ID U5HEL2_USTV1 Unreviewed; 1910 AA.
AC U5HEL2;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=MVLG_05555 {ECO:0000313|EMBL:KDE03986.1};
OS Microbotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther
OS smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=683840 {ECO:0000313|EMBL:KDE03986.1};
RN [1] {ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p1A1 Lamole {ECO:0000313|Proteomes:UP000017200};
RA Cuomo C., Perlin M., Young S.K., Zeng Q., Gargeya S., Alvarado L.,
RA Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Mehta T.,
RA Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Microbotryum violaceum strain p1A1 Lamole.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KDE03986.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE03986.1};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Butler R., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA White J., Yandava C., Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KDE03986.1, ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE03986.1}, and p1A1 Lamole
RC {ECO:0000313|Proteomes:UP000017200};
RX PubMed=26076695; DOI=10.1186/s12864-015-1660-8;
RA Perlin M.H., Amselem J., Fontanillas E., Toh S.S., Chen Z., Goldberg J.,
RA Duplessis S., Henrissat B., Young S., Zeng Q., Aguileta G., Petit E.,
RA Badouin H., Andrews J., Razeeq D., Gabaldon T., Quesneville H., Giraud T.,
RA Hood M.E., Schultz D.J., Cuomo C.A.;
RT "Sex and parasites: genomic and transcriptomic analysis of Microbotryum
RT lychnidis-dioicae, the biotrophic and plant-castrating anther smut
RT fungus.";
RL BMC Genomics 16:461-461(2015).
RN [4] {ECO:0000313|EnsemblFungi:MVLG_05555T0}
RP IDENTIFICATION.
RG EnsemblFungi;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; AEIJ01000585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GL541719; KDE03986.1; -; Genomic_DNA.
DR STRING; 683840.U5HEL2; -.
DR EnsemblFungi; MVLG_05555T0; MVLG_05555T0; MVLG_05555.
DR HOGENOM; CLU_000893_0_1_1; -.
DR InParanoid; U5HEL2; -.
DR OMA; TIEVWQS; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000017200; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000017200};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1335..1521
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1630..1892
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1910 AA; 210911 MW; 175691A6710E12E4 CRC64;
MDYLDSNLHS AILSSLAANL ASSSTHDDVH LLTESFAGIQ PVTNGVIGGV LNRINGDSHT
ASGGAHTLIT LSQVDGIIAF CDYAAKAPAK SDNLNRLLVL LQGAPNWQLE AAVGVQVAQD
YAPGDRLAYS LVSAALIVAG ASPNERTAAL GVLSQFHKAL LAAIETSEGH RIIGYLLPAL
NGARRAVGNS PFPWTVHDEL PLTPEPSRDL VESVVAAIAY EWDPSTEGGR VALATLKQYD
SSMRGLSPGL IALVQIEFEL AYWTSAIVPA VKSGGGWRAL LEGDPASITA GGQAAYASAT
RAHGTFENTY TMLERMDGEY PPDPYAFDVL LSSLKLAVVA TIATGSPTQI LAKLFDDLLT
HPATVVDEPL QTGAVESLQV FARAFPSTLP TALNTIRNFI SSPSPVLEQS GVLAPSSTMI
AASACYASLI NLSTNPALRE SAIQSLLNHF VVPEREPLVR QGDVVANDAK SIRSLQEAMS
DPIKVSVSSN VVHAVARLAL TFKDEQITTL VTSILLQRLV GTSPVVDGAI LFELSELATI
VNADTFADIL AGISRVSKHA KQDEAMSQTL LNAQTRLAIA ASSRQKFHVK YLSETLALFV
EEGGAGDRKT TASERAAGLL NLVPILDAFL TGAKFDSRQD VDGSLVSLFR SAWYLIVLSG
FVSTPSRIAD WQRAALVRIA QRTPGLLRGI KDDFVATELD FNPILRNKEH VLSPDAARQE
LAAILPSAAS FARSLPAPQV VFLLTVVRLE SLRAEAGQPS IVLSYFHVQG INENPQLYAL
MTSIAEHVNN TFVSRLSQLV TGHTMDPAVY HEVREILLQC CHTLGKVRTT AIRYLNDLFT
SFPSLLCSGE VVSTMLELLT VTRRACLAEF VDEYTPLYRF HSSRANFDVV LPDDYSIRNS
VLTELHRYAR SWLKAGLTRA PSEMRGLLQD YIDGTEVAPP TTSLKAFADD EMGKSVAIDL
IRMPPSNARE ASLPAWGEWR ADNSSNFART FGAKSFFGGE ASRTADTSRD AILDELEALA
EQLDQHKMHV KLVDIRALLY RSGGHLVKAQ SPDPDILQQL VHLPARIFTD VVIEIATEVW
TWVVDARPEL EPRLMVEVAE AWQSTIQRRQ GLFSCEANRK NPLDVSTQFT PTDKDYMTKE
FIHATRLLQP HMTLLQFLSS RFQAFRYRDT DLVHACMRIL KRSTDAAKSW STHQLAREIR
MRMLSFGFCV LQGSELESAV EYNFRDSLYE AAMTWFELPP GWTYGSNRIQ LKADLQAMEE
LHSTIKSDKP AYDYILSASR SRKASGLPYN SSAATAGSLQ TRRQQLLLAL LENEMDRLKL
WTNPLLDPKR GAIPTPRSTA SDANWVRMAN IAWSHWPGVA VQLPERTKLP AVAAEVTRLV
RSNPLRAQHI PDALQYFVGD KISPESERHL RVLLFWAPVS VISALRFLFP LFEGDPILLQ
YALRVLEHHP VEITFFYIPQ VVQALRFDEL GYAERFIFET SKISQLFCHQ IIWNMKANAY
RGDDGDVEDP MKPTLDRMVD MIVSSLSGDA KDFFQREFAF FNEVTSISAK LKPFIKSSKH
EKKAKIDEEM AKIKVDVGVY LPSNPDGIVV DVDRKSGRPL QSHAKAPFMA TFKVRRDHKR
SVTADLDAQD ALIEDGESSG QVQPKSFDTW QSAIFKVGDD CRQDVLALQI IAMHKNIFTA
LGLDLLVTPY RVTATGPGCG VIDVIPNATS RDEMGRAKVN DLKSFFVLKY GSPDGIEFQR
ARNNFIQSMA AYSLLCYIVQ IKDRHNGNIM IDGKGCITHI DFGFLFDIGP GGVKFEPSSF
KLSHEMMVLM GGKDSVGFRH FSELTVKSFL ACRPYAQQIV DTARLMLAAE FPSFKGEPTM
QRLTERFRLE LREDEAAEYM KGVIANAHEN PRSIVYDIFQ EKTNGIPYVR
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