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Database: UniProt
Entry: U3KNJ5_RABIT
LinkDB: U3KNJ5_RABIT
Original site: U3KNJ5_RABIT 
ID   U3KNJ5_RABIT            Unreviewed;      1867 AA.
AC   U3KNJ5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   30-AUG-2017, entry version 27.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSOCUP00000026804};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026804, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000026804, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000026804}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026804};
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000026804}.
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DR   EMBL; AAGW02004230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02004231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02004232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOCUT00000033757; ENSOCUP00000026804; ENSOCUG00000007266.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000001811; Chromosome 7.
DR   Bgee; ENSOCUG00000007266; -.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1867       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5004646488.
FT   TRANSMEM    119    139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    268    295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    627    645       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    657    675       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    737    765       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    824    850       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1077   1095       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1135       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1191   1219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1317   1341       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1400   1418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1430   1448       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1460   1480       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1517   1545       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1621   1644       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    302       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      374    576       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      627    854       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      864   1071       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1075   1349       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1399   1654       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      292    337       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1867 AA;  212821 MW;  811033843B15B12D CRC64;
     MLIMCTILTN CVFMTMSNPP DWTKNVEYTF TGIYTFESLI KIIARGFCLE DFTFLRDPWN
     WLDFTVITFA YVTEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM
     ILTVFCLSVF ALIGLQLFMG NLRNKCIQWP PTNASLEEHS IEKNITVDNN GTIVNETVFE
     FDWKSYIQDT RYHYFLEGVL DALLCGNSSD AGQCPEGYMC VKAGRNPNYG YTSFDTFSWA
     FLSLFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFLGS FYLINLILAV VAMAYEEQNQ
     ATLEEAEQKE AEFQQMLEQL KKQQEAAQQA AATTASEHSR EPSAAGRLSD SSSEASKLSS
     KSAKERRNRR KKRKQKEQSG GEEKDEDEFQ KSESEDSIRR KGFRFSIEGN RLTYEKRYSS
     PHQSLLSIRG SLFSPRRNSR TSLFSFRGRA KDVGSENDFA DDEHSTFEDN ESRRDSLFVP
     RRHGERRNSN LSQTSRSSRM LAVFPANGKM HSSVDCNGVV SLVGGPSVPT SPVGQLLPEG
     TTTETEMRKR RSSSFHVSMD FLEDPSQRQR AMSIASILTN TVEELEESRQ KCPPCWYKFS
     NIFLIWDCSP YWLKVKHIVN LVVMDPFVDL AITICIVLNT LFMAMEHYPM TEHFNNVLAV
     GNLVFTGIFT AEMFLKIIAM DPYYYFQEGW NIFDGFIVTL SLVELGLANV EGLSVLRSFR
     LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKSYKDCVCK
     IASDCKLPRW HMNDFFHSFL IVFRVLCGEW IETMWDCMEV AGQAMCLTVF MMVMVIGNLV
     VLNLFLALLL SSFSADNLAA TDDDNEMNNL QIAVDRMHKG IAYVKRKIYE FIQQSFVRKQ
     KILDEIKPLD DLNNKKDSCM SNHTAEIGKD LDYLKDVNGT TSGIGTGSSV EKYIIDESDY
     MSFINNPSLT VTVPIAVGES DFENLNTEDF SSESDLEESK EKLNESSSSS EGSTVDIGAP
     AEEQPVVEPE ETLEPEACFT EGCVQRFKCC QISVEEGRGK QWWNLRRTCF RIVEHNWFET
     FIVFMILLSS GALAFEDIYI DQRKTIKTML EYADKVFTYI FILEMLLKWV AYGYQTYFTN
     AWCWLDFLIV DVSLVSLTAN ALGYSELGAI KSLRTLRALR PLRALSRFEG MRVVVNALLG
     AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK FYHCINTTTG DMFEITEVNN HSDCLKLIER
     NETARWKNVK VNFDNVGFGY LSLLQVATFK GWMDIMYAAV DSRNVELQPK YEESLYMYLY
     FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK FGGQDIFMTE EQKKYYNAMK KLGSKKPQKP
     IPRPGNKFQG MVFDFVTRQV FDISIMILIC LNMVTMMVET DDQSDYVTNI LSRINLVFIV
     LFTGECVLKL ISLRHYYFTI GWNIFDFVVV ILSIVGMFLA ELIEKYFVSP TLFRVIRLAR
     IGRILRLIKG AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IYAIFGMSNF AYVKREVGID
     DMFNFETFGN SMICLFQITT SAGWDGLLAP ILNSKPPDCD PNKVNPGSSV KGDCGNPSVG
     IFFFVSYIII SFLVVVNMYI AVILENFSVA TEESAEPLSE DDFEMFYEVW EKFDPDATQF
     MEFEKLSQFA AALEPPLNLP QPNKLQLIAM DLPMVSGDRI HCLDILFAFT KRVLGESGEM
     DALRIQMEER FMASNPSKVS YQPITTTLKR KQEEVSAVII QRAYRRHLLK RTVKQASFTY
     NKNKIKSGAN LLVKEDMIID RINENSITEK TDLTMSTAAC PPSYDRVTKP IVEKHEQEGK
     DEKAKGK
//
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