ID U4UJK6_DENPD Unreviewed; 1735 AA.
AC U4UJK6;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN ORFNames=D910_11560 {ECO:0000313|EMBL:ERL94279.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL94279.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL94279.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; KB632384; ERL94279.1; -; Genomic_DNA.
DR STRING; 77166.U4UJK6; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 868..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1005
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1057..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1089..1107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1119..1136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1185..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1282..1303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1438..1472
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 593..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1637..1661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..631
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 170
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 512
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 951
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1735 AA; 197826 MW; E66DE79FCBDD4B75 CRC64;
MKIIAYGFLM HPGAYLRNGW NLLDFTIVVI GMISTALSFL TRDSFDVKAL RAFRVLRPLR
LVSGVPSLQV VLNSILRAMV PLLHIALLVL FVIIIYAIIG LELFSGQMHK TCFNDDTGEL
MEEAHPCGDG FNCSADYTCR PDWEGPNSGI TNFDNFGLAM LTVFQCITLE GWTDVLYNTI
NVLHQINDEM LQIQDALGRE WQWSYFVSMV ILGAFFVMNL ILGVLSGEFS KEREKAKARG
DFHKLREKQQ LEEDLRGYLD WITQAEDIEP EGEDQQNQDQ RNNTANEMAS TDQLGEEEIQ
QESWFSKKKK GFDRVNRRMR RSCRKAVKSQ IFYWLIIVLV FLNTGVLATE HYEQPPWLDD
FQEYTNMFFI ALFTLEMLLK MYSLGFQGYF VSLFNRFDCF VVIGSITEMV LTHSHVMPPL
GISVLRCVRL LRVFKVTKYW RSLSNLVASL LNSIQSIASL LLLLFLFIVI FALLGMQVFG
GRFNRKTEEK PRYNFDSFWQ SLLTVFQILT GEDWNVVMYD GIEAYGGLVF IISFSLSAAT
VSFLLIAFLK CFAFIGIDGH IFLIPTSDIL LNVFLAIAVD NLADAESLTA IEKEEEEKEQ
EGKRSKSPTP NQDEEVEEEE EDEDRSLEDE MEDGQYSERS GHDEEETESQ TKIAIEEGEE
GEQNEDNGDE EGSKVGARPR RISEIKQNSQ KVPIPPASSF FVFSPTNRFR VLCHWLCNHS
YFSNIILVCI LILTMFDYIF TGIFSVELFL KTISYGCILH KGAFFRSAFN VLDLVVVCVS
LVSIFNSQGA MSVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVIVAIKTIG NILMVTSLLQ
FMFAVIGVQL FKYVVKCVIV AIKTIGNIML VTYLLQFMFA VIGVQLFKGK FSHCTDGSKL
TAAECNGTYL IYVDGDINKP VMKDREWEPN RFHFDNVAKA MLTLFTVSTF EGWPGLLYVS
IDSNDENKGP IHNYRPIVAA YYIIYIIIIA FFMVNIFVGF VIVTFQNEGE QEYKNCELDK
NQRNCIEFAL KAKPVRRYIP KHRIQYKVWW FVTSKPFEYA IFTLIIINTI TLAMKFHGQP
DEYGNVLDYL NMIFTAVFAM EFVFKLAAFR AKNYFGDAWN GFDFIIVLGS FIDIVYQDVS
PPGQKKIKFS GNFFRLFRVM RLIKLLSRGE GIRTLLWTFF KSFQALPYVA LLIVMLFFIY
AVIGMQMFGK IESDDLESGS SLTRNNNFAS FFQAVLVLFR SATGEAWQEI MMDCADTKQA
RCDRRLNRTE SQFCGSDTAY PYFISFYVLC SFLIINLFVA VIMDNFDYLT RDWSILGPHH
LDEFIRLWSE YDPDAKGRIK HLDVVTLLRK ISPPLGFGKL CPHRVACKRL VSMNMPLNSD
GTVLFNATLF AVVRTSLRIK TEGNIDDANS ELRAVIKKIW KRTSPKLLDQ VVPPPGVDDE
VTVGKFYATF LIQDYFRRFK KRKEQELKEG DKEQLNTVTL QAGLRTLHEA GPELKRAISG
NLDELIDDNP EPMHRRNHSL FGSVWSSMKR GHSFNRAKSL KLNSTQIKIT PASSIDYLPY
NSIKNAVTEG MNHITSMTKN VVDNRASAIS LNDGYHDEEI PLRTLTNLHN GETERTYTVI
DSECVKRTFA LCSLQGDSQE LMPPTPPPRR VSPPGALHQQ SPNGGFTRIA SGLKLAQAQA
MAVAGFLPAP PDWPCEHGSG SDLLPQQHLD FVPRTEERHA RCCLLNHRAS FHGRG
//
