ID U4PBN7_CAEEL Unreviewed; 262 AA.
AC U4PBN7;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN Name=hxk-3 {ECO:0000313|EMBL:CDH93279.1,
GN ECO:0000313|WormBase:Y77E11A.1b};
GN ORFNames=CELE_Y77E11A.1 {ECO:0000313|EMBL:CDH93279.1}, Y77E11A.1
GN {ECO:0000313|WormBase:Y77E11A.1b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CDH93279.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CDH93279.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CDH93279.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|RuleBase:RU362007}.
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DR EMBL; BX284604; CDH93279.1; -; Genomic_DNA.
DR RefSeq; NP_001294488.1; NM_001307559.1.
DR AlphaFoldDB; U4PBN7; -.
DR SMR; U4PBN7; -.
DR PeptideAtlas; U4PBN7; -.
DR EnsemblMetazoa; Y77E11A.1b.1; Y77E11A.1b.1; WBGene00022306.
DR GeneID; 176958; -.
DR AGR; WB:WBGene00022306; -.
DR WormBase; Y77E11A.1b; CE48834; WBGene00022306; hxk-3.
DR HOGENOM; CLU_014393_5_3_1; -.
DR OrthoDB; 5481886at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00022306; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; U4PBN7; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0046835; P:carbohydrate phosphorylation; IBA:GO_Central.
DR GO; GO:0051156; P:glucose 6-phosphate metabolic process; IBA:GO_Central.
DR GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central.
DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IBA:GO_Central.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF32; PHOSPHOTRANSFERASE; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362007};
KW Proteomics identification {ECO:0007829|EPD:U4PBN7,
KW ECO:0007829|PeptideAtlas:U4PBN7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transferase {ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 21..256
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 262 AA; 28978 MW; ACFBF660C9F5CA81 CRC64;
MNDTVGQLAA AAHKYGPECT IGVVIGYGCN SSYLEKTSRI TKFDAKARGY DHDNMIVVTE
WEEFGKHGEL DDILTQFDRE VDAASVHKGK QLIDKLCGAL YIGEVVRRVL SQLVLDRVLF
EGQSCEKLDE DESFPTKYIS EILGEEEGVF KACRRICEEL EVEMHGTGDY IIIREVCDVI
SRRGASIVAA AISALLRHLE LSSVKIGVGG ALIQFHPTYH QMLKEKLEEL TPITMKFELV
PADEGSCQGA ALIAAVAERL KL
//