ID U5J7V7_9ENTO Unreviewed; 139 AA.
AC U5J7V7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS Human rhinovirus sp.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus.
OX NCBI_TaxID=169066 {ECO:0000313|EMBL:AGH09855.1};
RN [1] {ECO:0000313|EMBL:AGH09855.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/Nicaragua/INI00015/2010 {ECO:0000313|EMBL:AGH09855.1};
RX PubMed=24119298;
RA Garcia J., Espejo V., Nelson M., Sovero M., Villaran M.V., Gomez J.,
RA Barrantes M., Sanchez F., Comach G., Arango A.E., Aguayo N.,
RA de Rivera I.L., Chicaiza W., Jimenez M., Aleman W., Rodriguez F.,
RA Gonzales M.S., Kochel T.J., Halsey E.S.;
RT "Human rhinoviruses and enteroviruses in influenza-like illness in Latin
RT America.";
RL Virol. J. 10:305-305(2013).
CC -!- FUNCTION: Component of immature procapsids, which is cleaved into
CC capsid proteins VP4 and VP2 after maturation (By similarity). Allows
CC the capsid to remain inactive before the maturation step.
CC {ECO:0000256|ARBA:ARBA00025202}.
CC -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; JX129399; AGH09855.1; -; Genomic_RNA.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.20; -; 1.
DR Gene3D; 4.10.80.10; Picornavirus coat protein VP4; 1.
DR InterPro; IPR003138; Pico_P1A.
DR InterPro; IPR036988; Pico_P1A_sf.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02226; Pico_P1A; 1.
DR Pfam; PF00073; Rhv; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 1.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Pore-mediated penetration of viral genome into host cell
KW {ECO:0000256|ARBA:ARBA00023255};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022561};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 93..138
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT NON_TER 139
FT /evidence="ECO:0000313|EMBL:AGH09855.1"
SQ SEQUENCE 139 AA; 14984 MW; 0E0AE06A34098455 CRC64;
MGAQVSRQNV GTHSTQNAVT GGSSLNYFNI NYFKDAASNG ASRLDFSQDP SKFTDPVKDV
LTKGIPTLQS PSVEACGYSD RIIQITRGNS TITSQDIANA VVAYGVWPQY LTDADANAID
KPSHPDTSSD RFYTLDSKL
//
