ID   U5EU92_9DIPT            Unreviewed;       327 AA.
AC   U5EU92;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Integral membrane protein 2 {ECO:0000256|RuleBase:RU367061};
OS   Corethrella appendiculata.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Chaoboridae;
OC   Corethrella.
OX   NCBI_TaxID=1370023 {ECO:0000313|EMBL:JAB55883.1};
RN   [1] {ECO:0000313|EMBL:JAB55883.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Salivary glands {ECO:0000313|EMBL:JAB55883.1};
RA   Ribeiro J.M.C., Chagas A.C., Pham V.M., Lounibos L.P., Calvo E.;
RT   "An insight into the sialome of the frog biting fly, Corethrella
RT   appendiculata.";
RL   Insect Biochem. Mol. Biol. 44:23-32(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367061}; Single-
CC       pass type II membrane protein {ECO:0000256|RuleBase:RU367061}.
CC   -!- SIMILARITY: Belongs to the ITM2 family. {ECO:0000256|ARBA:ARBA00006794,
CC       ECO:0000256|RuleBase:RU367061}.
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DR   EMBL; GANO01003988; JAB55883.1; -; mRNA.
DR   AlphaFoldDB; U5EU92; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   InterPro; IPR040145; ITM2.
DR   PANTHER; PTHR10962:SF1; INTEGRAL MEMBRANE PROTEIN 2; 1.
DR   PANTHER; PTHR10962; INTEGRAL TRANSMEMBRANE PROTEIN 2; 1.
DR   Pfam; PF04089; BRICHOS; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|RuleBase:RU367061};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367061};
KW   Signal-anchor {ECO:0000256|RuleBase:RU367061};
KW   Transmembrane {ECO:0000256|RuleBase:RU367061};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU367061}.
FT   TRANSMEM        63..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367061"
FT   DOMAIN          199..294
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000259|PROSITE:PS50869"
FT   REGION          25..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  37633 MW;  460149105432099D CRC64;
     MTILTKAFGD VKKSDKIPVL PLINSEITPT APPEPATSSN AGDPESAHNN IVLVRRARRM
     SSALTLILFL IALLVTCLGV IGGILFYRQY AYERMQRMRF HCKIPYDSKN VNSNDVYFMN
     AFLRDNDLMQ TMLDRVNNVN DDLFKPINEF EKEISKDFLI NEKLALSQEK IDPTNFFKEE
     FELDLSDDEA YEKIDVPEFR DGRSGRFLHD FNKNQSVIID KDSKRCFVMP LDQENVLKPK
     SLADLITKMW NGYYTINTDV VRKNMRVVTP AVEDFSDISP IISNECSDMK TYKLEKYVSG
     VFKRSINKVN KFAVFVGNGI IEYDIHE
//