ID U5IJ65_9NIDO Unreviewed; 6705 AA.
AC U5IJ65;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087};
DE AltName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00029611};
GN Name=pol1ab {ECO:0000313|EMBL:AGB05580.1};
OS Porcine torovirus.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Tornidovirineae; Tobaniviridae; Torovirinae; Torovirus;
OC Renitovirus.
OX NCBI_TaxID=237020 {ECO:0000313|EMBL:AGB05580.1, ECO:0000313|Proteomes:UP000111898};
RN [1] {ECO:0000313|EMBL:AGB05580.1, ECO:0000313|Proteomes:UP000111898}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH1 {ECO:0000313|EMBL:AGB05580.1};
RX PubMed=24122107; DOI=10.1007/s00705-013-1861-x;
RA Sun H., Lan D., Lu L., Chen M., Wang C., Hua X.;
RT "Molecular characterization and phylogenetic analysis of the genome of
RT porcine torovirus.";
RL Arch. Virol. 159:773-778(2014).
CC -!- FUNCTION: The 3C-like serine proteinase is responsible for the majority
CC of cleavages. {ECO:0000256|ARBA:ARBA00003512}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JQ860350; AGB05580.1; -; Genomic_RNA.
DR RefSeq; YP_008798230.1; NC_022787.1.
DR MEROPS; S65.001; -.
DR GeneID; 17603141; -.
DR KEGG; vg:17603141; -.
DR Proteomes; UP000111898; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd20762; capping_2-OMTase_Nidovirales; 1.
DR CDD; cd21557; Macro_X_Nsp3-like; 1.
DR CDD; cd21162; NendoU_tv_PToV-like; 1.
DR CDD; cd21413; unc_tv_SF1_Hel-like; 1.
DR Gene3D; 3.90.1140.10; Cyclic phosphodiesterase; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR009097; Cyclic_Pdiesterase.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR037227; EndoU-like.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR044371; Macro_X_NSP3-like.
DR InterPro; IPR043609; NendoU_nidovirus.
DR InterPro; IPR044397; NendoU_PToV-like.
DR InterPro; IPR044863; NIRAN.
DR InterPro; IPR046438; NIV_2_O_MTASE.
DR InterPro; IPR046436; NIV_EXON.
DR InterPro; IPR039573; NS2A-like.
DR InterPro; IPR027352; NSP13_ZBD_CoV-like.
DR InterPro; IPR009461; NSP16_CoV-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR044355; SF1_Hel_unc_tv.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF05213; Corona_NS2A; 1.
DR Pfam; PF06460; CoV_Methyltr_2; 1.
DR Pfam; PF19215; CoV_NSP15_C; 1.
DR Pfam; PF01661; Macro; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR SMART; SM00506; A1pp; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF142877; EndoU-like; 1.
DR SUPFAM; SSF55144; LigT-like; 1.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51653; CV_ZBD; 1.
DR PROSITE; PS51154; MACRO; 1.
DR PROSITE; PS51958; NENDOU; 1.
DR PROSITE; PS51947; NIRAN; 1.
DR PROSITE; PS51955; NIV_2_O_MTASE; 1.
