ID U4RJI8_HELPX Unreviewed; 733 AA.
AC U4RJI8;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093,
GN ECO:0000313|EMBL:EPZ98320.1};
GN ORFNames=N204_00260 {ECO:0000313|EMBL:EPZ98320.1};
OS Helicobacter pylori UM085.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1352344 {ECO:0000313|EMBL:EPZ98320.1, ECO:0000313|Proteomes:UP000016853};
RN [1] {ECO:0000313|EMBL:EPZ98320.1, ECO:0000313|Proteomes:UP000016853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UM085 {ECO:0000313|EMBL:EPZ98320.1,
RC ECO:0000313|Proteomes:UP000016853};
RX PubMed=24051312;
RA Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA Loke M.F., Vadivelu J.;
RT "Multiple genome sequences of Helicobacter pylori strains of diverse
RT disease and antibiotic resistance backgrounds from malaysia.";
RL Genome Announc. 1:E00687-E00713(2013).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPZ98320.1}.
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DR EMBL; AUSP01000001; EPZ98320.1; -; Genomic_DNA.
DR RefSeq; WP_001262903.1; NZ_AUSP01000001.1.
DR AlphaFoldDB; U4RJI8; -.
DR PATRIC; fig|1352344.3.peg.55; -.
DR Proteomes; UP000016853; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:EPZ98320.1};
KW Cilium {ECO:0000313|EMBL:EPZ98320.1};
KW Flagellum {ECO:0000313|EMBL:EPZ98320.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 26..44
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 50..69
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 127..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 246..272
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 293..311
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT REGION 360..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 80926 MW; 728B87FC1860F6A1 CRC64;
MANERSKLAF KKTFPVFKRF LQSKDLALVV FVIAILAIII VPLPPFVLDF LLTISIALSV
LIILIGLYID KPTDFSAFPT LLLIVTLYRL ALNVATTRMI LTQGYKGPSA VSDIITAFGE
FSVSGNYVIG AIIFSILVLV NLLVVTNGST RVTEVRARFA LDAMPGKQMA IDADLNSGLI
DDKEAKKRRA ALSQEADFYG AMDGASKFVK GDAIASIIIT LINIIGGFLV GVFQRDMSLS
FSASTFTILT IGDGLVGQIP ALIIATATGI VATRTTQNEE EDFASKLITQ LTNKSKTLVI
VGAILLLFAT IPGLPTFSLA FVGTLFLFIA WLISREGKDG LLTKLENYLS QKFGLDLSEK
PHSSKIKPHT QTTRAKTQEE LKREEEQAID EVLKIEFLEL ALGYQLISLA DMKQGGDLLE
RIRGIRKKIA SDYGFLMPQI RIRDNLQLPP THYEIKLKGI VIGEGMVMPD KFLAMNTGFV
NKEIEGIPTK EPAFGMDALW IETKNKEEAI IQGYTIIDPS TVIATHTSEL VKKYAEDFIT
KDEVKSLLER LAKDYPTIVE ESKKIPTGAI RSVLQALLHE KVPIKDMLTI LETITDIAPL
VQNDVNILTE QVRARLSRVI TNAFKSEDGR LKFLTFSTDS EQFLLNKLRE NGTSKSLLLN
VGELQKLIEV VSEEAMKVLQ KGIAPVILIV EPNLRKALSN QMEQARIDVI VLSHAELDPN
SNFEALGTIH INF
//
