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Database: UniProt
Entry: U4UK89_DENPD
LinkDB: U4UK89_DENPD
Original site: U4UK89_DENPD 
ID   U4UK89_DENPD            Unreviewed;      1810 AA.
AC   U4UK89;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   10-MAY-2017, entry version 29.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=D910_10826 {ECO:0000313|EMBL:ERL93537.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL93537.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL93537.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M.,
RA   Henderson H., Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A.,
RA   W Huber D.P., Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae
RT   Hopkins, a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB632363; ERL93537.1; -; Genomic_DNA.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028820; Na_channel_60E.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF257; PTHR10037:SF257; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030742};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     22     43       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     55     78       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    113    132       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    610    641       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    699    724       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1055   1076       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1082   1100       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1160   1186       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1274   1295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1307   1326       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1364   1397       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1464   1487       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    232       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      501    731       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1021   1100       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1109   1195       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1247   1497       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1503   1564       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1810 AA;  206976 MW;  6459DBE834E044A3 CRC64;
     MATILLNCVF LAMTETIDEA EYIFLAIYTL EMIIKTIAKG FILNKYTYLR NPWNWLDFVV
     ITSGYATIGV EGANLAGLRT FRVLRALKTI SILPGLKTII NALLHSFKQL AEVMTLTIFC
     LMVFALFALQ VYKGELRNKC VLKMDDNNAT YEDWFNWTRN SENWLRRNET EEPILCGNVT
     GSRHCPITHT CLCVGENPNH GYTSFDNFLW SMLTTFQLIT LDYWENVYNM ERKKELVDHR
     EDSTFSFDPT NLNVKRLSRQ KIKKIDARKG VLLSSYTRKK TRRRKRNRNS TNPKSETGSG
     ILETSGGQPE NNESTSTKPS PKKNGRQSQT SGSPRPQQLA LPYPTQKHVQ LSDPKYPDTL
     HPNKPLGPTK SGMQSRQASS NSEGGKQSSL DDSGVGDDHE EGDATSEDVA SHTHSSLRRL
     EVTPVTVAVS PKQIKVIKCN GIGSNKKKSE LFALQTDYLS QIVVPDQEIP DRNCFCCERC
     CVDYEGWLQF QQGLYQIVKD PLFELAITVC IVLNTMFLAM EHHGMSESLL RALDIGNKVF
     TSIFTFECCL KIMALSKDFF NCGWNVFDLI IVSASLLDLI FELVDGLSVI RGLRLLRVLK
     LAQSWITMKV LLSIIISSIG ALGNLTFVLV IVIYIFAVIG MQLFSKDYTE EKFYPDPVPR
     WNFTDFFHSF MMIFRILCGE WIEPLWDCMR AEDYDGPGIC LAVFLPTLVM GNFMVLNLFL
     ALLLNSFNSE ELRHRKEEVG DVSKLTQSFQ RIRDLVRKRR LQEQRQNENN SRLEQIVREV
     MQRHADEEAF KAGKFSLGKI VFALDCFFAS AEFKKAQQFP RDKRSYQEAM NRPISIISYD
     IPEYQDILLE KGKDSSYSQQ HYALFLSTSS KDTDSPPKYS KSERRKLRNM SSGVDTTNSS
     RDTENTNLDA KSDKVLTTTE SKEDDGKTKQ AAADNLQPWQ TLVSYVDELT LGGRRNSKGH
     FIDGMGNFPG FGKPKPPKVP SNCFPATFYN RCSWLNRCSE SEVGIKWTKF RTAVLAIVDT
     STFEWFILVL IFASSVTLCF EDIHLDENPR LKELLYWTNL AFSIIFVIEM FFKWVALGFN
     KYFSSFWTLL DFLIVFVVQT KWDCADLNYT WENSKISFDH VGVAYLALFQ VATFEGWMEV
     MADAVDARKV NEQPTREANI YAYLYFVVFI VCGSFFTLNL FIGVIIDNFN MLKKKYEGGV
     LEMFLTESQK HYYTAMKKLG RKKPQKVIKR PMNAFLAMFY DLSNSRRFEI AIFVLIFLNM
     LTMGIEHYGQ PHAVFFILEV SNAFFTTVFG LEAIVKMIGL RYHYFTVPWN VFDFLLVLAS
     ILGILMEDIM IDFPVSPTLL RVVRVFRIGR ILRLIKAAKG IRKLLFALVV SLPALFNIGA
     LLALITFIYA IIGMFLFGHV RQQGALDDMV NFETFGRSMH LLFRLITSAG WNDVLESLMI
     EYPDCDPHYR NQTNGNCGYP LLSIIYFTSF IIINYMIVIN MYIAIILENF NQAHQEEEIG
     IVEDDLEMFY IRWSKYDPHA TQFIRFAQLS DFIASLDPPL GIAKPNTVAL VSFNLPICRG
     NKIHCLDILH SLVKHVLGHV EETDNFRQLQ EQMNIKFKKQ FPTRKELEIV SSTRIWKRQD
     KAARLMQRTW KEYLRRKKEK EREAEEVDET TQTSSPGDWR SRLSTFLHVH RGSRASSRKS
     SRASDASDLS ELGGPWLNLP LLLLSSAANV PPEDLDLRRE SADVVSIKVS QATPEGGSPP
     RASTPAGQYS SPLNPYFNQH SFRMSIKLPG LGSVSSGGVA WLPLSLLYCI QKIREKDWGV
     ALPLNNLPVF
//
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