DR PROSITE; PS51953; NIV_EXON; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|PROSITE-
KW ProRule:PRU01303};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PROSITE-
KW ProRule:PRU01298}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PROSITE-
KW ProRule:PRU01298}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 2165..2198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2248..2267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2386..2412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2497..2516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2523..2544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2739..2762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2915..2938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2944..2966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2973..2993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2999..3019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3430..3450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3457..3478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3484..3507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3514..3538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3558..3583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1605..1786
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 4414..4645
FT /note="NiRAN"
FT /evidence="ECO:0000259|PROSITE:PS51947"
FT DOMAIN 4953..5104
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT DOMAIN 5259..5340
FT /note="CV ZBD"
FT /evidence="ECO:0000259|PROSITE:PS51653"
FT DOMAIN 5481..5820
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT DOMAIN 5818..6031
FT /note="ExoN"
FT /evidence="ECO:0000259|PROSITE:PS51953"
FT DOMAIN 6299..6439
FT /note="NendoU"
FT /evidence="ECO:0000259|PROSITE:PS51958"
FT DOMAIN 6441..6705
FT /note="Nidovirus-type SAM-dependent 2'-O-MTase"
FT /evidence="ECO:0000259|PROSITE:PS51955"
FT ACT_SITE 5832
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 5834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 5933
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 6009
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 6014
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298"
FT ACT_SITE 6335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
FT ACT_SITE 6352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
FT ACT_SITE 6384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
SQ SEQUENCE 6705 AA; 763304 MW; DC30B5D7C4FB971C CRC64;
