ID U3KML0_RABIT Unreviewed; 880 AA.
AC U3KML0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 2 {ECO:0000256|ARBA:ARBA00020977};
DE AltName: Full=Component of oligomeric Golgi complex 2 {ECO:0000256|ARBA:ARBA00031344};
GN Name=COG2 {ECO:0000313|Ensembl:ENSOCUP00000026469.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026469.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026469.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000026469.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026469.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026469.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the COG2 family.
CC {ECO:0000256|ARBA:ARBA00007603}.
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DR EMBL; AAGW02026188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; U3KML0; -.
DR Ensembl; ENSOCUT00000033422.2; ENSOCUP00000026469.2; ENSOCUG00000000472.4.
DR GeneTree; ENSGT00390000012040; -.
DR HOGENOM; CLU_005470_0_0_1; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000000472; Expressed in liver and 17 other cell types or tissues.
DR ExpressionAtlas; U3KML0; baseline.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007030; P:Golgi organization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR009316; COG2.
DR InterPro; IPR024603; COG_complex_COG2_C.
DR InterPro; IPR024602; COG_su2_N.
DR PANTHER; PTHR12961; CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2; 1.
DR PANTHER; PTHR12961:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2; 1.
DR Pfam; PF06148; COG2; 1.
DR Pfam; PF12022; COG2_C; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 190..322
FT /note="Conserved oligomeric Golgi complex subunit 2 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF06148"
FT DOMAIN 553..874
FT /note="COG complex component COG2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12022"
FT REGION 74..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 98492 MW; 30DEF3CF70ED339F CRC64;
MRLRGCDPLG MRARVPGGRQ SALATALCIT KRSNLKAEDT VRALQDLSQW KRWGREGAQL
APLPHPSRAQ LSLPGNWPNG SPQDPAVPLS DARGQHVQDS PAAAFREPLL AAARRRPARG
ALAHWLQRGR CHVGGSGASC AVETVRGGGL RVRLRSLLSL RLARVSVLRD GGLRIMEKSR
MNLPKGPDTL CFDKDEFLKE DFDVDHFVSD CRKRVQLEEL RDDLELYYKL LKTAMVELIN
KDYADFVNLS TNLVGMDKAL NQLSVPLGQL REEVLSLRSS VSEGIRAVDE RMSKQEDIRK
KKMCVLRLIQ VIRSVEKIEK ILNSQNSKET SALEASSPLL TGQILERIAT EFNQLQFHAV
QSKGMPLLDK IRPRIAGITA MLQQSLEGLL LEGLQTSNVD IVRHCLRTYA TIDKTRDAEA
LVGQVLVKPY IDEVIVEHFV ESHPSGLQMM YDKLLEFVPH HCRLLREVTG GAISSEKGNI
VPGYDFLVNS LWPEIVQGLE EKLPSLFNPG NPDAFHEKYT ISMDFLRRFE EQCGSQASVK
RLRAHPAYHS FNNKWNLPVY FQIRFREIAG SLEAALTDVL EDAPAGSPYC LLASHRTWSS
LRKCWSDELF LPLLVHRLWR LTLQILARYS VFVSELSLRP ISNETAKESK KPLITGSRDP
STSPGNSEDP GSSAADTKPV VSISSTQLIY VVADLHTLQE QLPELLEIIK PKLEMIGFSN
FSSISAALED SQSSLSACIP PLSSKIIQDL SESCFRYLKS ALEVPRLYRR TNKEVPTAAS
SYVDSALKPF HQLQRGHKDK LKHAVIQQWL EGALSESTHK YYETVSDVLN SVRKMEESLK
RLKQARKTTP TTPVGPSGGM SDDDKIRLQL ALDVEYLGEQ
//
