ID U3LG48_9SAUR Unreviewed; 221 AA.
AC U3LG48;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT3 {ECO:0000313|EMBL:AFW21071.1};
OS Agama lionotus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Acrodonta; Agamidae; Agaminae; Agama.
OX NCBI_TaxID=662664 {ECO:0000313|EMBL:AFW21071.1};
RN [1] {ECO:0000313|EMBL:AFW21071.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24973715; DOI=10.1016/j.ympev.2014.06.013;
RA Leache A.D., Wagner P., Linkem C.W., Bohme W., Papenfuss T.J., Chong R.A.,
RA Lavin B.R., Bauer A.M., Nielsen S.V., Greenbaum E., Rodel M.O., Schmitz A.,
RA LeBreton M., Ineich I., Chirio L., Ofori-Boateng C., Eniang E.A.,
RA Baha El Din S., Lemmon A.R., Burbrink F.T.;
RT "A hybrid phylogenetic-phylogenomic approach for species tree estimation in
RT African Agama lizards with applications to biogeography, character
RT evolution, and diversification.";
RL Mol. Phylogenet. Evol. 79:215-230(2014).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; JX839221; AFW21071.1; -; Genomic_DNA.
DR AlphaFoldDB; U3LG48; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 136..221
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFW21071.1"
FT NON_TER 221
FT /evidence="ECO:0000313|EMBL:AFW21071.1"
SQ SEQUENCE 221 AA; 24928 MW; 960B58BB298BCB7C CRC64;
FAYLRGIQST NMDQGSLQEE SINSLIIKLI QADILKNKAS KQMVDIKDGV QSTVKKTGAT
EAEVDGSSRM KLDSQLVISM DTEFLRQQRR YSSPRVLLSD NTPLEPPPLY LMEDYIGSAV
VVNRTSRRKR FAENKSHRGE YSVCDSESRW VTDKVSAIDI RGHQVTVLGE IKMGPSPVKQ
YFYETRCKQA KPAKSGCRGI DDKHWNSQCK TSQTFVRALT S
//