MSKISKKPTS ETEPLLCSSI LDLTSRSQFL DQCLGTPQNL VSLSKMDPSI SVSPTLGLKS
TSTPYSSLQS LQLLVLNTSS TQFKWTTGSI SKLKAQLERE LCRGLVPLND ITPGSNYVEL
SLMIPSLLTG QEISTTTTSP EMYSDTVQNC IKLMETNLLK GVQALRDQTS CQEYFLNANY
QSLIPPQLLL NAMRMSSVAT LSPLTLESTR LLLKLSHFHG GTSVSYTSMI KGFADCSRRD
EKCLKRRLTK EQKSQEEGSF DAGRVITLGG RMYRYEVIVL KCSDENDDFT GYDDPIEQLE
YDLETVPHCW KELVEGKCLT RAKATWDLTE DLDVELDRIH IEEVKSLQRS GASWDLSSVG
VDSQDLEERV FSRVWLKQSS KYFGTKLQQV SELFKSEGLA ELVSTMNGIN SVRVGDKWLN
FRDQGKSCVF FVYTNDNVYL ATTRQRVSCD YIITKFKSVK WIGNKPDKCK ITKVLAWLIS
VNRVKNSTRV ITPMLCKQGK ISHKEVDYLD MSVLDKYASC AFGPTCVQKV KKFLLSYYKC
DSDFDLLDNF LTPVKCGKKK MVFEKCSCKN HQFYVAQFDN HVVLGLGRPN GILYPEEVPA
YARVYAVGFA NDKHGVEIHY YSEMDNNQLP QEYCFVAHDQ HHQQGGEGDY VNFHPDDFED
GPFPNLDFDI DYDDLIWPDA PIPVPSPYGY HQGQRLRDLC VADGGFGCDC PRCDGSYIYH
PVRPRHYESF EEVGPFFKMC EFRFTFSGQI YNQFYGLGPK VRLQDLVKAG NKLLQLLIRG
QLEELDLPSE ILNCLTYLKL GLNIHPFVWP APFFTSSGEW VDIFDGNDFA FGIDFNKTIG
MIESVQFLCE NFLSLSCPLE KLYQDLHTDE EVKQMFWSTT HMKYIYLALI HSERSFKAIL
NNTQLNNSQL AKLITIGTLD APIVSPCACE GNCDHAKPYN WTGILNKVSK YATLKQLIGL
SYHDKRLLVL KMTQRYFQIE EGLFQPVQLL MAPFYSFNDN VEPDEQPLTG MFHQNVMQMF
DTCVMPDVIT KLKRTRASAN DLFCILADYF RRSFAYRYYR VAEFSDLEKT QVFTDLTSAL
SGGTSKIGAY AVCRMVEPRS VATTCEKSMF PPEVVRAIRG YLPVSFNTGV MNYIDENCDF
DYCNLEFCIS GKGLTKLSQS GLIECKTNLF VVRFNTVPLL YVTSKPICLS EFSLEASVSL
LGDFNVNVDI VPGATLFGLY FTNGKACQDV WETLPRFGLG CLSTPKLHPK FKPFDNLAEV
CFFKQKVKLV SLVNNFTPVE IVKPEVPKTV IVDLLPYYGS VGFQGFVAPK CVLPGTLATH
YCKLNNQLDK CVQVTKLAVA HAFYFKPSNM GSLFHLDPMY GKSYGKPAVV QFEPVGLIKE
VNVLVYQFRE HVAIHYFPEC PTYVADGHYP SKFVGIWLGY LPSVEECKIA QHNRSVYVPA
CFRLSRTGGY HIQQNEDFER SSITVTYRYA KNFETKSLTP MFQMFSKIFG KSKQEIMCAL
NSLTPEASKV LTLFCNEFDP AYTVQTLSDE VAFETSASPE LVACALAYII GYELCLTVKT
GGSCESLDIG SSLEQVYIDY DTCENSWKLS TDLQDDDSED LDLPFDQYHE FKLGKASVVL
VKDDFKSVYD FLKNEQGIDY VVNPANSQLK HGGGIAKIIS CMCGPKLTNW SNGYIKQHKK
LDVTCAVRSP GFQLGKNVQV IHVVGPKNGD VDVQGKLNSS WRSVFQNIKA DSTVLTSMLS
TGIFGCSVVS SVSTLLDNLL FLEKDVVVFV VTNDLNQYKE ALSVIEGYQD FHGIPNFGNT
CWFNAIYQLL KSFATKEQLV QDLVNCFDDF YDCPTKQCVE WVCEQLGVKF GEQHDAVEML
CKIFDVFKCD VRVGYDCLSR LQHVQLGTCK NIPAEAVLMF SGQDKSGHWT AARKLNGEWF
VFDDKLVIKK DPDWSKVVLV LRDRGLYRAS DFETPRPRRR RVAHRVPRDT LSQDAIVFTE
EKRFASGTVL VDTCLESVES FDLEGSHVSF VESVDDCFSD CDQVSSVKSV QDDLEQSCDD
KTDIEDEKIV VVEDVSEDVT EESPLQQPTQ QQNVVNDVDF EQVQQQNELE VLPSIFISDF
KLSFEKRLEP IVKQDNFEDI ELQDMANIEQ SMPCKAMNWK DVFFQQYIGF KSDFVSLANV
SKFQVVLYAL SLWLFLVYCF ADFSLLGKFC LYVVLLWFSH VLVTARKVDL SVISLGSESY
