ID U4UFH3_DENPD Unreviewed; 3324 AA.
AC U4UFH3;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0000259|PROSITE:PS50188};
GN ORFNames=D910_06049 {ECO:0000313|EMBL:ERL88665.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL88665.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL88665.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR EMBL; KB632090; ERL88665.1; -; Genomic_DNA.
DR STRING; 77166.U4UFH3; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR Gene3D; 1.10.490.160; -; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF8; RYANODINE RECEPTOR 44F-LIKE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 2.
DR Pfam; PF00622; SPRY; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 2731..2764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2934..2952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3007..3026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3151..3172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3195..3217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3271..3289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..81
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 657..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1877..1902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2144..2168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2817..2860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2966..2988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2145..2160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2827..2843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3324 AA; 379069 MW; 5A3A1B02F72C6B1C CRC64;
MVRADELYNQ VTQDASGKGA SQGMSIGCFL DAATGYISFT CDGKPTSHKF KMEPETKLFP
AIFVEATSKE IMQIELGRTS TSLPLSAAVL QNSAKHVIPQ FPPRLKVQCL KPHQWARVPN
QNLQVHALKL SDIRGWSMLC EDPISMLALH IPEEDRCIDI LELIEMDKLL SFHAHTLTLY
SALCYQSNYK AAHVLCNHVD QKQLLYAIKS EYMSGPLRQG FYDLLISLHL EATATTMEVC
KNEYVIPIGQ ELKDLYENVD MGHSLRRLKM ESVVPQMKTS DISDLIDSIK NLYSPFFPLD
VVRDYVMTAL AESVEVNQLH NRDPIGGSNE NLFLPLLKLV DRLLLVGMLS DDNVDKLLIM
ICPETWNPTF KKEGKDEHRK GLLQMKMAEG AKLQMCYLLQ HLCDIQLRHR VESIIAFSHD
FVGDLQTDQL RRYIEIKQSD LPSAVAAKKT KEFRCPPREQ MNAILYFKNI EEEEKENCPL
GDDLCERMNN FHNSLMTHVS LQALQAPVEE DNPDEHEKRE PEKKTPEEVF RKVLISTIVR
WAEEAQIEMP NLVQEMFSLL VRQYDSVGEL IRALEKTYII NSKTKLDVAE MWIGLSQIRA
LLPVQMSQEE EEFMRERLWK LVNNHTFFQH PDLIRVLRIH ENVMAVMINT LGRRSQAQSD
ASTQAANPEG EIGGTKEKDT SHEMVVACCR FLCYFCRTGR QNQKAMFEHF DFLLDNSNIL
LSRPSLRGST PLDVAYSSLM ENTELALALR EHYLEKIAIY LSRCGLQSNT ELVEKGYPDL
GWDPVEGERY LDFLRFCVWV NGESVEENAN LVIRLLIRRP ECLGPALRGE GEGLLKAIVD
ANKMSDRISD RRKMMEESPE GTVNLQQFSH PLPESDEDED YIDTGAAILN FYCTLVDLLG
