ID U3N9W9_ACIBA Unreviewed; 185 AA.
AC U3N9W9;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Helix-turn-helix domain-containing protein {ECO:0000313|EMBL:MVM93034.1};
DE SubName: Full=Recombinase family protein {ECO:0000313|EMBL:AYY87349.1};
DE SubName: Full=Resolvase {ECO:0000313|EMBL:AIL25519.1, ECO:0000313|EMBL:AKT74064.1};
DE SubName: Full=TnpR {ECO:0000313|EMBL:AGW28874.1};
GN Name=tnpR {ECO:0000313|EMBL:AGW28874.1};
GN ORFNames=EGM95_00440 {ECO:0000313|EMBL:AYY87349.1}, EGM95_08090
GN {ECO:0000313|EMBL:AYY88729.1}, EGM95_09430
GN {ECO:0000313|EMBL:AYY88976.1}, GNY86_15995
GN {ECO:0000313|EMBL:MVM93034.1};
OS Acinetobacter baumannii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=470 {ECO:0000313|EMBL:AGW28874.1};
RN [1] {ECO:0000313|EMBL:AGW28874.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM98 {ECO:0000313|EMBL:AGW28874.1};
RX PubMed=24080502; DOI=10.1093/jac/dkt379;
RA Hamidian M., Wynn M., Holt K.E., Pickard D., Dougan G., Hall R.M.;
RT "Identification of a marker for two lineages within the GC1 clone of
RT Acinetobacter baumannii.";
RL J. Antimicrob. Chemother. 69:557-558(2014).
RN [2] {ECO:0000313|EMBL:AHL30825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A85 {ECO:0000313|EMBL:AHL30825.1};
RX PubMed=24907141; DOI=10.1093/jac/dku188;
RA Hamidian M., Kenyon J.J., Holt K.E., Pickard D., Hall R.M.;
RT "A conjugative plasmid carrying the carbapenem resistance gene blaOXA-23 in
RT AbaR4 in an extensively resistant GC1 Acinetobacter baumannii isolate.";
RL J. Antimicrob. Chemother. 69:2625-2628(2014).
RN [3] {ECO:0000313|EMBL:AIL25519.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M3AC9-7 {ECO:0000313|EMBL:AIL25519.1};
RX PubMed=25246647;
RA Martinez T., Vazquez G.J., Aquino E.E., Martinez I., Robledo I.E.;
RT "ISEcp1-Mediated Transposition of blaKPC into the Chromosome of a Clinical
RT Isolate of Acinetobacter baumannii from Puerto Rico.";
RL J. Med. Microbiol. 0:0-0(2014).
RN [4] {ECO:0000313|EMBL:AIL25519.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M3AC9-7 {ECO:0000313|EMBL:AIL25519.1};
RA Teresa M., Robledo I.E., Vazquez G.J., Aquino E.E., Martinez I.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AIZ49365.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A297 {ECO:0000313|EMBL:AIZ49365.1};
RA Hamidian M., Holt K., Pickard D., Dougan G., Hall R.;
RT "Acinetobacter baumannii strain A297 (RUH875) multiple antibiotic
RT resistance region AbaR21.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AGW28874.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM98 {ECO:0000313|EMBL:AGW28874.1};
RA Holt K.E., Kenyon J.J., Hamidian M., Schultz M.B., Pickard D.J., Dougan G.,
RA Hall R.M.;
RT "Evolutionary history of Acinetobacter baumannii Global Clone 1 reveals the
RT emergence of diverse subclones with distinct surface polysaccharides and
RT antimicrobial resistance genotypes.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AKT74064.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A320 {ECO:0000313|EMBL:AKT74064.1};
RA Blackwell G.A., Holt K.E., Pickard D., Hall R.M.;
RT "AbGRI2-0, the progenitor of AbGRI2 resistance island in global clone 2 of
RT Acinetobacter baumannii.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AYY87349.1, ECO:0000313|Proteomes:UP000273577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN15313 {ECO:0000313|EMBL:AYY87349.1,
RC ECO:0000313|Proteomes:UP000273577};
RA Sorenson N.M., Snesrud E., Xavier D.E., Cacci L.C., Oeleman W.,
RA Iavarone A.T., Mc Gann P., Riley L.W., Moreira B.M.;
RT "A novel plasmid carries a functional mcr-4.3 gene in a colistin-resistant
RT Acinetobacter baumannii clinical strain.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:MVM93034.1, ECO:0000313|Proteomes:UP000439424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac576 {ECO:0000313|EMBL:MVM93034.1,
RC ECO:0000313|Proteomes:UP000439424};
RA Fedrigo N.H., Cerdeira L., Fuga B., Marini P.V.B., Shinohara D.R.,
RA Carrara-Marroni F.E., Lincopan N., Tognim M.C.B.;
RT "Multidrug-resistant Acinetobacter baumannii moving toward extensively
RT drug-resistant over fifteen years in South of Brazil.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC {ECO:0000256|ARBA:ARBA00009913}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KF483599; AGW28874.1; -; Genomic_DNA.
DR EMBL; KC118540; AHL30825.1; -; Genomic_DNA.
DR EMBL; KJ748372; AIL25519.1; -; Genomic_DNA.
DR EMBL; KM921776; AIZ49365.1; -; Genomic_DNA.
DR EMBL; JN247441; AKT74064.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY87349.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY88729.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY88976.1; -; Genomic_DNA.
DR EMBL; WPIP01000152; MVM93034.1; -; Genomic_DNA.
DR RefSeq; WP_001217881.1; NZ_WTZO01000013.1.
DR OMA; EQIRFAY; -.
DR Proteomes; UP000273577; Chromosome.
DR Proteomes; UP000439424; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR CDD; cd03768; SR_ResInv; 1.
DR Gene3D; 6.10.250.10; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006118; Recombinase_CS.
DR InterPro; IPR006119; Resolv_N.
DR InterPro; IPR036162; Resolvase-like_N_sf.
DR InterPro; IPR006120; Resolvase_HTH_dom.
DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1.
DR PANTHER; PTHR30461:SF22; SERINE RECOMBINASE PINE-RELATED; 1.
DR Pfam; PF02796; HTH_7; 1.
DR Pfam; PF00239; Resolvase; 1.
DR SMART; SM00857; Resolvase; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF53041; Resolvase-like; 1.
DR PROSITE; PS00397; RECOMBINASES_1; 1.
DR PROSITE; PS00398; RECOMBINASES_2; 1.
DR PROSITE; PS51736; RECOMBINASES_3; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 2..137
FT /note="Resolvase/invertase-type recombinase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51736"
FT ACT_SITE 10
FT /note="O-(5'-phospho-DNA)-serine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606118-50,
FT ECO:0000256|PROSITE-ProRule:PRU10137"
SQ SEQUENCE 185 AA; 20618 MW; A160E3DBFAF59C00 CRC64;
MRIFGYARVS TSQQSLDIQI RALKDAGVKA NRIFTDKASG SSTDREGLDL LRMKVEEGDV
ILVKKLDRLG RDTADMIQLI KEFDAQGVAV RFIDDGISTD GDMGQMVVTI LSAVAQAERR
RILERTNEGR QEAKLKGIKF GRRRTVDRNV VLTLHQKGTG ATEIAHQLSI ARSTVYKILE
DERAS
//
