT EKTYAVKAGK WYFEFEAVTA GDMRVGWTRP GCLPDQELGS DEEAFVFDGF
     KAQRWHQGNE HFGRSWLAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFEVADG
     FLPVCSLGPS QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITIW LSKRLPQFLP
     VPQNHEHIEV MRIDGTIDSC PCLKVTQKSF GSQNSKTDVM FFRLSMPIEC AEVFSRSAAG
     GLPGSGLFGP KNDLEDYDAD SDFEVLMKTA HGHLVPDRTE REKDSTKPEL NNHKDYVQEK
     PSRLKQSRFM LRRTKPDYST SHSARLTEDV LADDRDDYDY LMQTSTYYYS VRIFPGQEPA
     NVWVGWITSD FHQYDTSFDL DRVRTVTVTL GDEKGKVHES IKRSNCYMVC AGESLSPGQG
     RNNNGLEIGC LVDAASGLLT FTANGKELGT YYQVEPSTKL FPAVFAQATS PNVFQFELGR
     IKNVMPLSAG LFKSEHKNPV SQCPPRLHVQ FLTHVLWSRV PNHFLKVDVS RISERQGWMI
     QCLNPLQFMA LHIPEENRTI DILELTEQEE LLKFHYHTLR LYSAVCALGN NRVAHALCSH
     VDESQLLYAI ENKYMPGLLR AGYYDLLIDI HLNTYATARL MMNNEFIVPM TDETKSITLF
     PDENKKHGLP GIGLSTSLRP RMQFSSPSFV SISSECFQFS PEFPLEILKA KTIEMLTEAV
     QEGSLHVRDP VGGSTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPR VFKEAMSQED
     EVDFSEKEFS SDEFKSEEGE EETRGEQMPK EGLLQMKLPE PVKLQMCHLL QYLCDCQVRH
     RIEAIVAFSD DFVAKLQENQ RFRYNEVMQA LNMSAALTAR KTKEFRSPPQ EQINMLLNFK
     DDKNDCPCPE EIRDQLLDFH EDLMTHCGIE LDEDGTLDGN SDSTIRGRLL YLMEKVTYLK
     KKQAEKTVDD DDKTSSTLQQ LISDTMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR
     ALPKTYTINS VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN
     LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL CYFCRISRQN QKAMFDHLSY
     LLENSSVGLA SPSMRGSTPL DVAAASVMDN NELALALREP DLEKVVRYLA GCGLQSCPLL
     ICKGYPDIGW NPVEGERYLD FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG
     NGLLAAMEEA IQISEDRTRD GPSPSNGSSK TLEIEEQEDD TIHMGNAIMT FYAALIDLLG
     RCAPEMHLIH AGKGEAIRIR SILRSLIPLE DLVGVISIAF HMPTIAKDGT VVEPDMSAGF
     CPDHKAAMVL FLDRVYGIED QDFLLHLLEV GFLPDLRAAA SLDTAALSAT DMALALNRYL
     CTAVLPLLTR CAPLFAGTEH HASLIDSLLH TVYRLSKGCS LTKAQRDSIE ECLLSICGQL
     RPSMMQHLLR RLVFDVPLLN EHAKMPLKLL TNHYERCWKY YCLPSGWGNF GAASEEELHL
     SRKLFWGIFD ALSQKKYEQE LFKLALPCLS AVAGALPPDY MESNYVNMME KQSSMDSDGN
     FNPQPVDTSN ITIPEKLEYF INKYAEHAHD KWSMEKFANG WTYGETFSES AKVQPLMKQY
     KLLSEKEKEI YRWPIKESLK TMLAWGWRIE RTREGDSMAL YNRTRRISQT SQISVDTAHG
     YTPRAIDMSN VTLSRDLHAM AEMMAENYHN IWAKKKKLEL EAKVGGGNHP LLVPYDTLTA
     KEKAKDREKA QDILKFLQIN GYVVSRGLKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY
     ILEFDGGSRG KGEQFPYEQE IKFFAKVVLP LIDQYFKNHR LYFLSSASRP LSSGGHASNK
