ID U4U158_DENPD Unreviewed; 790 AA.
AC U4U158;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Suppressor of cytokine signaling 7 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=D910_03442 {ECO:0000313|EMBL:ERL86028.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL86028.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL86028.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
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DR EMBL; KB631777; ERL86028.1; -; Genomic_DNA.
DR AlphaFoldDB; U4U158; -.
DR STRING; 77166.U4U158; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE-SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 591..685
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 692..742
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 134..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ERL86028.1"
SQ SEQUENCE 790 AA; 88925 MW; DCA0A434D325582E CRC64;
ACNETFDIAS GCGNGGTVDS DCEERSLSQD ESFDGMSDVM CGEHFNTLKK GPHWTEVKQN
VSPIEPPPEF QDRPKALSPQ LVDFFCDRLT HQILKRVMLD FREECFGHFR LVAAAKPRRS
INCSLACRSY SSNSLQQQEH PISPPPLPSR AMNHKQPLIR PLPELPAGFT RAIPAISKST
TYLSYSSPHR SHSMSYQQSY PSPTSNFASS ASNFASSASP YVGHTPRPSS RSSLGGSSRL
SSSHNSLSVS HARRVDDSSF ITQAVSHDTL SSNQISDLYN VPFDSDMYAV PVDMVKEPGV
KPKRSGPYAC LGGNLILGHR RRGRTSTGLG LRDEGKPSGS DCRASQLKMG RKSAARSEQP
HWTFKPETKR HSVAGTSTGE PIHMTLQEVR TYLQALYSSS SDSSEVKEVS CRKKYCTNGI
FVSTNINNNN NSNKYQSRSI GHNQIITRPK KSTFLINIKN KKVKDSCDNS KTLTISPVKK
ESKKRKIFSF KQALCNIFRF RKFLSVEEKV SYPPENSRPK RFFNLYYVQD KTDSDKMQYD
LGANNGEELK TSLGGRALPP LPKKVEEGDE ETDKQALDFA TSIQKVKDYG WYWGPLSSEA
AEKILSNEPD GSFIVRDSSD DHYIFSLTFK LNNSVRHVRI EHFQGNFSFG SCTKFKSQTI
VEFIENAVEH SRSGRYLFFL HRRPVIGPVR VQLLHPFSRF KQVQSLQHIC RFIIHKNVRR
DLIPDLPLPR RMIDYLNTPH YYSERFVDLP DMPEDAELSS EENTLHCSFV PPAPSNVSSH
PIGINALEDF
//
