ID U5HHW8_USTV1 Unreviewed; 1871 AA.
AC U5HHW8;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Actin cytoskeleton-regulatory complex protein PAN1 {ECO:0000256|ARBA:ARBA00015110};
DE AltName: Full=Actin cytoskeleton-regulatory complex protein pan1 {ECO:0000256|ARBA:ARBA00020728};
GN ORFNames=MVLG_06638 {ECO:0000313|EMBL:KDE02848.1};
OS Microbotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther
OS smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=683840 {ECO:0000313|EMBL:KDE02848.1};
RN [1] {ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p1A1 Lamole {ECO:0000313|Proteomes:UP000017200};
RA Cuomo C., Perlin M., Young S.K., Zeng Q., Gargeya S., Alvarado L.,
RA Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Mehta T.,
RA Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Microbotryum violaceum strain p1A1 Lamole.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KDE02848.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE02848.1};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Butler R., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA White J., Yandava C., Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KDE02848.1, ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p1A1 Lamole {ECO:0000313|Proteomes:UP000017200}, and P1A1
RC Lamole {ECO:0000313|EMBL:KDE02848.1};
RX PubMed=26076695; DOI=10.1186/s12864-015-1660-8;
RA Perlin M.H., Amselem J., Fontanillas E., Toh S.S., Chen Z., Goldberg J.,
RA Duplessis S., Henrissat B., Young S., Zeng Q., Aguileta G., Petit E.,
RA Badouin H., Andrews J., Razeeq D., Gabaldon T., Quesneville H., Giraud T.,
RA Hood M.E., Schultz D.J., Cuomo C.A.;
RT "Sex and parasites: genomic and transcriptomic analysis of Microbotryum
RT lychnidis-dioicae, the biotrophic and plant-castrating anther smut
RT fungus.";
RL BMC Genomics 16:461-461(2015).
RN [4] {ECO:0000313|EnsemblFungi:MVLG_06638T0}
RP IDENTIFICATION.
RG EnsemblFungi;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AEIJ01000828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GL541777; KDE02848.1; -; Genomic_DNA.
DR STRING; 683840.U5HHW8; -.
DR EnsemblFungi; MVLG_06638T0; MVLG_06638T0; MVLG_06638.
DR HOGENOM; CLU_235129_0_0_1; -.
DR InParanoid; U5HHW8; -.
DR OMA; DATVYKY; -.
DR OrthoDB; 2734911at2759; -.
DR Proteomes; UP000017200; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00052; EH; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00027; EH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000017200};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 193..282
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 226..261
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1007..1024
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1207..1266
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1550..1728
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1762..1859
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1414..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 627..670
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 698..750
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..575
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..776
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..882
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..991
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1871 AA; 204519 MW; 3CAEE0BE4D4E5DEF CRC64;
MSWLNQPYAG GYPGQQPQPG YLQSQPTGYM GQPMQQQPLQ GQRTGYAPQG GFQPTGFIGQ
RPPMQQMQVQ PTGYAPSMLQ PQPTGYPAPM QQRPMATGYP FQQQQPPPPQ QQQPLMSQPT
GMPGMGGGMQ SQFLSTFMPA PSLQPTSFID PSQMQFAHSG HNGASLAQTF QQRNQAQTGH
ADVPIPWALT KDEKKRYDQI FRAWDQQGTG FIEGRVSKEV FGQAGLDQND LMSIWNLADV
QDRGKLNIDE FHVAMGLIYR RLNGNPIPQT LPPEMAPPSA RDLDDSVGFL TNLLKNDNNQ
RSTNQDFDGG RGSMAKARSL HDTAPRRDRK DATVFRNDDD EARTVYKSSA RHLNQDQIRS
RSETDSASSD LDDIRNRLRT TRSTLDRSRD QDDEDEDLKD QLRNMKRRIQ RVQDDIDHNL
GSGRRTTAKE DERRKLEREL LRLEYEELPE LERRIKEKER DKKRDQRKYA LERDSRNNDS
DRYGDRDQYS TRKDPYESRS SSRRESPERG YNRGTYDNED GREKRSRDRD DDHYTSPSRG
ITSPSRARTE PPPPPPAPAS ERATPPPPPP APVAALKSPA VDTRSMTPTE RQAHIRAQAQ
ARIQERLRAL GVAAPASGEN AVDTSVADRL EKDKAEAAAK AAKADEDLKA KELERQAKLE
REKLRGIAIE QSINSQNEAA VEQVREEVNA AAPESMIAKA ANEQLDVEED ALARREAQLK
REKEERMARI KQLEQEAHEA EENYARSKAM FAPKIAKVAP PPPAPRARPA APPFRTAPAP
ASATKPAVDD DETAPPAPRA ADPAPAVISS FLSPPVARSD VGAVGASPSS ESKNPFYRLQ
QGGASPAATS AAPAASPSGK PNPFFASSSP PAGPPAPSAP LLAPVSPAQT ALRQPGLVVK
PEYRSPPVDD DDWDAKEKDV DESDSDDEIG GLRAAQANLA AKLFQGLGLG PARPASAQGN
TPTRSTAASP DLGAPAAPPA PPAPSAPAAS PTPKAAPAFV VPTEAPPRSA LLGAIQGGLT
LRKTETKDKS GPAVTGSVID DPSPPVRTHR APSPSSAFAG PAAQVAPAAN GGGSFGESHY
NANRQSIAWL GSMAAVEGSS QNAQTFSNIA TVAEDEEPAE EAKSSTFPAI VAASNEDDPL
APFDMTTTHR MKSLFAFQGE GPNDLSFKEN LVLNVHPSKD PAGDWLYGTV ESSGEQGWVP
KSYVEAFTPQ SAKALYAYDA ASEEEMSFLE KDIISIVDSA DASWWQAENN GLIKLVPASY
IELGTSEAHL ASALASPRLE TAMTRPHDKD QRLPMPSENS RIFKVSGSRV ADDSDSEIET
PDGGDPKERE AERLRVLEAA GLLVRGGPSA DRRKRRQAPA RPPTKPTTGS VSGGGEGNEI
LAEESVNADS APEEDVDQEG RVKDAYDIYQ RVMRELPPVP TTTSNRLSMV SDSTTPSTTT
GSMLYPTSPP ASPAPSSSTV ASSLATGASI KDQWQATTSG LRAKLSRPRG SSSAALDHAR
LHISGPIIGE ATGSAQSKSQ ESATPSNFGA TWASMIDSGA LEIMPDRERK RQESMFELIT
TEQAYVQSLQ LTIEVFFNRL QPVIPAKALQ VIFANIEDIL LFDTIFLSEL EDRQRTARLY
IDTIGDIVKK HVRGYECYRG YCVNQANAAR TLADLKRSDP QLRSFLEGSR IKGLELEHFL
LEPMQRVTRL PLLLRQILRY TEQDHSDRAL LTQSLEIAEG ILGVINEAVR AHENEERLVY
LSDVIEFSHS IEARLDLTAP TRLMGLRRLL KEDRVTKARS GRKLNVYLFN DLLIFTETKA
GGNEVVYRWP IALEECIIRD QSRDDLTFAV AHRGDTINVR TSSARQCLLW TQEIEQARKA
CLAAVQKRRG M
//
