ID   U4UGM7_DENPD            Unreviewed;      1332 AA.
AC   U4UGM7;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=CLIP domain-containing serine protease {ECO:0008006|Google:ProtNLM};
GN   ORFNames=D910_10435 {ECO:0000313|EMBL:ERL93134.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL93134.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL93134.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC       {ECO:0000256|ARBA:ARBA00024195}.
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DR   EMBL; KB632345; ERL93134.1; -; Genomic_DNA.
DR   STRING; 77166.U4UGM7; -.
DR   MEROPS; S01.507; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 3.
DR   Gene3D; 3.30.1640.30; -; 2.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 6.
DR   InterPro; IPR022700; CLIP.
DR   InterPro; IPR038565; CLIP_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24256:SF527; CLIP DOMAIN-CONTAINING SERINE PROTEASE-RELATED; 1.
DR   PANTHER; PTHR24256; TRYPTASE-RELATED; 1.
DR   Pfam; PF12032; CLIP; 2.
DR   Pfam; PF00089; Trypsin; 4.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00680; CLIP; 2.
DR   SMART; SM00020; Tryp_SPc; 4.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 4.
DR   PROSITE; PS51888; CLIP; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 4.
DR   PROSITE; PS00134; TRYPSIN_HIS; 2.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW   Serine protease {ECO:0000256|RuleBase:RU363034}.
FT   DOMAIN          196..465
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   DOMAIN          547..751
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   DOMAIN          795..995
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   DOMAIN          950..1002
FT                   /note="Clip"
FT                   /evidence="ECO:0000259|PROSITE:PS51888"
FT   DOMAIN          1069..1331
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   1332 AA;  147070 MW;  9A5BEF111B478D24 CRC64;
     MEVNIEWFDK KLKVPQKMLS KSGTAKCEWF LLIFGAVLSI GYGLPQNKCS GVCAGLGDDS
     SETIDEGSDS DYGSLNDYSD DFVNATNGGI KINQESLRFL TPCQTPNFEV SLCTEISKCL
     VLDLVKSKKK YSQFVEASKC GPTNEDPTDF KVCCGRYNSF RNVSIAAGSQ SVKALPDISI
     LPKKCGTQKQ LIRGRIVGGK EAALGEYPWM ARLIHKNSHS QKSYGCAGFL IHPKYVVTAA
     HCINSEFSEI RGDPYSVLLG EHNVTTTVDC SPGGTFCADP FQVSRINKII IHENYDRHSK
     GHHNDIALIH LNKAIKLSKN TLELIDKGNE LPALYISDFV QPICLLSEEN PETKKYFLSG
     WGKTEEEETS TVKMKLDLTP YDKADCKEKF NIVELEIQDS QICAGGEKMK DACNGDSGGP
     LMLLNGTQHY AAGLVSYGIG CGMPGWPGVY TSIPFYLDWI LKQMLEVNTK SVKLGKTGKK
     NKRKKVQPVE DKTTTCGFNS AGTPYVCCGS GFNKVEQSDG DFSNPDYTTN PAIPDRSQCG
     WQSQNRIYNG EKTGLDEFPW MALIQYLTAA GKQKTACAGS LINRRYILTA AHCVTGAVLE
     KVGQPINVRL GEYDTSSPNI DCYHEGSFRF CNQPEVNVNI ETLIPHPGYN NADQNRRHDI
     ALIRLSQDVQ FSDYIQPVCL PLPSEASSNG ETLIVAGWGR TEFGKDSDVK LKLQVPKVNP
     NSCSSTFGAL GVSITENQIC AGGEDGKDSC KDAVLVQTDF RMFAVDQNLN NQATKITLSY
     PIALFQVEMN VDGRINIRLG EYDLSSPGQD CFVDAGFRIC NEPEVNVGID EIIPHPAYAG
     KPNRENDIAL IRLDKDISYS DFIQPICLPE PNEKSRNGER LTVAGWGRTE HGRNSNLKLK
     LAVPVSDFSN CSQIFSKEGI NLIEIHQICA GGEEGKDSCT DSIKLPQPNN CQTPNGGSGL
     CVSIFNCSRL LSIPQRNKDA RKIKFLRESI CGNQNTTVFV CCGSDDNFRS DTEDSENLGR
     NFDDLSRECG IETEIVDTSG KFGQIGNESE YQETGIGSSN LNITLKNRIF GGDDTEIIDF
     PWLALLEYHS ENNEEKLFLC GGSLISSRYV LTAAHCIPSG RTELVGVRLG EWNYANQEEN
     CGPTSKGMRC FDRAINVGIE SIHPHPGHTR DQKYHDIALI RLNEDVKITN HIKPICLPNT
     DDYLISGERL TISGWGLQHF DKRSSIKQKL NIPIVGLSKC SVMFDKFRDV SRTYQLGRGQ
     FCAGGERGKD SCTGDSGIPL MKRFDATSPG SRPRWRVEGI VSFGLGCGQR DYYGVYTKVS
     NYLGWIHRTI VP
//