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Database: UniProt
Entry: U4UZH5_9RHOB
LinkDB: U4UZH5_9RHOB
Original site: U4UZH5_9RHOB 
ID   U4UZH5_9RHOB            Unreviewed;       451 AA.
AC   U4UZH5;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-SEP-2017, entry version 30.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HIMB11_00109 {ECO:0000313|EMBL:ERL99169.1};
OS   Rhodobacteraceae bacterium HIMB11.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae.
OX   NCBI_TaxID=1366046 {ECO:0000313|EMBL:ERL99169.1, ECO:0000313|Proteomes:UP000016848};
RN   [1] {ECO:0000313|EMBL:ERL99169.1, ECO:0000313|Proteomes:UP000016848}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HIMB11 {ECO:0000313|EMBL:ERL99169.1,
RC   ECO:0000313|Proteomes:UP000016848};
RA   Durham B.P., DeLong E.F., Rappe M.S.;
RT   "Draft genome sequence of marine alphaproteobacterial strain HIMB11,
RT   the first cultivated representative of a unique lineage within the
RT   Roseobacter clade possessing a remarkably small genome.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERL99169.1}.
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DR   EMBL; AVDB01000001; ERL99169.1; -; Genomic_DNA.
DR   RefSeq; WP_022571224.1; NZ_AVDB01000001.1.
DR   EnsemblBacteria; ERL99169; ERL99169; HIMB11_00109.
DR   PATRIC; fig|1366046.3.peg.117; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000016848; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016848};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016848}.
FT   DOMAIN      143    273       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      359    428       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     151    158       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   451 AA;  51426 MW;  DC2BD6769F9010C5 CRC64;
     MAQEIWGEIK ETIKQTVGAN NFNTWIAPLN FCEIENGVAV FEVPTNFIGN YVAQNFSDVL
     LFQLSTLFGD VRRLRFDVAT SVQSAQPKAR KVVENVEHEA KSSDELPGAP LDPRFKFDTF
     VVGKPNELAH AAARRVGEGE AVSFNPLFLY GGVGLGKTHL MHAIAWELQS RRPDLNVVYL
     SAEQFMYRFV QALRERKMMD FKQLFRSVDV LMVDDVQFIA GKDSTQEEFF HTFNALVDQN
     KQIIISADRA PGEIKDLEER IKSRLQCGLV VDLHPTDYEL RLGILQSKVE QYSTQYPDVT
     FDKNVLEFLA LRISTNVRVL EGALTRLFAF ASLVGRHITL EVTQDCLADI LRASERKITV
     EEIQRKVSEH YNIRLSDMIG PKRLRTYARP RQIAMYLAKQ MTSRSLPEIG RRFGGRDHTT
     VMHGVKRVEE LKVQDGQIAE DLEMLRRALE A
//
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