ID   U5EY30_9DIPT            Unreviewed;       847 AA.
AC   U5EY30;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Corethrella appendiculata.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Chaoboridae;
OC   Corethrella.
OX   NCBI_TaxID=1370023 {ECO:0000313|EMBL:JAB59242.1};
RN   [1] {ECO:0000313|EMBL:JAB59242.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Salivary glands {ECO:0000313|EMBL:JAB59242.1};
RA   Ribeiro J.M.C., Chagas A.C., Pham V.M., Lounibos L.P., Calvo E.;
RT   "An insight into the sialome of the frog biting fly, Corethrella
RT   appendiculata.";
RL   Insect Biochem. Mol. Biol. 44:23-32(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GANO01000629; JAB59242.1; -; mRNA.
DR   AlphaFoldDB; U5EY30; -.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        400..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        449..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        538..556
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        571..593
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        605..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        645..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        776..800
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          51..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   847 AA;  96914 MW;  E87233AF7A15F0A6 CRC64;
     MGSLFRSEEM TLCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDGIPML DTGESPEAPQ PREMIDLEAT FEKLENELRE VNQNAEALKR
     NFLELSELKH ILRKTQVFFD EQEGGLHTTE SMTRALITDE SRAGNKMGPV QLGFVAGVIL
     RERLPAFERM LWRACRGNVF LRQAMIESPL EDPSNGENVY KSVFIIFFQG DQLKTRVKKI
     CEGFRATLYP CPEAPTDRRE MAMGVMTRIE DLNTVLGQTQ DHRHRVLVAA AKNLKNWFIK
     VRKIKAIYHT LNLFNLDVTQ KCLIAECWVP VLDIETIQIA LRRGTERSGS SVPPILNRME
     TFEDPPTYNR TNKFTHGFQA LINAYGVATY REMNPAPYTI ITFPFLFAVM FGDLGHGTIM
     ALFGLWMVLK EKPLAAKKSD NEIWNIFFGG RYIIFLMGAF SMYTGFIYND IFSKSLNIFG
     SAWSVNYNAS TVMTNKALQL DPATDDYRQT PYPFGVDPVW QVAPLNKIIF QNAYKMKISI
     IFGVIHMIFG VCVGYFNHRY FKNKLAIVCE FIPQIIFLVF LFFYMTLLMF IKWSKFSASH
     EEARFRPGCA PSILITFINM VLFNYNVQVK DAHDCRWYMF SGQEFMQKFL VIIAVLCIPW
     MLLAKPIMIM RSRKEEAHQP IMHNENGDTE AGLTQNANQV AQSGGGAGQG GHGGHEQEEM
     SEIFIHQGIH TIEYVLGSVS HTASYLRLWA LSLAHAQLAD VLWNMVLKMG LRSDSWYGGI
     ALWAIFAFWA MLTVSILVLM EGLSAFLHTL RLHWVEFQSK FYGGLGYAFQ PFSFEVILES
     SGSSAEE
//