ID   U4TZR3_DENPD            Unreviewed;      1069 AA.
AC   U4TZR3;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=D910_04509 {ECO:0000313|EMBL:ERL87109.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL87109.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL87109.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
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DR   EMBL; KB631904; ERL87109.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4TZR3; -.
DR   STRING; 77166.U4TZR3; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR   GO; GO:0048699; P:generation of neurons; IEA:UniProt.
DR   CDD; cd01259; PH_APBB1IP; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR039664; GRB/APBB1IP.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039665; PH_APBB1IP.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR   PANTHER; PTHR11243:SF23; LD06925P; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT   DOMAIN          231..342
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          42..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          649..883
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..955
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1037..1069
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..587
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..629
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        649..665
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        698..712
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..883
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        937..955
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1069 AA;  117803 MW;  BDDCE2BCD7D666C9 CRC64;
     MFVFTPRYSS WCIQRYLVAS PVLFPLLLSY FPLPDVQKLS LHESRTHSRS SSEASRGLSD
     DSILGGKNES GRTESPDNDS AFSDTVSMLS SESSASSGGS GAKPQTLNLQ NIHQDDASRI
     KAEKIRMAME KIKEANIQKL FVKVFTTDGC AKSLLVDEKM LCSYLLVDNL LLWTRESKNK
     IYFVERHDKI KLFVQPEQFL LSKDLKDSSD YDEHSRNMLL EDFFASTNGS LPEVEGPLYL
     KADSKKGWKK YHFVLRASGL YYFPKEKIKS AKDLVCLATF DNNQVYYGVG WKKKFKAPTD
     CCFAIKHPRL QEPKSTKFIK YLCAEDQATL EKWIIGMRIA KFGKQLMYNY RALMDELAQE
     EMDILANARS CSVQSIAVQS IQSNSTTPTQ GYSGSEAGYG TASGSEIYSA TSEAKADTAE
     PAVPVRAAAC PMEPLPVAKM PSTLNFQWVS AKRMEESARF SSAGRSLHFE ALFLNCIQRN
     HYDDNDVIGT IKRKPSMKPN LPLTNMTRQL KEVGETRDEV DGTLPISPVS YTNTGTLTRR
     HSRRKSNNSN DDSSNTGTLK RQHSYKSRGS LDSMGTRSGN STPLCGTPVR ERVSPFGDRS
     SPFGDRPPSA SSLRSPATSP TSPELSSMVS TLPAKASLVT RLFQTDSIIS LPPPPDSNGD
     TINEPLNYQL PPPPPEVYNS NLSLDSLPPP PNLSDLPPMS GSELTGSQLS LMSLPPPPGE
     DTGTMRRRAG GSASSSASAT PTNVLSPERT PIQGMSPDQT PTHSRLNTPC VSPPNSNCST
     PTQTSPPNAF SPTHRNGGAF PQGSPIYGQN HDRNLPAYGT ATNGFHQAPP YVNPPQYRQS
     STLPGGSAFS NNSGLRSSMR QVSLPRQISS NSISSSNSSG SSGNTIYGSV YEVRNSPKAP
     KKVAFQEPTS PKKGSKKISF NLTPQEVPPL PKKPNPPKRS ESTKLSSPKK LVEPPKEFLK
     DLQRVMRKKW QVAQKCKLEP ETTPHEVLGF RDPPTLLPDY KEHNVSNWVK EHYGPNNLYE
     NVYRDSPDGV VEYVSSPVHL RGDIRNSKRP PPPPPKRSET THLSTPKMH
//