RCAPDSAVIS LGKNESLRAR AILRSLVPLE DLQGVLSLKF TLHNPAQGEE RPKSDMPSGL
TPPHKQSVVL FLERVYGIET QELFYRLLED AFLPDLRCAT MLDRHDGSES DMALSMNRYI
GNSILPLLIQ HSKFYSEAEN YATILDATLH TVYRLSKNRM LTKGQREAVS DFLVALTSQL
QPSMLLKLLR KLTVDVSNLS EYTTVALRLL TLHYDRCAKY YGSSGGQGVY GAASDEEKRL
TMMLFSNIFD SLSKMDYDPE LFGKALPCLT AFGCALPPDY SLSKNYDDEW YSNKSASGPD
GPYNPQPINT SSVQLNNDLN NIVQQFSEHY HDAWGSRKLE NGWRHGETYS GWDGNKTHPR
LKPYSTLSDY ERERYKEPVR ESLKALLALG WSVEHTEVDM PSNSRSSQFV RGETSNAFDY
NPHPVDMTNL TLSREMQNMG ERLAENAHDI WARKKREELI TCGGGIHPQL VPYDLLTDKE
KKKDRERSQE FLKYLQYQGY KLHRPNRGGQ QETEQATAGP SIELRFAYSL LEKLIQYLDK
ATINMKLLKP SQTFSRRNSY IKSSRDIKFF SKVVLPLMEK YFSTHRNYFI AVATATNLTG
AASLKEKEMV AALFCKLASL LRSKLAAFGA DVRITVRCLQ VLVKGIDAKS LVKNCPEFIR
TSMLTFFNNT ADDLGHTITN LQEGKYSHLR GTHLKTSTSL FYVNSVILPV LTSMFDHLAN
CEYGSDLLLD EIQVASYKIL QGLYHLGTDL TLHHERKYLK NEMEKYKPAL GSCLGAFSST
FPVAFLEPHM NKNNQSHVSM VTSDHMNQLL KNVLKLIKKN IGNENAPWMT RIATYTQQII
INSSEELLKD PFLPLAERVK RRTDAMFHKE ESLRGFIKSS TEDTSQIETQ IQEDWHLLVR
DIYSFYPLLI KYVDLQRNYW LRHNVEEAEH LYNHVAEIFN IWSNSQYFLR EEQNFISANE
IDNMVLIMPT ATRRTVVTDG SQPSVGKVKK KKKNRDKKRD KDKEIQASLM VACLKRLLPV
GLNLFAGREQ ELVQHCKDRF LKKMPEYEIV DFAKIQLTLP DKIDPADEMS WQHYLYSKLG
KKSVTVNTLD TNGKNQLEET VERIVAMSKV LYGLHMIDHP QQQQKGVYRS IVSTQRKRAV
LSCFRQASLH SLPRHRAINI FIRTYRDFWL QDENVGQEVM IEDLTQSFED SELKKKEGEE
EEGKPDPLTQ LVTTFCRGAM TERSGALQED PLYMSYAEII AKSCGEEEEE GEEGGEEGGE
GEEGGSSIHE QEMEKQKLLF NQARLANRGV AEMVLLHISA CKGVPSDMVM KTLELGISIL
RGGNFDIQMG MLNHLKDKKD VGFFTSIAGL MNSCGVLDLD AFERNTKAEG LGVGSEGAAG
EKNMHDAEFT CALFRFIQLT CEGHNLEWQN YLRTQAGNTT TVNVVICTVD YLLRLQESIM
DFYWHYSSKE LIDPAGKANF FKAIGVASQV FNTLTEVIQG PCTLNQQALA HSRLWDAVGG
FMFLFSHMQD KLSKHSSQVD LLKELLNLQK DMITMMLSML EGNVVNGTIG KQMVDTLVES
ASNVELILKY FDMFLKLKDL TSSTSFLEID INSDGWVYPK DFKEKMEQQK SYTPEEIEFL
LACCEVNHDG KLDYVGFIDR FHEPAKEIGF NLAVLLTNLS EHMPNEPRLA RFLETAGSVL
NYFEPFLGRI EILGGSKRIE RVYFEIKESN IEQWEKPQIK ESKRAFFYSI VTEGGDKEKL
EAFINFCEDA IFEMQHASAL MAVEESGGGG PTRATTYSYM TDEEEQRGGK DPIRRSYQAF
KDGIYYGFSA LSPSNIKHRL NEMQQMTIPE LFIALWLLAG FFKLIFYTFY YSGFGMAVVI
KYFLGILMSL MRGPVVEEPI VEIKEEEKVS HLRVLPPLPH AEDPNTQLQP FGMEVSKEEA
GQFKTPGHEG SATTQQSSGE EGEATTEEGT EQAESEVPEQ PLSLSDLLGG EQAKIAAQEK
AEAQAAQQAV MQAIESESKA KNIREPSAMQ QINFSAYAHR AVSFLARNFY NLKYVALVLA
FCINFMLLFY KVTTLGGDSD GSGSGKGADL LQGSAEGSGS GSEEEDDPPE LVIVDEDFYY
MAHVMRLAAM LHSIASLAML IAYYHLKVPL AIFKREKEIA RRLEFEGLFI AEQPEDDDLK
SHWDKLVISA KSFPVNYWDK FVKKKVRQKY SETYDFDSIS NLLGMEKTSF QQQESDEGNK
SIFWYIINID WRYQVWKSGV TFTDNSFLYS LWYFVFSILG NFNNFFFAAH LLDVAVGFKT
LRTILQSVTH NGKQLVLTVM LLTIIVYIYT VIAFNFFRKF YVQEEDEQVD RKCHDMLTCF
VFHLYKGVRA GGGIGDEIDP PDGDDYEAYR IMFDITFFFF VIVILLAIIQ EYTWNIHVMY
MHLSWDIHEL HYEHSMHVPG ICQS
//
