ID U4LFI0_PYROM Unreviewed; 904 AA.
AC U4LFI0;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Similar to Uncharacterized protein C354.08c acc. no. O43022 {ECO:0000313|EMBL:CCX14179.1};
GN ORFNames=PCON_13772 {ECO:0000313|EMBL:CCX14179.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX14179.1};
RN [1] {ECO:0000313|EMBL:CCX14179.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX14179.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX14179.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; HF935909; CCX14179.1; -; Genomic_DNA.
DR AlphaFoldDB; U4LFI0; -.
DR STRING; 1076935.U4LFI0; -.
DR eggNOG; KOG1134; Eukaryota.
DR OMA; GKGFFAW; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..201
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 224..393
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 451..664
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 861..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 103253 MW; 87ECC8F4917CF02B CRC64;
MAEGSCQVTT GLSLMRRQMT GKETLDNFLR LVQSPFKQQF TTDAFLASLG TSIGVSTIIF
LIWCTLRPYH QLVYAPKLRH ADEKHAPPMI GKGYFSWFAP LIKCKEDDLV EKIGMDATVF
LRFIRLCRNL FFWLGLLGVI VIIPVNVTCN IKNTTKDPNW KPNKSWYILM SPSYTWGTCM
WAHVIIAWVF DFIIMFFLWK NYRAVLKLKR AYFESPEFID SLHARTLMIW NVPGSYRSDG
GLNKIVSMLK LRQSLDSNEK YAIGRNVKEL PSLMEKHERA VRKLEGVLAK YLKNPDKLPA
ARPLSKPDKD DPQVDQETKV DAIEYWKHRI EELEKKIAIV RKSIDLKDAM PYGFVSFPTI
SRAHITAKAA KGKHPKGTSL QLATKPQDII WDNLVRSKSS RRWKAFIGNL FFIGLSIFFI
IPNALIAVFL SNLNNIALIW PQFQTHLARH PQFFAIVQAW QGDITKSSRE RHVTHKLYVF
FILNNLVIFT LFGTLWSTIR QFVQVAEGNG VNWQTIRNLR FGDNAAVAIF DVSTFWITYL
LQRNLGAILD LCQVVSLVVK SFSVRFLAPT PRQKIEWTAP AAFDYSTYYN YFLFYTTVAL
TFSTVQPLVL PVAFFYFLID SFFKKYSLMY IFVTKVESGG TFWRLIFNRL LFAAGFFNCV
VALIVWVRFN GSTACAVLPL IPILVIFKIY CHKKFDMDLR YYTRGSDRDS ILSAETFNQA
DRLAKRYNHP ALHRKLMKPM ISGKLEHLLP TLYGSRDAPT RGAISLDPLS HTHKKLPTAG
FEIVQEEDMD FANFKNRAEF GADHGAGGLY GDDYSISGAM TPPVGFASPA NSRPASPNPG
AMMHGGYRGV EYYPVAPRSP GLRNSSGGFP FGGIHDDSRS ETESVQHLLR EQSNDTGYDR
YRHR
//
