ID   U5E9P2_NOCAS            Unreviewed;       671 AA.
AC   U5E9P2;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   Name=acs {ECO:0000313|EMBL:GAD83173.1};
GN   ORFNames=NCAST_18_00250 {ECO:0000313|EMBL:GAD83173.1};
OS   Nocardia asteroides NBRC 15531.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1110697 {ECO:0000313|EMBL:GAD83173.1, ECO:0000313|Proteomes:UP000017048};
RN   [1] {ECO:0000313|EMBL:GAD83173.1, ECO:0000313|Proteomes:UP000017048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 15531 {ECO:0000313|EMBL:GAD83173.1,
RC   ECO:0000313|Proteomes:UP000017048};
RX   PubMed=24884595; DOI=10.1186/1471-2164-15-323;
RA   Komaki H., Ichikawa N., Hosoyama A., Takahashi-Nakaguchi A., Matsuzawa T.,
RA   Suzuki K., Fujita N., Gonoi T.;
RT   "Genome based analysis of type-I polyketide synthase and nonribosomal
RT   peptide synthetase gene clusters in seven strains of five representative
RT   Nocardia species.";
RL   BMC Genomics 15:323-323(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD83173.1}.
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DR   EMBL; BAFO02000018; GAD83173.1; -; Genomic_DNA.
DR   AlphaFoldDB; U5E9P2; -.
DR   STRING; 1824.SAMN05444423_11725; -.
DR   eggNOG; COG0365; Bacteria.
DR   Proteomes; UP000017048; Unassembled WGS sequence.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:GAD83173.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017048}.
FT   DOMAIN          56..108
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          115..505
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          560..638
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   671 AA;  73357 MW;  0F15E3ECA42C2725 CRC64;
     MPCPCRWSQP PARVSPLFVR RRFLVTGAVT DPTRPDHATS YPPAAEFVAQ ANADASLYAR
     GDTDRDGFWA EQADRLHWHT PFTQVLDWSD APVARWFADG ELNVAYNCVD RHVLDGHGDQ
     VAIHWEGEPG DSRAITYREL LDEVSRAANA FTALGLVAGD RVAIYMPMVP EAIVSMLACA
     RLGLPHSVVF AGFSPTALRQ RVDDAQARLI VTTDGQWRRG KPAPLKSAVD EALGDDPTSV
     EHVLVVRRTG LDVPWTEVRD LWWDETVSLA SPSHEAQPFP AEHPLFILYT SGTTGKPKGI
     LHTTGGYLTQ TAYTHHNVFD HKAGTDIYWC TADIGWVTGH SYIVYGPLAN RATQIVYEGT
     PNSPTEHRHF EIIEKYGVTI YYTAPTLIRT FMKWGREIPD AHNLTTLRLL GSVGEPINPE
     AWRWYREVIG ANKTPIVDTW WQTETGAIMI SPLPGVTDTK PGAATAALPG ISAAVVDDDG
     TPLGNDASGL LVLDQPWPSM LRGIWGDMDR FRETYWQRFA SEGWYFAGDG AKADADGDLW
     ILGRVDDVMN VSGHRISTAE VESALVGHPA VAEAAVVGAS DATTGQGIVA FVILTGSAAT
     GDELVTELKA AVSLEISPIA RPREIHIVPE LPKTRSGKIM RRLLRDVAEG RELGDTSTLV
     DPTVFEAIAK G
//