VLRVLSSVKV PNFIVVNCDG IQWLILKLLY YSFYFYDFVV KVVVIIFQMP QLRCFTWPLL
RLGFVDTFLS HHILAFSNKQ VSQSCLPVYG DDRRYIYVPS WCKESFNTLL QRAKQLTAMG
YSKTLDNWYY QCCSKTTKPS SCFNVRDFVF DDDCSSHKQY GFLSSLFVYI VFYTGFVTFW
LPLLFFYCAL FMCTFKNLPV DTTKPIKWTV LQQVVDDLVS IITKPLFGRP ACPPLSAYLT
ATTAEEAVRS SRSLFGRFCT PVGFQQPIMN VVNGVSVSSL GFINPLMWPL FVVVLLDNRF
VWFFNVLSYI MLPIFVVVLF YFYLRKICGC VNIKGVTKNC TKHFQNFSKP LVAAGVHGNR
TNFTYQPMQE HWCDRHSWYC PKEEHYMTPE MAMYIKNYYN LATAPTADTT WCDYVKTTPT
MTWANFKFSL FKPNETVMCG PSSHADAMLL SWYAFLHGVR FTLNPSVIDI PTPVQPIYVS
SDSDDSLDRV CDVNLRPTKS KGKFKKQSIA YFSSGPVDLW YYVTLVISLG AIFVFMYSCL
MVGQYVVMPK DKFFGVNPTG YSYVNAQPYL HANPPVLRNS DGMVLATPLK VPSISYSVYR
LLSGHLYFTK LIVDENECTP PFGAARLSHE FTCNDFTYVL PAHLRVLNRY IMLIHPDQLH
MLPFEVEHST HTRLCYVTGT NVVECLPTFE IVSPYVFVVI VAIFTILFLF LLRMYIVMYS
YFKVFTYVVF KLLFVNTIMV LFVVCLPPLV PGVIFVLALW LCDSVVFLLY LAILSLFILP
WFYVMVFILM VGGFSFWWMM KSSDVVHLTP DGLAFNGTFE QISKCVFPLN PLIVNRLLLD
CQMSHADLVE KSKLKTTEGK LATEMMKVFM TGDTAYYQPS NFSFQSVFSK VTSPFTIHAK
PPMPMFRLYV HFNGQCVGTT CTGTGFAIDD VTIVTARHLF ERDDLKPTHL SVELAGKSFW
CTWKEPRVES WKFEGENAYI LVENLRDFYG QDFKYLPFSK IEDDFYKRME PATIYSIKYG
SEFATQAWQA VNGHFVCSNT EGGDSGAPLV WHDTIIGVHQ GICDSFKTTL VSDNSGKMMT
EVKGHHVDPP IYYKPVIISA AYNKFVADSD VNVGECTNYH NFGDDDFLPM HDELEKVSFG
DKMRRYCQGL PKYLEPLHYF HVPSFWQPFK KQSISTNVSW VVENLHFIFS LYFLVCDFVA
YWWLDDPFSV VLPLFFIVQL LSTVVLKNVL FWNTSYLVTL AVTFYVHSEV AESMYLLGFF
SDQIVNRIGL ILVVSVMCLF VVVRVVVNVK RAIFVVIVSI LLICVNVMVG VVQFSSFVTL
VMFDLYAVFT ALLTPQPVVA IMMLILFDTK CLMSFAFVVI VLSFRFFRDY RFVKVLHNFC
NFDFVLTQLS LFRYRHHNQG NNPSHYEALW LFLKEIYYGV QDVKYEVFSP QAGTYNVKFL
TDMTEQDQLE AVEQVQRRLQ RFSIVQDKHS QRLVLYSKNV EFLRAQIQQQ RALGANPFII
TTLTAKDIAI DNVEVHNPSQ FKPEDMQAHM WFYSKSPVFF GQVPMPTNVQ TAAVLDTTYN
CQDLTADEKN NVAATLQIQN AALTLSLFDE CRQFLENEIG DVPAIMWQSD DVADVKQLEA
QIEKLRVVLD GMRLGTSEYK ATRKQINILQ SQLDKALAFE RKLARFLEKV DQQQAITNET
QKQLSAFKNL VKQVYESYMA SLKVKIVESN DASCLLTSTE LPRKLVLMRP VTGIDDIKIV
EKANGCEITA FGTTYTTGPG SNLAGLAYSS TQPLSAYPFI FNLEGVFKQQ ANIGYKTVEC
NMSSTNGTVL YKGKIVAVPS DDEPDFIVCG KGYKLDCGVN VLLIPSIVRY ITINLTDQLQ
KQSLKPRRRL RYQGVRLGGV NLGEHQAFSN ELVSTVGFTT WVSSTICSDK SHKHPWFVQV
PINEKDPEWF IHNTLLKDNQ WVLDVKPTHW MVNADTDEQL FALSLSDDDY IKAESILSKW
SPITQDVECW FKDLKGYYIV SGLQPLWPVC PKKICNLKIV PIYQPQSVRY ADQPTHFFSM
PVVHKNFLNA FYELQEGFPG KKQVAPHVSL TMLSLTDEEV IKVENILDEL ELPTTYITIT
NPHMMGRHYV CEVEGLQSLH DEVVSVLRQH GIACDQSRLW KPHLTIGEVV DGSNFSDFGD
FAMTCKVEDL DFVKLGAPKA NARYEFIATL PVGDFKLLRD VWSACRHLCF QNGAYQSSRS
KHYIDLATEY NAGIVKVNKS NTHSVEFVGK RYMIKRVKDQ HEFALSRTSF LPSIIPHHMV
