ID U4PC90_CAEEL Unreviewed; 1174 AA.
AC U4PC90;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Sema domain-containing protein {ECO:0000313|EMBL:CDH93356.1};
GN Name=plx-1 {ECO:0000313|EMBL:CDH93356.1,
GN ECO:0000313|WormBase:Y55F3AL.1e};
GN ORFNames=CELE_Y55F3AL.1 {ECO:0000313|EMBL:CDH93356.1}, Y55F3AL.1
GN {ECO:0000313|WormBase:Y55F3AL.1e};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CDH93356.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CDH93356.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CDH93356.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CDH93356.1; -; Genomic_DNA.
DR RefSeq; NP_001294557.1; NM_001307628.1.
DR AlphaFoldDB; U4PC90; -.
DR SMR; U4PC90; -.
DR PeptideAtlas; U4PC90; -.
DR EnsemblMetazoa; Y55F3AL.1e.1; Y55F3AL.1e.1; WBGene00004047.
DR GeneID; 246019; -.
DR AGR; WB:WBGene00004047; -.
DR WormBase; Y55F3AL.1e; CE48755; WBGene00004047; plx-1.
DR HOGENOM; CLU_001436_2_0_1; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004047; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; U4PC90; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0002116; C:semaphorin receptor complex; IBA:GO_Central.
DR GO; GO:0017154; F:semaphorin receptor activity; IBA:GO_Central.
DR GO; GO:0008045; P:motor neuron axon guidance; IBA:GO_Central.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IBA:GO_Central.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IBA:GO_Central.
DR GO; GO:0097374; P:sensory neuron axon guidance; IBA:GO_Central.
DR CDD; cd00603; IPT_PCSR; 2.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 3.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:U4PC90,
KW ECO:0007829|PeptideAtlas:U4PC90};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 487..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..105
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 106..201
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 202..288
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 290..381
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 389..492
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
SQ SEQUENCE 1174 AA; 131138 MW; 0C1F842F1897E2F4 CRC64;
MLFEPYGTSL LGSGSTPYGF NVIWSATGFA VGKKSINRVL DNVASLAIDV YSCENLATNC
GRCLTLDADK YDCGWCSLDS KCARPHQCSN RQIPENWLNA SQLCPNPVIE DFKPKKGSIF
GGTRVTINGI NLGRHVSDVE KAVQIANVPC EVVEYVPSQK IVCVTGKSPI KGSNERGVVA
VTLRHDSLKF FAHSTEHFSY VQPVVSSMKP VKGPRSGGTD VTLTGVDLDT GAEVTVRFGQ
IGCKILERAS GWLRCRMGAS GEGGQFPLHI AFDGQLQNLP IPIYFEFTSD PSVQSISPNK
TIPSGGITVD VYGQGFTLLQ RPRMVFTGLG DEKSYGPACS IEDDQMMKCA TPTAPGKDSD
RGSQERITEY AFDFDGAELY RSRIKVMPSP TFETLSEPRF VRPGEDFLTL NGNHLNLAAS
ERDIDVKVGG EPCPLTALAN KVLTCQPPVK KPRGAGKLNP EIVVTVGNAS FSIGEVSYDS
PGLSSSLFFI IMFFIIFMIA LIICLIVLYR RKSNTHQRQM KYLKTQMDTI EMKVATECKE
AFAELQTSLN QYTADLPLGT PTAPFLEYKD YCARVLFPNA GKNHAVLKNL EVDTHKAEAI
EAGLREFHKL LMNKTFLLTM VRTMEANKYF VGKDRVYVGS LLMVVLQEKM GYCTEMLKQL
LRELIEKTVE KKFQPKILFR RSESIAERML AAWFTFLLHD HLKTYDAGKK LYELFWGIKQ
QMEKGPQDAL TLEARYSLSE EKLLRATFEY KELMVFVSAS DSVYSSTQDI PVRVLDCDTI
TQVKEKCLDA KYRGYRFADR PAPGDMELEW KTGMNGKMAL QDIDSSSRVE GGNWKRLNTL
AHYNVPNNAI LTLTSKSNSL YNLSILSDRS EKSSVSMKTP GVGSPKPWGA PPSVIADHAS
SSADTDNGFK LYHLVKPTEH GPTDSQEKMV TEIYLTRLLM MKGTLAKFIT SLLESIFSSS
TVPPCIKYMF DFMDEQAREH GINDPEVVHA WKSNALPLRF WVNLIKNPHF LFDIQKPTKI
EGCLSVVAQT LMDACSTQDH QLTKDSPSSK LLFAKDMYQY RDLVDSYYTE ISMTPRIDDA
TMGANLSAES RQHNGEFHVF SALNELYKYL DQYKESIIDA LESNEHAQAS RLPGRLQDLL
ALMESDYYRA TDYESSTLGL GYNSNSRLMP RDRL
//