     EKEMVTSLFC KLGVLVRHRI SLFGNDATSI VNCLHILGQT LDARTVMKTG LESVRMALRA
     FLDNAAEDLE KTMENLKQGQ FTHSRNQPKG VTQIINYTTV ALLPVLSSLF EHIGQHQFGE
     DLILEDVQVS CYRILASLYA LGTSKSIYVE RQRSALGECL AAFSGAFPVA FLETHLNKHN
     IYSIYNTKNA RDRAVLNLPT SVEEVCPNIP SLVKLMEEIV ELAESGIRYT QMPHIMEVIL
     PMLCSYMSHW WEHGPENNPD RAEMCCTALT SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL
     AVFSQPIISK AKPQLLKTHF LPLMDKLKKK AAVVVSDEEH LRAEGRGDMS EAELLILDEF
     TTLARDLYAF YPLLIRFVDY NRAKWLKEPN PEAEELFRMV AEVFIYWSKS HNFKREEQNF
     VVQNEINNMS FLISDTKSKM SKAAVSDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN
     ICAPGDQELI ALAKNRFSMK DTEDEVRDVI RSNLHLQGKL EDPAIRWQMA LYKDLPNRTE
     DSSDPEKTVE RVLDIANVLF HLEQKSACVG RGYFFWVEHP QRSKKAVWHK LLSKQRKRAV
     VACFRMAPLY NLPRHRAVNL FLQGYDKSWI ETEEHYFEDK LIEDLAKPGE EPPEEDESLK
     RVDPLHQLIL LFSRTALTEK CKLEEDFLYM AYADIMAKSC HDEEDDDGEE EVKSFEEKEM
     EKQKLLYQQA RLHDRGAAEM VLQTISASKG EMGPMVAATL KLGIAILNGG NSTVQQKMLD
     YLKDKKDVGF FQSLAGLMQS CSVLDLNAFE RQNKAEGLGM VTEEGSGEKV MQDDEFTCDL
     FRFLQLLCEG HNSDFQNYLR TQTGNNTTVN IIISTVDYLL RVQESISDFY WYYSGKDVID
     EQGQRNFSKA IQVAKQVFNT LTEYIQGPCT GNQQSLAHSR LWDAVVGFLH VFAHMQMKLS
     QDSSQIELLK ELMDLQKDMV VMLLSMLEGN VVNGTIGKQM VDMLVESSNN VEMILKFFDM
     FLKLKDLTSS DAFKEYDPDG KGIISKRDFH RAMESHKHYT QSETEFLLSC AETDENETLD
     YEEFVKRFHE PAKDIGFNVA VLLTNLSEHM PHDTRLQTFL ELSESVLNYF QPFLGRIEIM
     GSAKRIERVY FEISESSRTQ WEKPQVKESK RQFIFDVVNE GGEKEKMELF VNFCEDTIFE
     MQLAAQISES DLNERSANKE ENEKDNPEEE DPRMGFFSLV TMKSALVALK YNLMTLMKML
     SMKSLKKQMK KVKKMTMKDM VMALFSSYWS ILMGLLHFAC SVVRGFFRII CSLLLGGSLV
     EGAKKIKVAE LLANMPDPTQ DEVRGEEEEG ERKPTEAALP AEDLTDLQTL TEESDLLSDI
     FGLDLKREGG QYKLIPHNPN AGLSDLLSTP SLAPMPEVQE KIQEKVKEDE KEEKEETKSE
     PEKAEGEDGE KEEKTKEDKG KQKLRQLHTH RYGEPEVQES VFWKNIIAYQ QKLLNYFARN
     FYNMRMLALF VAFAINFILL FYKVSTSAVT EEKELPVVSD GESTKLNILE SDDDDDERVI
     AVHYVLEESS GYMEPTLRIL AILHTVISFF CIIGYYCLKV PLVIFKREKE VARKLEFDGL
     YITEQPSEDD IKGQWDRLVI NTQSFPNNYW DKFVKRKVMD KYGEFYGRDR ISELLGMDKA
     ALDFSDAREK KKPKKDSSFS AVLNSIDVKY QMWKLGVVFT DNSFLYLAWY MTMSVLGHYN
     NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK
     SEDGDMPDMK CDDMLTCYMF HMYVGVRAGG GIGDEIEDPA GDEYEIYRII FDITFFFFVI
     VILLAIIQGL IIDAFGELRD QQEQVKEDME TKCFICGIGN DYFDTVPHGF ETHTLQEHNL
     ANYLFFLMYL INKDETEHTG QESYVWKMYQ ERCWEFFPAG DCFRKQYEDQ LN
//
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