SYNNEWFLVR GPTTQWSLGD LVYAIWLGDQ DYLAECGFVF NPSRDEFFED AKQRSHLAFL
LEPAILSFCD IFSYIKKFGL PYKLTLDNMD LCGNLYDFGD YPCPNVVDNQ SALFVLAEVW
SMTRKPFPPK FAQVLACEMQ VPDDFQLHFQ NTLLSGKYFD KAMCLNNVRP FLQDPANLTT
TPFFSQHSGV WSHFYNPIYG LVEVDLDEFS NLPEVLQQLI TVQDPIANNM LPAISIGDGV
FSANVPPVLP AKQKVPLYDV GLCQDLTDAG IDCGEAFNYF YYLSNPAGAL ADVCYYDYQG
TGFYSPKLLA GVYDFMKRVT ECYQTNERFT YEQAKPRKSS MGVNISGYQQ DAVYRALGPE
NIMKLFEYAQ KAPLPFCTKI ITKFALSAKA RARTVSSCSF IASTIFRFAH KPVTSKMVEA
AQNSQGFCLI GVSKYGLKFS KFLKDKYGSI EQFDVFGSDY TKCDRTFPLS FRALTAALLY
ELGGWEEESW LYLNEVNSYM LDTMICDGML LNKPGGTSSG DATTAHSNTF YNYMVHYVVA
FKTILSDLTE SNRVMRVTAH NAYTTGNYDV FNTLLEEQFQ TNYFLNFLSD DSFIFSEPGA
LKIFTCENFS NKLQTILHTK VDQTKSWSAS GHIEEFCSAH IIKTDGEYHF LPSRGRLLAS
LLILDKLSDV DIYYMRFVAI LCEAAVYSRY QPEFFNGLFQ VFLDKVQQFR RDYCCDPCPP
QLLDRSFYEN LVFTSNTEVG VVDCYLENFK LQCEFEQQSS LDKVCFCCPN PAVSVCCECY
VPLPLCAYCY YVHVIISGHS KIEDKFRCPC GNDDIRDLFI VLNDSICIYQ CKNCVGSDRL
RLSLLSDSDQ IVRLPGFRAN SASIAKNGVA QLLTSVDNVD ISLDWNHQET VLQNVARIVY
HSANMTQMSI EVVYVNFNLI RNDGSSAVLD IPNFKCPDTS YCLFYKPGKT GSLKFTGKGT
LTSCYDNKNL TWFKATCPDF SQPWRQATCF VIQQHDAVYP PLKSTQYDNV TFVMGPPGTG
KTTFVYNNYL SKASPSNRFV YCAPTHRLVG DMDEKVDGAV VVSAYNDRTY RNPIWKKDDS
YDILLCTHNT LPFIKSAVLI VDEVSLIPPH VMVKILSMGF KKVVLLGDPF QLSPVYKNHK
VHFKYDTFYL LQLATQKRYL TACYRCPPQI LSAFSKPYCD VGVDLVSFNS KPGKFDIIVS
KQLANLQDFS VLSVLAKDYP GYTILVNYRA AVDYAMQNGL GDVTTIDSSQ GTTAANHLLV
LFGASNFSKT INRVIVGCSR STTHLVVVCC PELYKHFQPI FNWPEPVYRY FGMEKQSDFN
IIPEVSSLVF CDIEFWHYKA DPNLKTRTVY PGQIAVVTSQ TLQLYLGVFD DTGYKSALRG
LPKDVFVPPN WVWMRKHYPS YEQHAYNMQR LFKFIIDTTC GQPCFILYSC SNDLKSLKFY
VEFDTNYFCD CGDLAICLMR DGLYKCRNCF DNMLVSKLVN CKYLDVQKER VKLQDAHDAI
CQQFHGDSHE ALCDAVMTKC LYLTSYQAAF KDTLHVKYKD LCLEIQYKIT SPYVRYDGVN
KRYLYRDHGA MYYFRTPRSP MQNVYKYEVG AHAEYCINIC NSYEGCQSFG KTCTKCIHIH
CVVEQFLADD RFKDFILVSV VKSDYIEQSL SPAARALMLT VTRVEGKNFY TLNGQRYDLY
DYDLSQSVMR VVGASVKPLP LYSVVVGLGI NCTVGCVLPN VPMKLKDDLL VTDVPLSTVK
LDLPTWYYIT WPTLSNKTSR WKFAGAQVYD CSVHIYVEAT GEQPLYYLQL GNGDNLRELP
DTLFSTGRLY NLEHDPSLNF NVHQLPVETI PKNKHVFAGD FTEVGTDIGG VHHVVALNGY
KGTIIPNYVK PIGTGLINVG KAVKRTTLVD VCANQLYEKV KQQLVDVKVS KVIFVNIDFQ
EVQFMVFAKS DDDIQTFYPQ KDFIRSYYEW PQILPALESH YDLKNYGQDP LFMPQPVNFS
KYTQICTFIQ DHVKVARNSL IWHLGAAGVD GCSPGDIVLS SFFKDCLVYS WDIKDYDTLL
EKHSYDCKFR PNLIVSDIYN VSSNVTEVLE DCVNRLALGG TIVFKTTESS RPDIQLSEIS
KYFAGIQFFS TGVNTSSSEV FVVLKYKLFS EPLGEELCSP NILRRIAAYR NKLCIVPNFK
IFSTSLSYKF SGVKFVQKCF YCSVPRQFCA SGLVQEVPML CQMNH
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