ID   U4U9P8_DENPD            Unreviewed;      1039 AA.
AC   U4U9P8;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Galactose mutarotase {ECO:0000256|ARBA:ARBA00021023};
DE   AltName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00032729};
GN   ORFNames=D910_04066 {ECO:0000313|EMBL:ERL86660.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL86660.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL86660.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose = beta-D-galactose; Xref=Rhea:RHEA:28675,
CC         ChEBI:CHEBI:27667, ChEBI:CHEBI:28061; EC=5.1.3.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00001712};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28677;
CC         Evidence={ECO:0000256|ARBA:ARBA00001712};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000256|ARBA:ARBA00004947}.
CC   -!- SIMILARITY: Belongs to the aldose epimerase family.
CC       {ECO:0000256|ARBA:ARBA00006206}.
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DR   EMBL; KB631843; ERL86660.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4U9P8; -.
DR   STRING; 77166.U4U9P8; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09019; galactose_mutarotase_like; 3.
DR   Gene3D; 2.70.98.10; -; 4.
DR   InterPro; IPR018052; Ald1_epimerase_CS.
DR   InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR047215; Galactose_mutarotase-like.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR   PANTHER; PTHR10091:SF0; GALACTOSE MUTAROTASE; 1.
DR   Pfam; PF01263; Aldose_epim; 4.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 3.
DR   PROSITE; PS00545; ALDOSE_1_EPIMERASE; 3.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742}.
SQ   SEQUENCE   1039 AA;  114300 MW;  02D140D0BA336494 CRC64;
     MAKYAQKEGV ELDEDEFDTY TEPSTGQLLS VRRFTWRTTS GVSVQVITYG ATITSIKMPD
     RNGTIDDIVM GFDDMKGYLQ PLNPYFGATV GRVANRIGSA TITIDDQTYH LTPNLAPHML
     HGGAKGFDKV NWSHHVNGTD VVLSCLSRDL EEGFPGDVIT TVTYRLTNEN RLEVELRSTS
     TRPTFVNLTN HSYFNLAGHA TGSSALYQHL LAINADQTTD VDKDSIPTGK LLPVAGTVFD
     LRIPHPLGAV IDKVPHYEGF DHNFCITKGT GQGGAFVARA EHPGTGRALE VYSNQPGVQF
     YTSNHIQSGT LSGKGGASYG KHGAFCLETQ NYPDAVNHAN FPPAVLYPGQ LYLHLVEYRL
     FCEMSCPRPV PLTVDAFGSL PDQSGAAREV KRFTWTNSKR TTVQVINWGA TITSIQLLDN
     AGHLEDVVTG FDHLEQYLGP DNRFFGATVG RVANRIAAGK FGLAGREYSL AKNNNGVNHL
     HGGVKGFDKV LWNYHVKGSQ LVLTYLSPDL EEGYPGDVLV TVTFELTEAN ELRIDYRAAA
     SKPTPINLTN HSYFNLAARR LGDVINRVPN AKGFDFNYCI SNPPGQMGLV MRAVHPPSGR
     GLELHCDQPG VQFYTGNALP EGDEIRGKSG AIYRKHGAFC IETQKYPDAV NQNNKHRAVS
     TGKRQRAVHS GKMLKSCEKS AVELKTSAFG SYRDPSGVCQ QVHKFTWTNP NKQTTVEVIN
     WGATITSIQL PDKTGKIEDI VTGFDSIEEY LGEKNRYYGA TIGRVANRIA RASMTVDGAR
     YQLAANNGPN HLHGGELGFD KVLWDHRTDG TRLILTYNSP HLDQGYPGAV LATVTFQLTD
     DNDFAIDYKA VTTRSTPVNL TNHSYFNLAG HGAGWAGLKE HEIVINADRY TPVDPAGIPT
     GRILDVSGSV FDLRVRRRLA DVLHKVPGAP GFDHNFCIQK PSVQDLAFVA EVQHRDSGRS
     MALYSNQPGV QFYTGNFMPE DDSSRGKLGE TYRKHGALCL ETQNYPDAIN QQADFPAVVL
     RPGEQYHHVA IFKFRLLDV
//