ID U3PIL0_CTEID Unreviewed; 250 AA.
AC U3PIL0;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tumor necrosis factor superfamily member 12 {ECO:0000313|EMBL:AGW47747.1};
GN Name=TWEAK {ECO:0000313|EMBL:AGW47747.1};
OS Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX NCBI_TaxID=7959 {ECO:0000313|EMBL:AGW47747.1};
RN [1] {ECO:0000313|EMBL:AGW47747.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25501222; DOI=10.4238/2014.December.4.5;
RA Pandit N.P., Shen Y.B., Chen Y., Wang W.J., Li J.L.;
RT "Molecular characterization, expression, and immunological response
RT analysis of the TWEAK and APRIL genes in grass carp, Ctenopharyngodon
RT idella.";
RL Genet. Mol. Res. 13:10105-10120(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; KF267443; AGW47747.1; -; mRNA.
DR AlphaFoldDB; U3PIL0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR PANTHER; PTHR15151:SF27; TUMOR NECROSIS FACTOR SUPERFAMILY MEMBER 12; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 111..249
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 250 AA; 28663 MW; 3F8DBF895E5ED8B9 CRC64;
MWKLQNGKRP VCATMQRFFQ RKRIRTLRLV WSLMAALALS LAVCSAIFTV WTLRQTRDLS
RSFQTLQERL EQVNMQRKAI FQLILEKREL LESQRFRRDV GGRKGNGRKV ASHFEITNNS
FQKVGNEGVI KGWTEEQLNM SRAVHYNPET GTFKVERAGV YFLYCQVHFN ENQSQYVKLE
VSVSKGPSLQ CIEGYGTTPA SGSHKFHFLK PCQVSGLLRL NKGAELKAVT GSSFSLQMSG
KHYFGLFKVN
//
