ID   U4TWI2_DENPD            Unreviewed;      1248 AA.
AC   U4TWI2;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=HOOK N-terminal domain-containing protein {ECO:0000259|Pfam:PF19047};
GN   ORFNames=D910_03339 {ECO:0000313|EMBL:ERL85924.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL85924.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL85924.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
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DR   EMBL; KB631762; ERL85924.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4TWI2; -.
DR   STRING; 77166.U4TWI2; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR   CDD; cd22223; HkD_HkRP; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR043936; HOOK_N.
DR   PANTHER; PTHR18947:SF28; GIRDIN, ISOFORM A; 1.
DR   PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR   Pfam; PF19047; HOOK_N; 1.
DR   SUPFAM; SSF116907; Hook domain; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT   DOMAIN          16..157
FT                   /note="HOOK N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19047"
FT   REGION          1093..1183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1199..1238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          225..400
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          434..654
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          753..794
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          833..944
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1019..1053
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1113..1141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1142..1160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1161..1181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1199..1225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1248 AA;  142439 MW;  CC55400542F8AE91 CRC64;
     MAASRSDIEE FLSGPLVKWL STCVKKPETL QVYETFFDGA AINEVLLQID PEPSLPVPSP
     ANLQGFHITA ARIKIFHCII RNIKSIYEDE LRQVIVSLPD CVTLGRTPAS EQALTHLKLL
     VLLLLGCAVQ GPTKETFIAR IKELDVDVQH DIVACIKQIT DGQNLVLTTN WTEQAPQQLY
     THVKALTAER DKLLQQWVID LGQENISGVE SGRSSQEGVE SSHWAVELAD WKARLRKQRQ
     ELEEKTEILA EYKEELEHAT NLVTKLKAEN SELLTEARKA KAYRDEADAM RERAERADRF
     ELEIQRYRER LSDSEFYKVR VDELREDNRV LLETREMLEE QLVRARQRGD QVLELEAELL
     AAKQRINEAI LERDIAREKI QELADENLQL QQVAKSALQE TSLGNISMDS DMEESNSGDN
     SLSEQLTSNA QARALKLELE NKRLLSKLDS LKEDSFHETA DRILELEKEK KKLLLKCEQF
     QENCDRLTQQ NVELENLFKN AIQENRKVQN SMDSLKIVSD RQYQEIQNEK TKIADLERNI
     DSLSKEKQRV QTLCDVVKKR ADDAEKCLNQ TSEQLQALQK EVEKGEEAEK LGHELQDKVT
     SLEKENANLL KEVAKLREVI ETKEVTLDKN VEEKQKYERE IKKLNADTTN LVVQIEKLQE
     FERKSTELIS KASVYAETIA DLQKDLISEK VGNEKFKTSL DKLGLNLDIL DNDVNIIVEK
     ILQNANLIEI VSTQFSQAEE VAKSISKEWS EQCDKLYADI AALQAANDVL QNENATLKVD
     ISTLKSEVHS LQAQQTALQL ANSQLVAEKD DLSKQHSQQN RDREKILLDQ VTMRTLHEQL
     ANEYEELKLE QENLRKVNRD LRSEIRGLKE QNDCLEVKVS NAELEKENLR ADTINLNNLR
     AEHSNLEDDF RFLFTASERL NTKYKNVQDE LKALKMESRN LRLSQTEIQG ELNSRSDVVA
     GLHLENAKLR QQCDILLEMN QSLGSDRRSL MDHVSQLLAQ YHSLLTHSLE DQQQFHLEEK
     QYTEKVNNLC RQKEKLEEKI MEHYRKLDNA SAKKKGFGAT FVKRVRKAGS DIISKSRNHR
     SWHEDATRLT QSQYTLAGHG SGESDNRDSD NSTEEMSTSN QRNSSKTLEP FRRNTTGTGS
     LRDYKPRDDS ARDLSMHRSS IAEDDTGSVT PASQTNDANH AANPPLLVYN RISTVIGDPN
     QVQVSGSPST QGNAPPTTAA EENNSNAPAD KKEKNSKETA VWYEYGCV
//