ID U4QTJ4_9BACT Unreviewed; 903 AA.
AC U4QTJ4;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=NADH dehydrogenase (Quinone), chain G {ECO:0000313|EMBL:EIJ77408.1};
GN ORFNames=C75L2_00720061 {ECO:0000313|EMBL:EIJ77408.1};
OS Leptospirillum sp. Group II 'C75'.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Leptospirillum.
OX NCBI_TaxID=1159328 {ECO:0000313|EMBL:EIJ77408.1, ECO:0000313|Proteomes:UP000016760};
RN [1] {ECO:0000313|EMBL:EIJ77408.1, ECO:0000313|Proteomes:UP000016760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22539719; DOI=10.1126/science.1218389;
RA Denef V.J., Banfield J.F.;
RT "In situ evolutionary rate measurements show ecological success of recently
RT emerged bacterial hybrids.";
RL Science 336:462-466(2012).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; JH660548; EIJ77408.1; -; Genomic_DNA.
DR AlphaFoldDB; U4QTJ4; -.
DR HOGENOM; CLU_000422_4_0_0; -.
DR Proteomes; UP000016760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR000283; NADH_UbQ_OxRdtase_75kDa_su_CS.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR PIRSF; PIRSF036643; FDH_alpha; 2.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00641; COMPLEX1_75K_1; 1.
DR PROSITE; PS00642; COMPLEX1_75K_2; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 2..78
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 78..117
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 137..167
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 177..206
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 215..271
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 903 AA; 100014 MW; B8B3A879257D690A CRC64;
MAKVTVNGIE VEVDPSYTIL KAAEKAGISI PTFCYHPRMD PAGSCRICAV ELEDSKRVVM
SCVTPVSDGM KVLTESPKIH DARKTNLELL LLHHPLDCPV CDCGGECPLQ NMSFAYGATE
SRFESHRNDE PEDLKSDVLV FNANRCILCG KCVRICDEIQ DVHAIGFINR GFDTIIGPPL
GKKLDCEFCG DCLEVCPTGA ITDHFVRYKF RPWQLEQHQT TCTNCASGCQ MHVETENESI
VRVTSKEGLG PNEGSICVVG RFGFNHVQTP QRFDTPYMRV EHRLVPASWE ELLPELGNRL
NAIRRKGTDR IAGLISPRVS LEDAYAFQSF FRKVLRSNMI DTGARYGFMN AALPIVEATG
TLRPLVDHED LLKAKVILLI GTDPVAESNI TGLFLKRAAR KNRARLYVVD SEAITLSNRA
SDHIRVNPGG ESLFVSVLSE EIVSGGNLNS EWLTRKEELF KNWNVDPGAY QRLVHDLKTA
ETGILVTGRK IFRNEKANQS IKNMMKMIGA LGWIEREGCG ILPIPEAAND LGVLMMGATY
EWLPGLLDAR NESSRKKWES AWGTTLSYGS GGGLGQILQG IEEGKINALI TIGENPIGHF
PSGSKVRQIL GKLDLIVSLD MFQNELVDMA HFVLPASSSF ERVGHFVSVE GFVQKSVQTM
AHWGESLPDW EILEKISHAM GSPMGFDSSE NLMQEILRFL PDLSPSTRNG EHFVGKTGDI
HLVNPLAPSS LLPIPGEKIS ENASRTKIVE IPAHKANRSS VSRRYASWNE KDQPVLCEIG
QIPGEGEFIF SMTKSLFHSG KMTLQDPNLK KIQSEGKLRI NRQTARKRKI KKGEKITLSS
AYGRCSFTVE PSPMVSEFEL LFPEHFADSQ VLALFPPEIA LSPETGTPTI PRIRVSLSNE
TVV
//
